GWAS

(GWAS data used on the Zebrafish Mutation Project Web site comes from http://www.genome.gov/gwastudies/.)

Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits.

The human homologues of the following genes have been identified in this study:

Gene name Reported Gene Ensembl ID Alleles found Associated phenotype Study Count
abca1a ABCA1 ENSDARG00000074635 9 Not determined 13
ABCB11 ABCB11 ENSDARG00000070078 2 Not determined 6
abcb11a ABCB11 ENSDARG00000011573 4 Not determined 6
apoa1 APOA4 ENSDARG00000012076 1 Not determined 11
apoa1 APOA5 ENSDARG00000012076 1 Not determined 22
apoa1 APOA1 ENSDARG00000012076 1 Not determined 13
apoa4 APOA1 ENSDARG00000040298 1 Not determined 13
apoa4 APOA4 ENSDARG00000040298 1 Not determined 11
apoa4 APOA5 ENSDARG00000040298 1 Not determined 22
apoeb APOE ENSDARG00000040295 None Not determined 42
C12orf51 (3 of 3) C12orf51 ENSDARG00000090715 None Not determined 9
C12orf51 (1 of 3) C12orf51 ENSDARG00000079151 3 Not determined 9
celsr1a CELSR2 ENSDARG00000069185 3 Not determined 17
CELSR2 CELSR2 ENSDARG00000088231 3 Not determined 17
celsr2l CELSR2 ENSDARG00000019726 1 Not determined 17
cetp CETP ENSDARG00000030872 1 Not determined 27
gck GCK ENSDARG00000068006 1 Not determined 7
ggt1 GGT1 ENSDARG00000023526 None Not determined 4
hmgcra HMGCR ENSDARG00000052734 1 Not determined 9
hmgcrb HMGCR ENSDARG00000059301 1 Not determined 9
hnf1a HNF1A ENSDARG00000009470 None Not determined 21
ldlr LDLR ENSDARG00000029476 1 Not determined 15
LDLR (2 of 2) LDLR ENSDARG00000089730 None Not determined 15
LOC100148888 C22orf36 ENSDARG00000091128 1 Not determined 2
LOC100330423 C12orf51 ENSDARG00000003682 2 Not determined 9
LOC100331214 LPL ENSDARG00000034667 None Not determined 21
LOC100332488 TBL2 ENSDARG00000043357 None Not determined 4
LOC100333044 GCKR ENSDARG00000086620 None Not determined 39
LOC560512 PVRL2 ENSDARG00000077419 None Not determined 9
LOC560816 PVRL2 ENSDARG00000062831 1 Not determined 9
LOC569014 GGT1 ENSDARG00000018342 1 Not determined 4
LOC794105 GGT1 ENSDARG00000087063 None Not determined 4
lpl LPL ENSDARG00000087697 1 Not determined 21
LPL (1 of 2) LPL ENSDARG00000091659 None Not determined 21
MR1BB_DANRE MTNR1B ENSDARG00000086493 None Not determined 15
mtnr1ba MTNR1B ENSDARG00000053833 None Not determined 15
mtnr1bb MTNR1B ENSDARG00000086883 None Not determined 15
myl2 MYL2 ENSDARG00000053424 None Not determined 4
MYL2 (2 of 2) MYL2 ENSDARG00000043349 None Not determined 4
pvrl2l PVRL2 ENSDARG00000063390 1 Not determined 9
pvrl4 PVRL2 ENSDARG00000094356 None Not determined 9
rps11 RPS11 ENSDARG00000053058 None Not determined 2
si:ch1073-189o9.1 MLXIPL ENSDARG00000089107 None Not determined 13
si:ch211-141e20.2 PVRL2 ENSDARG00000093349 None Not determined 9
si:ch211-214p13.3 PVRL2 ENSDARG00000087403 1 Not determined 9
si:ch211-215c3.2 ZNF827 ENSDARG00000076171 6 Not determined 4
si:ch211-222f23.6 PVRL2 ENSDARG00000042880 None Not determined 9
si:ch211-286e11.2 C22orf36 ENSDARG00000074308 None Not determined 2
si:dkey-159a18.1 SORT1 ENSDARG00000056145 1 Not determined 13
si:dkey-159f12.2 RPS11 ENSDARG00000093606 None Not determined 2
si:dkey-222h21.12 GGT1 ENSDARG00000092350 None Not determined 4
si:dkey-222h21.13 GGT1 ENSDARG00000087054 1 Not determined 4
si:dkey-222h21.14 GGT1 ENSDARG00000075055 None Not determined 4
si:dkey-258f14.3 LDLR ENSDARG00000075974 None Not determined 15
si:dkey-281i8.1 PVRL2 ENSDARG00000069936 None Not determined 9
si:dkey-30k22.7 CELSR2 ENSDARG00000037286 3 Not determined 17
si:dkey-7f3.15 APOA1 ENSDARG00000094929 None Not determined 13
si:dkey-7f3.15 APOA4 ENSDARG00000094929 None Not determined 11
si:dkey-7f3.15 APOA5 ENSDARG00000094929 None Not determined 22
si:dkeyp-69c1.6 BUD13 ENSDARG00000006666 2 Not determined 8
six2a SIX2 ENSDARG00000058004 None Not determined 1
six2b SIX2 ENSDARG00000054878 1 Not determined 1
six3a SIX3 ENSDARG00000058008 None Not determined 2
six3b SIX3 ENSDARG00000054879 1 Not determined 2
six7 SIX3 ENSDARG00000070107 None Not determined 2
six9 SIX2 ENSDARG00000068407 None Not determined 1
six9 SIX3 ENSDARG00000068407 None Not determined 2
slc14a2 SLC14A2 ENSDARG00000051914 2 Not determined 4
sort1a SORT1 ENSDARG00000029402 None Not determined 13
sort1b SORT1 ENSDARG00000056252 7 Not determined 13
tbl2 TBL2 ENSDARG00000074603 None Not determined 4
tomm40 TOMM40 ENSDARG00000092112 1 Not determined 23
tomm40l TOMM40 ENSDARG00000036721 None Not determined 23
zgc:110064 APOE ENSDARG00000086370 None Not determined 42
zgc:112992 APOA1 ENSDARG00000086281 None Not determined 13
zgc:112992 APOA4 ENSDARG00000086281 None Not determined 11
zgc:112992 APOA5 ENSDARG00000086281 None Not determined 22
zgc:162040 RSPO3 ENSDARG00000070081 1 Not determined 7
zgc:171581 ABCA1 ENSDARG00000079009 5 Not determined 13
zgc:194131 APOA1 ENSDARG00000020866 2 Not determined 13
zgc:194131 APOA4 ENSDARG00000020866 2 Not determined 11
zgc:194131 APOA5 ENSDARG00000020866 2 Not determined 22
zgc:92195 PNPLA3 ENSDARG00000044086 1 Not determined 6
znf259 ZNF259 ENSDARG00000043542 1 Not determined 11

The following reported genes could not be linked automatically to a zebrafish gene:

  • ABO
  • APOC3
  • OAS3
  • PSRC1
* quick link - http://q.sanger.ac.uk/lj9c35eu