trpc5

Ensembl ID:
ENSDARG00000070504
ZFIN ID:
ZDB-GENE-040812-1
Description:
transient receptor potential cation channel, subfamily C, member 5 [Source:RefSeq peptide;Acc:NP_00
Human Orthologue:
TRPC5
Human Description:
transient receptor potential cation channel, subfamily C, member 5 [Source:HGNC Symbol;Acc:12337]
Mouse Orthologue:
Trpc5
Mouse Description:
transient receptor potential cation channel, subfamily C, member 5 Gene [Source:MGI Symbol;Acc:MGI:1

Alleles

There are 5 alleles of this gene:

Allele name Consequence Status Availability Estimate
sa3325 Essential Splice Site F2 line generated During 2016
sa5799 Essential Splice Site F2 line generated During 2016
sa19436 Nonsense Available for shipment Available now
sa32604 Nonsense Mutation detected in F1 DNA During 2016
sa32603 Nonsense Mutation detected in F1 DNA During 2016

Mutation Details

Allele Name:
sa3325
Current Status:
F2 line generated
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
We currently estimate that this allele will be available during 2016.
Mutation:
G > A
Consequence:
Essential Splice Site
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000040502   None 984 None 13
ENSDART00000131294 Essential Splice Site None 1045 3 12
ENSDART00000140495 Essential Splice Site None 570 3 7
ENSDART00000040502   None 984 None 13
ENSDART00000131294 Essential Splice Site None 1045 3 12
ENSDART00000140495 Essential Splice Site None 570 3 7

The following transcripts of ENSDARG00000070504 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 1 (position 9754049)
Other Location(s):
Assembly Chromosome Position
GRCz10 1 9893835
KASP Assay ID:
554-2635.1 (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
TATCATATATATCAAATGATTATAGCATCTTTTTTTTTTTTCTTCCAGCA[G/A]CATCCATCATGAATCCCATGTCACATCTATACTACAAAAAGAGCAGCTAC
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa5799
Current Status:
F2 line generated
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
We currently estimate that this allele will be available during 2016.
Mutation:
G > A
Consequence:
Essential Splice Site
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000040502   None 984 None 13
ENSDART00000131294 Essential Splice Site None 1045 3 12
ENSDART00000140495 Essential Splice Site None 570 3 7
ENSDART00000040502   None 984 None 13
ENSDART00000131294 Essential Splice Site None 1045 3 12
ENSDART00000140495 Essential Splice Site None 570 3 7

The following transcripts of ENSDARG00000070504 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 1 (position 9754049)
Other Location(s):
Assembly Chromosome Position
GRCz10 1 9893835
KASP Assay ID:
554-2635.1 (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
TAWCATATATATCAAATGATTATAGCATCTTTTTTTTTTTTCTTCCAGCA[G/A]CATCCATCATGAATCCCATGTCACATCTATACTACAAAAAGAGCAGCTAC
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa19436
Current Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Order Allele From EZRC
Mutation:
G > A
Consequence:
Nonsense
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000040502 Nonsense 225 984 2 13
ENSDART00000131294 Nonsense 228 1045 4 12
ENSDART00000140495 Nonsense 228 570 4 7

The following transcripts of ENSDARG00000070504 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 1 (position 9739318)
Other Location(s):
Assembly Chromosome Position
GRCz10 1 9879104
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
None
Flanking Sequence:
ATCGCCCTCTCCAGCGAGGATCCCATCCTGACCGCCTTCAGACTGGGCTG[G/A]GAACTCAAGGAGCTCAGCAAAGTGGAGAACGAGTTTCGGCAGGAGTACGA
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa32604
Current Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
We currently estimate that this allele will be available during 2016.
Mutation:
G > A
Consequence:
Nonsense
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000040502 Nonsense 420 984 5 13
ENSDART00000131294 Nonsense 437 1045 6 12
ENSDART00000140495 Nonsense 437 570 6 7

The following transcripts of ENSDARG00000070504 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 1 (position 9693633)
Other Location(s):
Assembly Chromosome Position
GRCz10 1 9833419
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
None
Flanking Sequence:
GAGATTAAGGAGATGTGGGATGGAGGTTTTAACGAGTACGTCCATGACTG[G/A]TGGAACCTGATGGACTTTGCTATGAATTCTCTCTATTTGGCCACCATTTC
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa32603
Current Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
We currently estimate that this allele will be available during 2016.
Mutation:
T > A
Consequence:
Nonsense
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000040502 Nonsense 760 984 11 13
ENSDART00000131294 Nonsense 781 1045 12 12
ENSDART00000140495   None 570 None 7

The following transcripts of ENSDARG00000070504 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 1 (position 9663780)
Other Location(s):
Assembly Chromosome Position
GRCz10 1 9803566
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
None
Flanking Sequence:
TACGAGGTTTTAGACCTTCTCGGCAACCGAAAGCCTCCCCGGCGGAACTA[T/A]TCATCCAGCAGCGAGGCCACACTTCGAGACGAGGTCAGCGACGACGGCGA
Associated Phenotype:
Not determined

GWAS

This gene's human homologue has been identified in the following GWAS studies:

(GWAS data comes from http://www.genome.gov/gwastudies/.)

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