GWAS

(GWAS data used on the Zebrafish Mutation Project Web site comes from http://www.genome.gov/gwastudies/.)

Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes.

The human homologues of the following genes have been identified in this study:

Gene name Reported Gene Ensembl ID Alleles found Associated phenotype Study Count
adamts9 ADAMTS9 ENSDARG00000077778 5 Not determined 5
camk1d CAMK1D ENSDARG00000017446 1 Not determined 4
cdc123 CDC123 ENSDARG00000075025 1 Not determined 5
cdkal1 CDKAL1 ENSDARG00000022122 None Not determined 23
cdkn2b CDKN2B ENSDARG00000037262 None Not determined 30
cdkn2b CDKN2A ENSDARG00000037262 None Not determined 25
fto FTO ENSDARG00000044216 2 Not determined 32
igf2bp2a IGF2BP2 ENSDARG00000003421 1 Not determined 12
igf2bp2b IGF2BP2 ENSDARG00000061661 2 Not determined 12
jazf1a JAZF1 ENSDARG00000036243 1 Not determined 8
jazf1b JAZF1 ENSDARG00000056793 None Not determined 8
kcnj11 KCNJ11 ENSDARG00000051880 None Not determined 5
kcnj11l KCNJ11 ENSDARG00000031438 None Not determined 5
notch2 NOTCH2 ENSDARG00000092960 2 Not determined 1
NOTCH2NL NOTCH2 ENSDARG00000089347 None Not determined 1
NP_001108566.1 NOTCH2 ENSDARG00000043130 2 Not determined 1
pparg PPARG ENSDARG00000031848 2 2 normal 8
tcf7l2 TCF7L2 ENSDARG00000004415 4 Not determined 23
vegfaa VEGFA ENSDARG00000045971 None Not determined 8
vegfab VEGFA ENSDARG00000034700 1 Not determined 8
zgc:113068 THADA ENSDARG00000053082 1 Not determined 10
zgc:172284 CAMK1D ENSDARG00000074905 3 Not determined 4

The following reported genes could not be linked automatically to a zebrafish gene:

  • ADAM30
  • DCD
  • HHEX
  • LGR5
  • SYN2
  • TSPAN8
* quick link - http://q.sanger.ac.uk/b4gtbe5h