GWAS

(GWAS data used on the Zebrafish Mutation Project Web site comes from http://www.genome.gov/gwastudies/.)

Biological, clinical and population relevance of 95 loci for blood lipids.

The human homologues of the following genes have been identified in this study:

Gene name Reported Gene Ensembl ID Alleles found Associated phenotype Study Count
abca1a ABCA1 ENSDARG00000074635 9 Not determined 13
abca5 ABCA8 ENSDARG00000074041 4 Not determined 1
abcg5 ABCG5 ENSDARG00000063078 3 Normal 2
abcg8 ABCG8 ENSDARG00000063059 4 Not determined 4
AFF1 AFF1 ENSDARG00000086044 1 Not determined 4
ampd3 AMPD3 ENSDARG00000032469 None Not determined 1
angptl3 ANGPTL3 ENSDARG00000044365 None Not determined 7
ankrd55 ANKRD55 ENSDARG00000053869 4 Not determined 6
apoa1 APOA1 ENSDARG00000012076 1 Not determined 13
apoa1 APOA4 ENSDARG00000012076 1 Not determined 11
apoa1 APOA5 ENSDARG00000012076 1 Not determined 22
apoa4 APOA1 ENSDARG00000040298 1 Not determined 13
apoa4 APOA4 ENSDARG00000040298 1 Not determined 11
apoa4 APOA5 ENSDARG00000040298 1 Not determined 22
apob APOB ENSDARG00000042780 7 Not determined 17
apobl APOB ENSDARG00000022767 6 Not determined 17
apoeb APOE ENSDARG00000040295 None Not determined 42
arl15a ARL15 ENSDARG00000076040 None Not determined 3
arl15b ARL15 ENSDARG00000057995 1 Not determined 3
brap BRAP ENSDARG00000008560 3 Not determined 4
capn3 CAPN3 ENSDARG00000041864 2 Not determined 1
celsr1a CELSR2 ENSDARG00000069185 3 Not determined 17
CELSR2 CELSR2 ENSDARG00000088231 3 Not determined 17
celsr2l CELSR2 ENSDARG00000019726 1 Not determined 17
cetp CETP ENSDARG00000030872 1 Not determined 27
cited2 CITED2 ENSDARG00000030905 None Not determined 5
COBLL1 (2 of 2) COBLL1 ENSDARG00000089858 None Not determined 3
COBLL1 (1 of 2) COBLL1 ENSDARG00000088979 None Not determined 3
cyp26a1 CYP26A1 ENSDARG00000033999 2 Normal 2
cyp7a1a CYP7A1 ENSDARG00000069018 1 Not determined 1
dhx38 DHX38 ENSDARG00000053946 1 Not determined 2
dnah9l DNAH11 ENSDARG00000062630 8 Not determined 5
DOCK6 DOCK6 ENSDARG00000035706 4 Normal 2
dock7 DOCK7 ENSDARG00000078675 5 Not determined 5
ergic3 ERGIC3 ENSDARG00000038074 None Not determined 1
evi5 EVI5 ENSDARG00000070839 None Not determined 3
fads2 FADS2 ENSDARG00000019532 None Not determined 15
FRK FRK ENSDARG00000027807 None Not determined 3
hmgcra HMGCR ENSDARG00000052734 1 Not determined 9
hmgcrb HMGCR ENSDARG00000059301 1 Not determined 9
hnf1a HNF1A ENSDARG00000009470 None Not determined 21
hnf4a HNF4A ENSDARG00000021494 None Not determined 8
irf2bp2a IRF2BP2 ENSDARG00000004702 1 Not determined 3
irf2bp2b IRF2BP2 ENSDARG00000006275 1 Not determined 3
jmjd1c JMJD1C ENSDARG00000079939 6 Not determined 11
klhl8 KLHL8 ENSDARG00000015344 2 Not determined 1
lactb LACTB ENSDARG00000040803 1 Not determined 2
ldlr LDLR ENSDARG00000029476 1 Not determined 15
LDLR (2 of 2) LDLR ENSDARG00000089730 None Not determined 15
ldlrap1a LDLRAP1 ENSDARG00000004311 None Not determined 1
ldlrap1b LDLRAP1 ENSDARG00000039750 None Not determined 1
