GWAS

(GWAS data used on the Zebrafish Mutation Project Web site comes from http://www.genome.gov/gwastudies/.)

Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility.

The human homologues of the following genes have been identified in this study:

Gene name Reported Gene Ensembl ID Alleles found Associated phenotype Study Count
antxr2a ANTXR2 ENSDARG00000060520 2 Not determined 2
antxr2b ANTXR2 ENSDARG00000063011 1 Not determined 2
card9 CARD9 ENSDARG00000067672 2 Not determined 9
il12ba IL12B ENSDARG00000033727 1 Not determined 14
LOC100001799 IL12B ENSDARG00000069504 None Not determined 14
LOC559568 TBKBP1 ENSDARG00000061473 2 Not determined 2
LOC570502 KIF21B ENSDARG00000009733 8 Not determined 5
ptger4a PTGER4 ENSDARG00000059236 1 Normal 12
ptger4b PTGER4 ENSDARG00000035415 1 Not determined 12
runx3 RUNX3 ENSDARG00000052826 None Not determined 3
si:ch211-213n8.3 IL12B ENSDARG00000054542 1 Not determined 14
si:ch211-234e14.2 PTGER4 ENSDARG00000079907 None Not determined 12
si:dkey-24n17.6 ERAP1 ENSDARG00000013024 1 Not determined 7
zgc:56194 ERAP1 ENSDARG00000021859 None Not determined 7

The following reported genes could not be linked automatically to a zebrafish gene:

  • HLA-B
  • IL23R
  • LTBR-TNFRSF1A
* quick link - http://q.sanger.ac.uk/8k1af7gd