tiparp

Ensembl ID:
ENSDARG00000061841
ZFIN IDs:
ZDB-GENE-031002-47, ZDB-GENE-031002-47
Description:
TCDD-inducible poly [Source:RefSeq peptide;Acc:NP_001038484]
Human Orthologue:
TIPARP
Human Description:
TCDD-inducible poly(ADP-ribose) polymerase [Source:HGNC Symbol;Acc:23696]
Mouse Orthologues:
Tiparp, Zc3hav1
Mouse Descriptions:
TCDD-inducible poly(ADP-ribose) polymerase Gene [Source:MGI Symbol;Acc:MGI:2159210]
zinc finger CCCH type, antiviral 1 Gene [Source:MGI Symbol;Acc:MGI:1926031]

Alleles

There are 5 alleles of this gene:

Allele name Consequence Status Availability Estimate
sa43140 Nonsense Mutation detected in F1 DNA During 2016
sa15738 Nonsense Available for shipment Available now
sa43141 Nonsense Mutation detected in F1 DNA During 2016
sa36690 Essential Splice Site Mutation detected in F1 DNA During 2016
sa10114 Nonsense Available for shipment Available now

Mutation Details

Allele Name:
sa43140
Current Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
We currently estimate that this allele will be available during 2016.
Mutation:
T > G
Consequence:
Nonsense
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000088673 Nonsense 161 646 1 5
ENSDART00000088675 Nonsense 161 279 2 2
Genomic Location (Zv9):
Chromosome 18 (position 32943868)
Other Location(s):
Assembly Chromosome Position
GRCz10 18 34625413
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
None
Flanking Sequence:
CCAGGAGCGCGACGAGGCGGCGCCCCCCTCCGATGTTTCGGGCTCCAAGT[T/G]AAATGACATCTACACTGCTGAGACTTTGCAGGGAGCAAATTGCCTCGCCA
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa15738
Current Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Mutation:
T > A
Consequence:
Nonsense
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000088673 Nonsense 237 646 1 5
ENSDART00000088675 Nonsense 237 279 2 2
Genomic Location (Zv9):
Chromosome 18 (position 32944096)
Other Location(s):
Assembly Chromosome Position
GRCz10 18 34625641
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
CCAGGGCGTTTGCGTCTATGGCAGTGACTGTGCCCAGCATCACACCGTTT[T/A]ACCTTACCACTGGCAAATCCGCAGAGTAGAWACGCAAATCTGGCAGAGCA
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa43141
Current Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
We currently estimate that this allele will be available during 2016.
Mutation:
A > T
Consequence:
Nonsense
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000088673 Nonsense 277 646 1 5
ENSDART00000088675 Nonsense 277 279 2 2
Genomic Location (Zv9):
Chromosome 18 (position 32944215)
Other Location(s):
Assembly Chromosome Position
GRCz10 18 34625760
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
None
Flanking Sequence:
AACAACTGGAAAGGCTTTATTGCAACCCGGATAACGAACATGTCAGACTT[A/T]AGTTCCTGTAAGTGCTTTTGGTTTATGCCACTTTTCACTAAAATTTTTTT
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa36690
Current Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
We currently estimate that this allele will be available during 2016.
Mutation:
G > T
Consequence:
Essential Splice Site
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000088673 Essential Splice Site 344 646 3 5
ENSDART00000088675   None 279 None 2
Genomic Location (Zv9):
Chromosome 18 (position 32965856)
Other Location(s):
Assembly Chromosome Position
GRCz10 18 34647401
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
None
Flanking Sequence:
CTCTCTCTTTCTTTGCGTAACTCATTTCCTCTCTGCTTCTTCATCCCACA[G/T]CCGGTGGTTCGGCTGATTGAGGAGGCCAGTGGTCGAGGTTTGAAGGAGGT
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa10114
Current Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Mutation:
T > G
Consequence:
Nonsense
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000088673 Nonsense 560 646 5 5
ENSDART00000088675   None 279 None 2
Genomic Location (Zv9):
Chromosome 18 (position 32983678)
Other Location(s):
Assembly Chromosome Position
GRCz10 18 34665223
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
CACGCCACCATGTTCGGCCAAGGCAGCTACTTTGCACGCAAGGCTGTGYA[T/G]TCCCRCAACTTCTCCAAGCGCTCGCCTAATGGTGTGCACTACATGTTCCT
Associated Phenotype:
Not determined

GWAS

This gene's human homologue has been identified in the following GWAS studies:

  • Ovarian cancer: A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24. (View Study)

(GWAS data comes from http://www.genome.gov/gwastudies/.)

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