lss

Ensembl ID:
ENSDARG00000061274
ZFIN ID:
ZDB-GENE-050119-7
Description:
lanosterol synthase [Source:RefSeq peptide;Acc:NP_001077036]
Human Orthologue:
LSS
Human Description:
lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) [Source:HGNC Symbol;Acc:6708]
Mouse Orthologue:
Lss
Mouse Description:
lanosterol synthase Gene [Source:MGI Symbol;Acc:MGI:1336155]

Alleles

There are 6 alleles of this gene:

Allele name Consequence Status Availability Estimate
sa34708 Nonsense Mutation detected in F1 DNA During 2016
sa7203 Nonsense Mutation detected in F1 DNA During 2016
sa41487 Essential Splice Site Mutation detected in F1 DNA During 2016
sa8442 Essential Splice Site Mutation detected in F1 DNA During 2016
sa8616 Essential Splice Site Mutation detected in F1 DNA During 2016
sa34709 Nonsense Mutation detected in F1 DNA During 2016

Mutation Details

Allele Name:
sa34708
Current Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
We currently estimate that this allele will be available during 2016.
Mutation:
C > T
Consequence:
Nonsense
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000087241 Nonsense 235 735 7 22
Genomic Location (Zv9):
Chromosome 9 (position 39538414)
Other Location(s):
Assembly Chromosome Position
GRCz10 9 38676310
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
None
Flanking Sequence:
TTTTGCCCTCCTGGATGCCAGCACACCCCTCCACATTATGGTGCCACTGT[C/T]GACAGGTCTACCTGCCCATGAGCTACTGCTACGCAGTCAGGCTCTCTGCT
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa7203
Current Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
We currently estimate that this allele will be available during 2016.
Mutation:
T > A
Consequence:
Nonsense
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000087241 Nonsense 284 735 8 22
Genomic Location (Zv9):
Chromosome 9 (position 39540745)
Other Location(s):
Assembly Chromosome Position
GRCz10 9 38678641
KASP Assay ID:
554-5331.1 (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
GATTACTCCACTATTGACTGGCCAGCTCAGAGGAACAACGTTGCARCCTG[T/A]GATTTATACACACCRCACAGCAACTTGCTTACTTTCGCTTATTGTGAGTG
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa41487
Current Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
We currently estimate that this allele will be available during 2016.
Mutation:
G > A
Consequence:
Essential Splice Site
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000087241 Essential Splice Site 490 735 15 22
Genomic Location (Zv9):
Chromosome 9 (position 39543450)
Other Location(s):
Assembly Chromosome Position
GRCz10 9 38681346
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
None
Flanking Sequence:
TCCTCAAAGAGAACATTCCCAAGGAAAGGCTTTTTGATGCTGTCAATGTG[G/A]TAATAACCTTACTTGTGTATATACTGTCTGTTTTGAATGCTGACATAAGA
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa8442
Current Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
We currently estimate that this allele will be available during 2016.
Mutation:
T > A
Consequence:
Essential Splice Site
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000087241 Essential Splice Site 490 735 15 22
ENSDART00000087241 Essential Splice Site 490 735 15 22
Genomic Location (Zv9):
Chromosome 9 (position 39543451)
Other Location(s):
Assembly Chromosome Position
GRCz10 9 38681347
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
CCTSAAAGAGAACATTCCCAAGGAAAGGCTTTTTGATGCTGTCAATGTGG[T/A]AATAACCTTACTTGTGTATATACTGTCTGTTTYGAATGCTGAMATAAGAT
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa8616
Current Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
We currently estimate that this allele will be available during 2016.
Mutation:
T > A
Consequence:
Essential Splice Site
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000087241 Essential Splice Site 490 735 15 22
ENSDART00000087241 Essential Splice Site 490 735 15 22
Genomic Location (Zv9):
Chromosome 9 (position 39543451)
Other Location(s):
Assembly Chromosome Position
GRCz10 9 38681347
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
CCTSAAAGAGAACATTCCCAAGGAAAGGCTTTTTGATGCTGTCAATGTGG[T/A]AATAACCTTACTTGTGTATATACTGTCTGTTTYGAATGCTGAMATAAGAT
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa34709
Current Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
We currently estimate that this allele will be available during 2016.
Mutation:
T > A
Consequence:
Nonsense
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000087241 Nonsense 531 735 17 22
Genomic Location (Zv9):
Chromosome 9 (position 39547013)
Other Location(s):
Assembly Chromosome Position
GRCz10 9 38684909
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
None
Flanking Sequence:
AATTCCTGTTAAATGTCTCTTTCAGGTGATATAATGATTGACTACACGTA[T/A]GTTGAGTGCACCTCAGCTGTACTGCAGGCATTGAAACATTTTCACAGCGT
Associated Phenotype:
Not determined

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