trip11

Ensembl ID:
ENSDARG00000078381
ZFIN ID:
ZDB-GENE-030131-9833
Description:
Novel protein similar to H.sapiens TRIP11, thyroid hormone receptor interactor 11 (TRIP11) [Source:U
Human Orthologue:
TRIP11
Human Description:
thyroid hormone receptor interactor 11 [Source:HGNC Symbol;Acc:12305]
Mouse Orthologue:
Trip11
Mouse Description:
thyroid hormone receptor interactor 11 Gene [Source:MGI Symbol;Acc:MGI:1924393]

Alleles

There are 2 alleles of this gene:

Allele name Consequence Status Availability Estimate
sa7228 Nonsense Mutation detected in F1 DNA During 2014
sa7729 Essential Splice Site Mutation detected in F1 DNA During 2014

Mutation Details

Allele Name:
sa7228
Current Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
We currently estimate that this allele will be available during 2014.
Mutation:
T > A
Consequence:
Nonsense
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000109667 Nonsense 846 1984 11 22
ENSDART00000134383 None None 711 None 12
ENSDART00000137576 None None 245 None 5
ENSDART00000146138 None None 192 None 4
Genomic Location:
Chromosome 13 (position 33419534)
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
CCTRAAAACTCAAGCTGTRGAAACACAACAAGMGTTGGAGACCYGTATCT[T/A]GAGAGCAAGTCAAGAGTGTGACTCTCTCAGAAAGTCAGTGGAAGAGAAAG
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa7729
Current Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
We currently estimate that this allele will be available during 2014.
Mutation:
A > T
Consequence:
Essential Splice Site
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000109667 Essential Splice Site 1725 1984 17 22
ENSDART00000134383 Essential Splice Site 452 711 7 12
ENSDART00000137576 None None 245 None 5
ENSDART00000146138 None None 192 None 4
Genomic Location:
Chromosome 13 (position 33410868)
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
GTGTGGATATAYACAGTACATTAATGCTCAATATCTACATCTGTAAACTT[A/T]GATAAACCTGGATGAAGCGAACGCAGCTCTAGAATCTGCCTCTCGCCTCA
Associated Phenotype:
Not determined

GWAS

This gene's human homologue has been identified in the following GWAS studies:

  • Height: Hundreds of variants clustered in genomic loci and biological pathways affect human height. (View Study)
  • Height: Identification of ten loci associated with height highlights new biological pathways in human growth. (View Study)
  • Height: Many sequence variants affecting diversity of adult human height. (View Study)

(GWAS data comes from http://www.genome.gov/gwastudies/.)

Register

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* quick link - http://q.sanger.ac.uk/od8lpn22