lipc LIPC ENSDARG00000053476 2 Not determined 24
LIPC (2 of 2) LIPC ENSDARG00000090486 None Not determined 24
lipg LIPG ENSDARG00000031044 1 Not determined 9
LOC100002893 SLC39A8 ENSDARG00000087905 None Not determined 4
LOC100331214 LPL ENSDARG00000034667 None Not determined 21
LOC100332911 GPAM ENSDARG00000074169 2 Not determined 1
LOC100333044 GCKR ENSDARG00000086620 None Not determined 39
LOC100334139 PGS1 ENSDARG00000091534 None Not determined 1
LOC556502 ADM ENSDARG00000015263 1 Not determined 5
LOC556578 AMPD3 ENSDARG00000005800 1 Normal 1
LOC559097 CYP7A1 ENSDARG00000004051 None Not determined 1
LOC559281 IRS1 ENSDARG00000054087 1 Not determined 7
LOC560359 CBLN3 ENSDARG00000063376 None Not determined 1
LOC569968 FRMD5 ENSDARG00000079622 2 Not determined 2
LOC570100 ADM ENSDARG00000069027 None Not determined 5
LOC571586 JMJD1C ENSDARG00000077805 5 Not determined 11
LOC793137 LCAT ENSDARG00000062375 None Not determined 6
LOC794381 NAT2 ENSDARG00000036066 None Not determined 4
LOC795256 NAT2 ENSDARG00000036067 None Not determined 4
lpl LPL ENSDARG00000087697 1 Not determined 21
LPL (1 of 2) LPL ENSDARG00000091659 None Not determined 21
lrp4 LRP4 ENSDARG00000090535 2 Not determined 3
macf1 MACF1 ENSDARG00000028533 13 Not determined 1
mafba MAFB ENSDARG00000017121 None Not determined 5
mafbb MAFB ENSDARG00000070542 1 Not determined 5
mc4r MC4R ENSDARG00000015515 3 2 normal 14
mhc1uba HFE ENSDARG00000075963 None Not determined 20
mhc1ze HFE ENSDARG00000074765 None Not determined 20
mhc1zel HFE ENSDARG00000092162 1 Not determined 20
mmab MMAB ENSDARG00000068344 1 Not determined 4
mvk MVK ENSDARG00000004130 None Not determined 4
NPC1L1 NPC1L1 ENSDARG00000077891 6 Normal 1
NP_919406.1 HFE ENSDARG00000086877 2 Not determined 20
nr1h3 NR1H3 ENSDARG00000043170 None Not determined 3
osbpl7 OSBPL7 ENSDARG00000012981 3 Not determined 2
pabpc4 PABPC4 ENSDARG00000059259 None Not determined 2
pbx4 PBX4 ENSDARG00000052150 None Not determined 4
PBX4 (1 of 2) PBX4 ENSDARG00000091547 None Not determined 4
PCSK9 PCSK9 ENSDARG00000074185 1 Not determined 10
PGS1 (1 of 2) PGS1 ENSDARG00000075857 2 Not determined 1
pla2g6 PLA2G6 ENSDARG00000060921 1 Not determined 4
plg LPA ENSDARG00000023111 2 Not determined 10
pltp PLTP ENSDARG00000035768 1 Not determined 5
ppp1r3b PPP1R3B ENSDARG00000044691 None Not determined 9
Q8MHB3_DANRE HFE ENSDARG00000076734 None Not determined 20
Q8MHB6_DANRE HFE ENSDARG00000088022 None Not determined 20
rab3gap1 RAB3GAP1 ENSDARG00000086726 1 Not determined 2
RAF1 (1 of 3) RAF1 ENSDARG00000092302 None Not determined 2
raf1a RAF1 ENSDARG00000009875 None Not determined 2
raf1b RAF1 ENSDARG00000059406 1 Not determined 2
rps3a RPS3A ENSDARG00000035692 None Not determined 1
sbno1 SBNO1 ENSDARG00000078969 1 Not determined 3
scarb1 SCARB1 ENSDARG00000042697 None Not determined 5
si:ch1073-189o9.1 MLXIPL ENSDARG00000089107 None Not determined 13
si:ch211-10e2.5 CBLN3 ENSDARG00000068232 None Not determined 1
si:ch211-212d10.4 CILP2 ENSDARG00000013687 2 Not determined 5
