GWAS

(GWAS data used on the Zebrafish Mutation Project Web site comes from http://www.genome.gov/gwastudies/.)

Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.

The human homologues of the following genes have been identified in this study:

Gene name Reported Gene Ensembl ID Alleles found Associated phenotype Study Count
bach2 BACH2 ENSDARG00000004074 2 Not determined 14
cobl COBL ENSDARG00000004532 1 Not determined 1
ctsh CTSH ENSDARG00000041108 2 Not determined 3
ctskl CTSH ENSDARG00000042753 2 Not determined 3
erbb3a ERBB3 ENSDARG00000006202 1 Not determined 8
erbb3b ERBB3 ENSDARG00000036993 7 Not determined 8
glis3 GLIS3 ENSDARG00000069726 5 Not determined 6
ifih1 IFIH1 ENSDARG00000018553 1 Not determined 7
il10 IL10 ENSDARG00000078147 4 Normal 11
ins INS ENSDARG00000035350 None Not determined 5
insb INS ENSDARG00000034610 None Not determined 5
LOC557210 BACH2 ENSDARG00000036569 4 Not determined 14
pgm1 PGM1 ENSDARG00000013561 4 Not determined 2
prkcq PRKCQ ENSDARG00000034173 3 Not determined 6
ptpn22 PTPN22 ENSDARG00000075062 5 Not determined 17
ptpn2a PTPN2 ENSDARG00000016481 4 Not determined 13
ptpn2b PTPN2 ENSDARG00000035986 2 Not determined 13
SH2B3 (1 of 2) SH2B3 ENSDARG00000069958 None Not determined 19
si:ch211-160b7.1 CTLA4 ENSDARG00000095070 None Not determined 9
si:ch211-207g17.1 COBL ENSDARG00000091006 2 Not determined 1
si:dkeyp-1e8.2 SH2B3 ENSDARG00000093095 None Not determined 19
zgc:101654 ORMDL3 ENSDARG00000025555 1 Not determined 14
zgc:110239 CTSH ENSDARG00000077664 1 Not determined 3
zgc:56230 CLEC16A ENSDARG00000038094 3 Not determined 13

The following reported genes could not be linked automatically to a zebrafish gene:

  • C10orf59
  • C1QTNF6
  • C6orf173
  • CD69
  • IL2
  • IL27
  • IL2RA
  • MHC
  • UBASH3A
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