GWAS

(GWAS data used on the Zebrafish Mutation Project Web site comes from http://www.genome.gov/gwastudies/.)

Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.

The human homologues of the following genes have been identified in this study:

Gene name Reported Gene Ensembl ID Alleles found Associated phenotype Study Count
arhgef7a ARHGEF7 ENSDARG00000006299 3 Not determined 3
arhgef7b ARHGEF7 ENSDARG00000073848 2 Not determined 3
arntl1a ARNTL ENSDARG00000006791 1 Not determined 3
arntl1b ARNTL ENSDARG00000035732 1 Normal 3
BEGAIN (2 of 2) BEGAIN ENSDARG00000089545 1 Not determined 1
bsx BSX ENSDARG00000068976 1 Not determined 1
ca10a CA10 ENSDARG00000052644 1 Not determined 2
ccdc85a CCDC85A ENSDARG00000039497 1 Normal 1
ccdc85al CCDC85A ENSDARG00000005343 1 Not determined 1
ece1 ECE2 ENSDARG00000087841 2 Not determined 2
eefsec EEFSEC ENSDARG00000004696 1 Not determined 1
etv5a ETV5 ENSDARG00000069763 2 Not determined 3
fto FTO ENSDARG00000044216 2 Not determined 32
gab2 GAB2 ENSDARG00000074577 1 Not determined 2
im:7147241 SEC16B ENSDARG00000052046 5 Not determined 5
im:7163548 KDM3B ENSDARG00000062267 4 Not determined 1
inhbaa INHBA ENSDARG00000012671 None Not determined 3
inhbab INHBA ENSDARG00000024759 2 Normal 3
iqch IQCH ENSDARG00000015476 None Not determined 1
LIN28B LIN28B ENSDARG00000052511 None Not determined 11
LOC100150764 MCHR2 ENSDARG00000088887 None Not determined 1
LOC568543 CA10 ENSDARG00000009568 4 Normal 2
LOC569359 PHF15 ENSDARG00000053389 1 Not determined 1
LOC793956 MKL2 ENSDARG00000088307 2 Not determined 2
MKL2 (2 of 3) MKL2 ENSDARG00000076704 None Not determined 2
nfat5 NFAT5 ENSDARG00000020872 3 Normal 2
NFAT5 (1 of 2) NFAT5 ENSDARG00000014022 2 Not determined 2
nphp3 NPHP3 ENSDARG00000078261 3 Not determined 1
nr4a2a NR4A2 ENSDARG00000017007 None Not determined 2
nr4a2b NR4A2 ENSDARG00000044532 2 Not determined 2
olfm2 OLFM2 ENSDARG00000077847 4 Not determined 1
pcsk2 PCSK2 ENSDARG00000019451 None Not determined 4
phf21a PHF21A ENSDARG00000021378 2 Not determined 1
plcl1 PLCL1 ENSDARG00000067676 2 Not determined 7
prdm13 PRDM13 ENSDARG00000078701 2 Not determined 1
RBM6 RBM6 ENSDARG00000077060 2 Not determined 1
roraa RORA ENSDARG00000031768 1 Not determined 11
rorab RORA ENSDARG00000001910 1 Not determined 11
rxrga RXRG ENSDARG00000005593 None Not determined 3
rxrgb RXRG ENSDARG00000004697 None Not determined 3
si:ch211-149n12.2 TMEM108 ENSDARG00000090230 None Not determined 2
si:ch211-181p13.1 LRP1B ENSDARG00000004789 20 Normal 5
si:ch211-208c6.2 TRIM66 ENSDARG00000054332 2 Not determined 1
si:ch211-255d18.8 CRTC1 ENSDARG00000076076 None Not determined 1
si:dkey-109j17.6 KLHDC8B ENSDARG00000090787 None Not determined 1
si:dkey-165n16.5 MCHR2 ENSDARG00000007842 None Not determined 1
si:dkey-174m14.3 BEGAIN ENSDARG00000043673 1 Normal 1
si:dkey-184d2.1 LRP1B ENSDARG00000061517 5 Not determined 5
si:dkey-23n7.9 PHF21A ENSDARG00000006878 1 Not determined 1
si:dkeyp-122a9.3 LRP1B ENSDARG00000094171 9 Normal 5
slc14a2 SLC14A2 ENSDARG00000051914 2 Not determined 4
TMEM38B TMEM38B ENSDARG00000041562 None Not determined 5
tra2b TRA2B ENSDARG00000002168 None Not determined 1
trmt11 TRMT11 ENSDARG00000040033 1 Not determined 1
VGLL3 VGLL3 ENSDARG00000038305 1 Not determined 4
wu:fl04e06 MKL2 ENSDARG00000076867 9 Not determined 2
zgc:101011 TMEM18 ENSDARG00000036704 None Not determined 7
zgc:153637 CRTC1 ENSDARG00000076068 1 Not determined 1
zgc:85900 OLFM2 ENSDARG00000007015 None Not determined 1

The following reported genes could not be linked automatically to a zebrafish gene:

  • C13orf16
  • C6orf173
  • FUSSEL18
  • PXMP3
  • ZNF483
* quick link - http://q.sanger.ac.uk/gehn1x9j