si:ch211-287j19.6 HFE ENSDARG00000001470 1 Not determined 20
si:ch211-49j11.1 UBASH3B ENSDARG00000061243 3 Not determined 1
si:ch211-69m14.1 FRMD5 ENSDARG00000075942 6 Not determined 2
si:ch73-138e16.6 ZNF664 ENSDARG00000074789 1 Not determined 2
si:ch73-213j4.4 HFE ENSDARG00000092731 None Not determined 20
si:ch73-60e21.3 LRP1 ENSDARG00000029146 9 Not determined 6
si:dkey-12h9.6 TMEM57 ENSDARG00000056092 1 Not determined 3
si:dkey-12h9.9 CAPN3 ENSDARG00000043035 2 Not determined 1
si:dkey-159a18.1 SORT1 ENSDARG00000056145 1 Not determined 13
si:dkey-162b3.1 GALNT2 ENSDARG00000003829 4 Not determined 8
si:dkey-205h13.2 CILP2 ENSDARG00000089429 1 Not determined 5
si:dkey-222k23.2 HAVCR1 ENSDARG00000091692 None Not determined 2
si:dkey-222k23.2 TIMD4 ENSDARG00000091692 None Not determined 2
si:dkey-222k23.4 HAVCR1 ENSDARG00000077257 2 Not determined 2
si:dkey-222k23.4 TIMD4 ENSDARG00000077257 2 Not determined 2
si:dkey-233k19.3 DNAH11 ENSDARG00000094282 4 Not determined 5
si:dkey-242g16.2 PPP1R3B ENSDARG00000069377 None Not determined 9
si:dkey-258f14.3 LDLR ENSDARG00000075974 None Not determined 15
si:dkey-283b15.3 MACF1 ENSDARG00000089435 2 Not determined 1
si:dkey-30k22.7 CELSR2 ENSDARG00000037286 3 Not determined 17
si:dkey-48h7.2 PDE3A ENSDARG00000004227 1 Not determined 7
si:dkey-6h5.1 DNAH11 ENSDARG00000077384 8 Not determined 5
si:dkey-71h2.2 LDLRAP1 ENSDARG00000043394 None Not determined 1
si:dkey-7f3.15 APOA1 ENSDARG00000094929 None Not determined 13
si:dkey-7f3.15 APOA4 ENSDARG00000094929 None Not determined 11
si:dkey-7f3.15 APOA5 ENSDARG00000094929 None Not determined 22
si:dkeyp-106c3.3 APOB ENSDARG00000093159 None Not determined 17
si:dkeyp-88f5.1 APOB ENSDARG00000075016 3 Not determined 17
si:rp71-1f1.4 NAT2 ENSDARG00000092476 None Not determined 4
si:rp71-1f1.5 NAT2 ENSDARG00000091672 None Not determined 4
si:rp71-1f1.6 NAT2 ENSDARG00000089278 None Not determined 4
si:rp71-39b20.7 ANGPTL4 ENSDARG00000035859 1 Not determined 2
si:rp71-80a19.2 MAP3K1 ENSDARG00000088180 None Not determined 5
SLC39A8 (1 of 2) SLC39A8 ENSDARG00000056757 1 Normal 4
sort1a SORT1 ENSDARG00000029402 None Not determined 13
sort1b SORT1 ENSDARG00000056252 7 Not determined 13
sox7 PINX1 ENSDARG00000030125 None Not determined 3
spty2d1 SPTY2D1 ENSDARG00000033889 2 Not determined 1
st3gal4 ST3GAL4 ENSDARG00000041006 3 Not determined 2
stard3 STARD3 ENSDARG00000017809 None Not determined 1
tmem57a TMEM57 ENSDARG00000005625 2 Not determined 3
tmem57b TMEM57 ENSDARG00000012741 2 Not determined 3
tomm20b TOMM20 ENSDARG00000044636 None Not determined 3
top1 TOP1 ENSDARG00000086775 None Not determined 1
top1l TOP1 ENSDARG00000070545 3 1 phenotype 1
top1mt TOP1 ENSDARG00000027824 2 Not determined 1
trib1 TRIB1 ENSDARG00000076142 1 Not determined 12
trps1 TRPS1 ENSDARG00000068028 2 Not determined 4
ube2l3a UBE2L3 ENSDARG00000019188 None Not determined 8
ube2l3b UBE2L3 ENSDARG00000027141 None Not determined 8
wu:fe37d09 HIST1H4C ENSDARG00000086555 None Not determined 1
wu:fe37d09 HIST1H4C ENSDARG00000091313 None Not determined 1
