GWAS

(GWAS data used on the Zebrafish Mutation Project Web site comes from http://www.genome.gov/gwastudies/.)

A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium.

The human homologues of the following genes have been identified in this study:

Gene name Reported Gene Ensembl ID Alleles found Associated phenotype Study Count
ak3 AK3 ENSDARG00000058226 2 Normal 3
arhgef3 ARHGEF3 ENSDARG00000013834 2 Not determined 6
arhgef3l ARHGEF3 ENSDARG00000037554 1 Not determined 6
BAK1 (2 of 2) BAK1 ENSDARG00000089995 None Not determined 7
baxb BAK1 ENSDARG00000030881 None Not determined 7
bysl BYSL ENSDARG00000001057 None Not determined 3
cd226 CD226 ENSDARG00000045391 1 Not determined 5
cmyb MYB ENSDARG00000053666 2 Not determined 12
ehd3 EHD3 ENSDARG00000007869 2 Not determined 3
hbs1l HBS1L ENSDARG00000036778 1 Not determined 11
jmjd1c JMJD1C ENSDARG00000079939 5 Not determined 11
LOC100004576 TAOK1 ENSDARG00000069603 1 Not determined 4
LOC100334915 TAOK1 ENSDARG00000089925 None Not determined 4
LOC571586 JMJD1C ENSDARG00000077805 9 Not determined 11
mhc1uba HFE ENSDARG00000075963 None Not determined 20
mhc1ze HFE ENSDARG00000074765 None Not determined 20
mhc1zel HFE ENSDARG00000092162 1 Not determined 20
NP_919406.1 HFE ENSDARG00000086877 1 Not determined 20
ptpn11a PTPN11 ENSDARG00000020334 2 Not determined 8
Q8MHB3_DANRE HFE ENSDARG00000076734 None Not determined 20
Q8MHB6_DANRE HFE ENSDARG00000088022 1 Not determined 20
si:ch211-231a1.5 TMPRSS6 ENSDARG00000094087 None Not determined 14
si:ch211-287j19.6 HFE ENSDARG00000001470 2 Not determined 20
si:ch73-213j4.4 HFE ENSDARG00000092731 None Not determined 20
si:dkey-19f21.3 DNM3 ENSDARG00000032238 3 Not determined 6
si:dkey-65b12.4 WDR66 ENSDARG00000059855 3 Not determined 4
si:rp71-11b17.10 TMCC2 ENSDARG00000046007 None Not determined 2
si:rp71-17i16.5 PIK3CG ENSDARG00000037527 None Not determined 5
TFR2 (2 of 2) TFR2 ENSDARG00000018406 2 Not determined 4
TFR2 (1 of 2) TFR2 ENSDARG00000089980 None Not determined 4
tpm1 TPM1 ENSDARG00000087402 1 Not determined 3
tpm3 TPM1 ENSDARG00000005162 4 Not determined 3
tpma TPM1 ENSDARG00000033683 None Not determined 3
zgc:100789 BET1L ENSDARG00000032037 None Not determined 4
zgc:101654 ORMDL3 ENSDARG00000025555 1 Not determined 14
zgc:103502 CCND3 ENSDARG00000027391 None Not determined 6
zgc:112307 TAOK1 ENSDARG00000077159 1 Not determined 4
zgc:136614 HFE ENSDARG00000069471 None Not determined 20
zgc:153993 BAK1 ENSDARG00000068102 None Not determined 7
zgc:64115 HFE ENSDARG00000036588 4 Not determined 20
zgc:77033 PIK3CG ENSDARG00000017757 2 Not determined 5

The following reported genes could not be linked automatically to a zebrafish gene:

  • FBX07
  • GSDMA
  • SIRPA
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