GWAS

(GWAS data used on the Zebrafish Mutation Project Web site comes from http://www.genome.gov/gwastudies/.)

Genome-wide association identifies ATOH7 as a major gene determining human optic disc size.

The human homologues of the following genes have been identified in this study:

Gene name Reported Gene Ensembl ID Alleles found Associated phenotype Study Count
atoh1b ATOH7 ENSDARG00000033400 1 Not determined 3
atoh1c ATOH7 ENSDARG00000039602 None Not determined 3
atoh7 ATOH7 ENSDARG00000069552 1 Not determined 3
esrrd ESRRG ENSDARG00000015064 None Not determined 4
esrrga ESRRG ENSDARG00000004861 2 Not determined 4
esrrgb ESRRG ENSDARG00000011696 None Not determined 4
LOC100332468 PDE2A ENSDARG00000079064 None Not determined 2
LOC566750 NMUR2 ENSDARG00000022570 2 Not determined 2
myh9a MYH9 ENSDARG00000063295 6 Not determined 3
MYPN MYPN ENSDARG00000076485 1 Not determined 1
NP_001139235.1 TSHR ENSDARG00000037195 2 Not determined 4
obscn MYPN ENSDARG00000043309 7 Normal 1
PDE2A (2 of 2) PDE2A ENSDARG00000091508 None Not determined 2
pex14 PEX14 ENSDARG00000028322 2 Not determined 1
RFTN1 (1 of 2) RFTN1 ENSDARG00000086499 1 Not determined 1
scfd2 SCFD2 ENSDARG00000040005 None Not determined 1
si:ch211-150d5.2 MYH9 ENSDARG00000001014 2 Not determined 3
si:ch211-155k24.8 RFTN1 ENSDARG00000070831 None Not determined 1
si:ch211-181p13.1 LRP1B ENSDARG00000004789 20 Normal 5
si:ch73-249k16.4 SCFD2 ENSDARG00000093336 None Not determined 1
si:dkey-184d2.1 LRP1B ENSDARG00000061517 5 Not determined 5
si:dkey-90m5.1 MYPN ENSDARG00000040009 1 Not determined 1
si:dkeyp-122a9.3 LRP1B ENSDARG00000094171 9 Normal 5
six1a SIX1 ENSDARG00000039304 1 Not determined 4
six1b SIX1 ENSDARG00000026473 1 Not determined 4
six9 SIX1 ENSDARG00000068407 None Not determined 4
zgc:112210 PBLD ENSDARG00000016704 None Not determined 2
zgc:113291 PBLD ENSDARG00000026359 2 Not determined 2

The following reported genes could not be linked automatically to a zebrafish gene:

  • DENND2A
  • hCG_1820801
  • HSP90B3P
  • LOC401447
  • LOC643153
  • LOC730245
  • MEG3
  • ZNF157
* quick link - http://q.sanger.ac.uk/bg5apjhl