wu:fe38f03 HIST1H4C ENSDARG00000074631 None Not determined 1
wu:fe38f03 HIST1H4C ENSDARG00000075366 None Not determined 1
wu:fe38f03 HIST1H4C ENSDARG00000087543 None Not determined 1
wu:fe38f03 HIST1H4C ENSDARG00000089684 None Not determined 1
wu:fe38f03 HIST1H4C ENSDARG00000090591 None Not determined 1
xkr6 XKR6 ENSDARG00000043410 2 Not determined 3
XKR6 (2 of 2) XKR6 ENSDARG00000020443 None Not determined 3
zgc:101040 NAT2 ENSDARG00000005176 None Not determined 4
zgc:101577 C6orf106 ENSDARG00000078075 None Not determined 4
zgc:103601 NAT2 ENSDARG00000036068 1 Not determined 4
zgc:110064 APOE ENSDARG00000086370 None Not determined 42
zgc:110783 MOSC1 ENSDARG00000070487 None Not determined 3
zgc:112992 APOA5 ENSDARG00000086281 None Not determined 22
zgc:112992 APOA1 ENSDARG00000086281 None Not determined 13
zgc:112992 APOA4 ENSDARG00000086281 None Not determined 11
zgc:123269 CCDC92 ENSDARG00000041750 3 Normal 1
zgc:136614 HFE ENSDARG00000069471 None Not determined 20
zgc:165555 HIST1H4C ENSDARG00000086076 None Not determined 1
zgc:165555 HIST1H4C ENSDARG00000087472 None Not determined 1
zgc:165555 HIST1H4C ENSDARG00000087670 None Not determined 1
zgc:165555 HIST1H4C ENSDARG00000089437 None Not determined 1
zgc:165555 HIST1H4C ENSDARG00000089737 None Not determined 1
zgc:165555 HIST1H4C ENSDARG00000089823 None Not determined 1
zgc:165555 HIST1H4C ENSDARG00000090149 None Not determined 1
zgc:165555 HIST1H4C ENSDARG00000090521 None Not determined 1
zgc:165555 HIST1H4C ENSDARG00000090941 None Not determined 1
zgc:165555 HIST1H4C ENSDARG00000091011 None Not determined 1
zgc:165555 HIST1H4C ENSDARG00000091446 None Not determined 1
zgc:171581 ABCA1 ENSDARG00000079009 5 Not determined 13
zgc:173742 TOP1 ENSDARG00000004529 None Not determined 1
zgc:194131 APOA4 ENSDARG00000020866 2 Not determined 11
zgc:194131 APOA5 ENSDARG00000020866 2 Not determined 22
zgc:194131 APOA1 ENSDARG00000020866 2 Not determined 13
zgc:195004 UBASH3B ENSDARG00000077399 2 Not determined 1
zgc:56306 IRS1 ENSDARG00000037099 1 Not determined 7
zgc:64115 HFE ENSDARG00000036588 2 Not determined 20
zgc:77112 PPP1R3B ENSDARG00000015657 None Not determined 9
zgc:85932 CAPN3 ENSDARG00000055094 1 Not determined 1
zgc:92647 HAVCR1 ENSDARG00000040178 None Not determined 2
zgc:92647 TIMD4 ENSDARG00000040178 None Not determined 2
ZNF648 ZNF648 ENSDARG00000087900 None Not determined 1

The following reported genes could not be linked automatically to a zebrafish gene:

  • ABO
  • ABO
  • APOC1
  • APOC1
  • APOC1
  • APOC1
  • APOC2
  • APOC2
  • APOC2
  • APOC2
  • APOC3
  • APOC3
  • APOC3
  • APOC3
  • CMIP
  • CSPG3
  • CSPG3
  • CSPG3
  • CTF1
  • FADS1
  • FADS1
  • FADS1
  • FADS1
  • FADS3
  • FADS3
  • FADS3
  • FADS3
  • FLJ36070
  • FUT2
  • GVI1
  • HLA
  • HLA
  • HLA
  • HP
  • HP
  • HPR
  • HPR
  • IDOL
  • IDOL
  • KIAA0323
  • KLF14
  • LILRA3
  • LILRB2
  • LOC55908
  • MSL2L1
  • PLEC1
  • PLEC1
  • PSRC1
  • PSRC1
  • TTC39B
  • TTC39B
  • TYW1B
* quick link - http://q.sanger.ac.uk/snhewho4