grap2b

Ensembl ID:
ENSDARG00000074837
ZFIN ID:
ZDB-GENE-040426-1485
Description:
GRB2-related adaptor protein 2b [Source:RefSeq peptide;Acc:NP_956972]
Human Orthologues:
GRAP2, NCK2
Human Descriptions:
GRB2-related adaptor protein 2 [Source:HGNC Symbol;Acc:4563]
NCK adaptor protein 2 [Source:HGNC Symbol;Acc:7665]
Mouse Orthologue:
Grap2
Mouse Description:
GRB2-related adaptor protein 2 Gene [Source:MGI Symbol;Acc:MGI:1333842]

Alleles

There are 2 alleles of this gene:

Allele name Consequence Status Availability Estimate
sa8216 Nonsense Mutation detected in F1 DNA During 2014
sa14352 Nonsense Available for shipment Available now

Mutation Details

Allele Name:
sa8216
Current Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
We currently estimate that this allele will be available during 2014.
Mutation:
A > T
Consequence:
Nonsense
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000110189 Nonsense 83 249 4 8
Genomic Location:
Chromosome 6 (position 571438)
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
AGTCTGCACAGGATGAGCTGATGTGTCAACCAATAGGAGCCTTCATCATC[A/T]GAGGATCCCAGAGCTCACCTGGGGAYTTYTCCATCTCAGTCAGGTACATG
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa14352
Current Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Mutation:
A > T
Consequence:
Nonsense
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000110189 Nonsense 231 249 8 8
Genomic Location:
Chromosome 6 (position 572721)
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
AGGCCGGAGACGTGATCGAGGTTYTGGATCAGTCCGATCGATCCTGGTGG[A/T]AAGGMGTCCTGCGTGGCAGAACTGGACTSTTCCCCGTCAACTACACCAAT
Associated Phenotype:
Not determined

GWAS

This gene's human homologue has been identified in the following GWAS studies:

  • Addiction: NCK2 is significantly associated with opiates addiction in African-origin men. (View Study)

(GWAS data comes from http://www.genome.gov/gwastudies/.)

Register

If you would like to be informed when the status of this gene changes (for example, a new allele is generated or an allele is made available for distribution) then please enter your details below:

* quick link - http://q.sanger.ac.uk/0jp46tcr