GWAS

(GWAS data used on the Zebrafish Mutation Project Web site comes from http://www.genome.gov/gwastudies/.)

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.

The human homologues of the following genes have been identified in this study:

Gene name Reported Gene Ensembl ID Alleles found Associated phenotype Study Count
adcy3 ADCY3 ENSDARG00000017437 2 Not determined 6
ADCY3 (1 of 2) ADCY3 ENSDARG00000077145 None Not determined 6
atxn2l ATXN2L ENSDARG00000011597 3 Not determined 1
bdnf BDNF ENSDARG00000018817 None Not determined 5
cadm2a CADM2 ENSDARG00000009930 2 Not determined 3
cbx1a CBX1 ENSDARG00000004189 None Not determined 2
cbx1b CBX1 ENSDARG00000054442 None Not determined 2
CDC37 AC138894.2 ENSDARG00000040126 None Not determined 1
etv5a ETV5 ENSDARG00000069763 2 Not determined 3
fancl FANCL ENSDARG00000007885 1 Not determined 1
fto FTO ENSDARG00000044216 2 Not determined 32
GIPR GIPR ENSDARG00000025478 2 Not determined 5
gnpda2 GNPDA2 ENSDARG00000024443 2 Not determined 2
gtf3aa GTF3A ENSDARG00000030267 None Not determined 1
gtf3ab GTF3A ENSDARG00000071583 None Not determined 1
hmga1 HMGA1 ENSDARG00000028335 1 Not determined 9
hmgcra HMGCR ENSDARG00000052734 1 Not determined 9
hmgcrb HMGCR ENSDARG00000059301 1 Not determined 9
hnf4g HNF4G ENSDARG00000071565 1 Not determined 2
htr1aa HTR1A ENSDARG00000093745 None Not determined 2
htr1ab HTR1A ENSDARG00000057098 None Not determined 2
im:7147241 SEC16B ENSDARG00000052046 5 Not determined 5
KCTD15 KCTD15 ENSDARG00000058255 None Not determined 5
kctd15a KCTD15 ENSDARG00000045893 None Not determined 5
lmx1b.1 LMX1B ENSDARG00000068365 3 Not determined 1
lmx1b.2 LMX1B ENSDARG00000019306 None Not determined 1
LOC100002893 SLC39A8 ENSDARG00000087905 None Not determined 4
LOC100006044 FAIM2 ENSDARG00000039444 None Not determined 4
LOC557823 ZC3H4 ENSDARG00000078355 1 Not determined 2
LOC568677 TUB ENSDARG00000062165 1 Not determined 1
LOC570207 GPRC5B ENSDARG00000077080 None Not determined 2
map2k5 MAP2K5 ENSDARG00000011851 6 Not determined 4
mc4r MC4R ENSDARG00000015515 3 2 normal 14
mtch2 MTCH2 ENSDARG00000019732 None Not determined 2
mtif3 MTIF3 ENSDARG00000039649 1 Not determined 1
ndufs3 NDUFS3 ENSDARG00000015385 1 Not determined 1
negr1 NEGR1 ENSDARG00000021607 None Not determined 6
NEGR1 (2 of 2) NEGR1 ENSDARG00000091309 None Not determined 6
NP_001122252.1 IQCK ENSDARG00000076831 None Not determined 1
nrxn3a NRXN3 ENSDARG00000043746 7 Not determined 5
nrxn3b NRXN3 ENSDARG00000062693 6 Not determined 5
ntm NEGR1 ENSDARG00000018065 None Not determined 6
nudt3a NUDT3 ENSDARG00000016256 2 Normal 2
nudt3b NUDT3 ENSDARG00000042123 None Not determined 2
pomca POMC ENSDARG00000043135 None Not determined 4
pomcb POMC ENSDARG00000069307 1 Not determined 4
prkd1 PRKD1 ENSDARG00000075949 2 Not determined 2
sh2b1 SH2B1 ENSDARG00000057679 2 Not determined 4
si:ch211-113p18.5 TMEM160 ENSDARG00000069649 1 Normal 1
si:ch211-160l17.2 PTBP2 ENSDARG00000015901 None Not determined 3
si:ch211-181p13.1 LRP1B ENSDARG00000004789 20 Normal 5
si:ch211-191j22.6 QPCTL ENSDARG00000062293 None Not determined 3
si:ch211-196g2.5 SULT1A2 ENSDARG00000094996 1 Not determined 3
si:ch211-196g2.6 SULT1A2 ENSDARG00000079079 2 Not determined 3
si:ch211-202h22.5 GPRC5B ENSDARG00000075141 None Not determined 2
si:dkey-149j18.2 QPCTL ENSDARG00000061691 None Not determined 3
si:dkey-184d2.1 LRP1B ENSDARG00000061517 5 Not determined 5
si:dkey-206l1.5 ADCY9 ENSDARG00000069419 None Not determined 2
si:dkey-208k4.2 GTF3A ENSDARG00000040022 2 Not determined 1
si:dkey-267j14.4 TNNI3K ENSDARG00000086933 None Not determined 2
si:dkey-4c23.7 CADM2 ENSDARG00000062633 1 Not determined 3
si:dkeyp-122a9.3 LRP1B ENSDARG00000094171 9 Normal 5
SLC39A8 (1 of 2) SLC39A8 ENSDARG00000056757 1 Normal 4
sult1st1 SULT1A2 ENSDARG00000028275 None Not determined 3
sult1st2 SULT1A2 ENSDARG00000041540 1 Not determined 3
sult1st3 SULT1A2 ENSDARG00000018361 3 1 phenotype 3
sult1st4 SULT1A2 ENSDARG00000003181 1 Not determined 3
sult1st5 SULT1A2 ENSDARG00000003475 None Not determined 3
sult1st6 SULT1A2 ENSDARG00000006811 None Not determined 3
tfap2b TFAP2B ENSDARG00000012667 1 Not determined 5
tufm TUFM ENSDARG00000041088 1 Not determined 1
zgc:101011 TMEM18 ENSDARG00000036704 None Not determined 7
zgc:110143 FAIM2 ENSDARG00000038784 3 Not determined 4
zgc:113074 PTBP2 ENSDARG00000015230 2 Not determined 3
zgc:153948 HMGA1 ENSDARG00000070951 2 Not determined 9
zgc:175248 PRKD1 ENSDARG00000013544 None Not determined 2
ZNF608 ZNF608 ENSDARG00000075823 2 Not determined 3

The following reported genes could not be linked automatically to a zebrafish gene:

  • APOB48R
  • CUGBP1
  • FLJ35779
  • KIAA1505
  • LBXCOR1
  • LRRN6C
  • RBJ
  • RPL27A
* quick link - http://q.sanger.ac.uk/th430srz