lrguk

Ensembl ID:
ENSDARG00000069698
ZFIN ID:
ZDB-GENE-050419-232
Description:
leucine-rich repeats and guanylate kinase domain containing [Source:RefSeq peptide;Acc:NP_001116719
Human Orthologue:
LRGUK
Human Description:
leucine-rich repeats and guanylate kinase domain containing [Source:HGNC Symbol;Acc:21964]
Mouse Orthologue:
Lrguk
Mouse Description:
leucine-rich repeats and guanylate kinase domain containing Gene [Source:MGI Symbol;Acc:MGI:1921604]

Alleles

There are 5 alleles of this gene:

Allele name Consequence Status Availability Estimate
sa40261 Essential Splice Site Mutation detected in F1 DNA During 2016
sa20244 Nonsense Available for shipment Available now
sa10454 Essential Splice Site Available for shipment Available now
sa13998 Nonsense Available for shipment Available now
sa20245 Nonsense Available for shipment Available now

Mutation Details

Allele Name:
sa40261
Current Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
We currently estimate that this allele will be available during 2016.
Mutation:
G > T
Consequence:
Essential Splice Site
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000101613 Essential Splice Site 2 730 1 20
Genomic Location (Zv9):
Chromosome 4 (position 14885371)
Other Location(s):
Assembly Chromosome Position
GRCz10 4 15821224
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
None
Flanking Sequence:
AGACAGGAGACCATAGAGACAACAGACAACCAAAACGCACAACAATGGAG[G/T]TAACATATTGTTTACTCGTTTATTACAGCTTTCTCTGACGTCACTTTGTG
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa20244
Current Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Order Allele From EZRC
Mutation:
C > T
Consequence:
Nonsense
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000101613 Nonsense 184 730 7 20
Genomic Location (Zv9):
Chromosome 4 (position 14891797)
Other Location(s):
Assembly Chromosome Position
GRCz10 4 15827650
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
None
Flanking Sequence:
CGGGAAATATGATCAACAAAATTGAAAACCTCCAGACTCTCCACAACCTG[C/T]AAGTTCTGGATTTGTCCTGTAACCGGATTCAAAGCCTCACGGGTCTCCAG
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa10454
Current Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Order Allele From EZRC
Mutation:
A > T
Consequence:
Essential Splice Site
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000101613 Essential Splice Site 242 730 9 20
Genomic Location (Zv9):
Chromosome 4 (position 14892479)
Other Location(s):
Assembly Chromosome Position
GRCz10 4 15828332
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
CACTGAGCTTAAAGTCATTAYYTGGTACTTCATGCCAAYTGCTTTCTTGC[A/T]GGACCATGATGATTATAGGAWAGCTGTCATCTTCCTCCTCCAGCACCTCA
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa13998
Current Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Order Allele From EZRC
Mutation:
G > T
Consequence:
Nonsense
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000101613 Nonsense 361 730 12 20
Genomic Location (Zv9):
Chromosome 4 (position 14895711)
Other Location(s):
Assembly Chromosome Position
GRCz10 4 15831564
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
GTTTTAGTGCYTGCCACACCACCAGGRRGCCCTATTTTGGMGAAGAGGAT[G/T]GACTWGACTATCACTTTGTCACWGAGGAAGAATTTCACAACATGATTCAA
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa20245
Current Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Mutation:
T > A
Consequence:
Nonsense
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000101613 Nonsense 421 730 14 20
Genomic Location (Zv9):
Chromosome 4 (position 14896755)
Other Location(s):
Assembly Chromosome Position
GRCz10 4 15832608
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
None
Flanking Sequence:
TTATACCGGACATTTCTTGTGTTTGCTTCTACACCAGGGAGTGTTCAGCT[T/A]GAAGAACTCGTATTTTGAGCCCCGTTACGTCTTGCTGATTCCCAGCGTTG
Associated Phenotype:
Not determined

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