lama5

Ensembl ID:
ENSDARG00000058543
ZFIN ID:
ZDB-GENE-030131-9823
Description:
laminin subunit alpha-5 [Source:RefSeq peptide;Acc:NP_001034260]
Human Orthologue:
LAMA5
Human Description:
laminin, alpha 5 [Source:HGNC Symbol;Acc:6485]
Mouse Orthologue:
Lama5
Mouse Description:
laminin, alpha 5 Gene [Source:MGI Symbol;Acc:MGI:105382]

Alleles

There are 17 alleles of this gene:

Allele name Consequence Status Availability Estimate
sa24260 Essential Splice Site Available for shipment Available now
sa9662 Nonsense Available for shipment Available now
sa25193 Essential Splice Site Mutation detected in F1 DNA During 2016
sa18267 Essential Splice Site Available for shipment Available now
sa9446 Nonsense Available for shipment Available now
sa43919 Essential Splice Site Mutation detected in F1 DNA During 2016
sa16193 Essential Splice Site Available for shipment Available now
sa16078 Essential Splice Site Available for shipment Available now
sa37625 Nonsense Mutation detected in F1 DNA During 2016
sa18231 Essential Splice Site Available for shipment Available now
sa43918 Nonsense Mutation detected in F1 DNA During 2016
sa43917 Nonsense Mutation detected in F1 DNA During 2016
sa24259 Nonsense Mutation detected in F1 DNA During 2016
sa29878 Essential Splice Site Mutation detected in F1 DNA During 2016
sa6725 Nonsense Mutation detected in F1 DNA During 2016
sa16872 Nonsense Available for shipment Available now
sa13881 Nonsense Available for shipment Available now

Mutation Details

Allele Name:
sa24260
Current Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Mutation:
T > C
Consequence:
Essential Splice Site
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000045126 Essential Splice Site 311 3664 6 80
Genomic Location (Zv9):
Chromosome 23 (position 9813078)
Other Location(s):
Assembly Chromosome Position
GRCz10 23 9771219
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
None
Flanking Sequence:
ATGGCCACGCTGAGGCCTGTAATGCTCAAGACCCCAATGATCCCTACAAG[T/C]AAGTGACCTTTAAGAATGTTTCATTTATTTATGTGTTTTTAAATGTCAGG
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa9662
Current Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Mutation:
C > A
Consequence:
Nonsense
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000045126 Nonsense 388 3664 8 80
Genomic Location (Zv9):
Chromosome 23 (position 9790070)
Other Location(s):
Assembly Chromosome Position
GRCz10 23 9748211
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
AGTCTGGACATGCAGGGAGAATACAATGGCGGTGGAGTGTGTGTCGAGTG[C/A]CAGGTGGGCTCAGGTGTACAAACATACAATTATKAAGCAATTGKAGTAAT
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa25193
Current Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
We currently estimate that this allele will be available during 2016.
Mutation:
A > C
Consequence:
Essential Splice Site
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000045126 Essential Splice Site 664 3664 16 80
Genomic Location (Zv9):
Chromosome 23 (position 9775068)
Other Location(s):
Assembly Chromosome Position
GRCz10 23 9733209
KASP Assay ID:
554-7863.1 (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
None
Flanking Sequence:
GGAAAGACCTTCTTGAGCAACAGGGGATTAAGTTCAAACCTGTCTGTTTC[A/C]GCATGTGATTGCTCAGTGGAGGGCTCTCGCTCCAGCTCCTGTGATCCAGT
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa18267
Current Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Mutation:
A > C
Consequence:
Essential Splice Site
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000045126 Essential Splice Site 1904 3664 44 80
Genomic Location (Zv9):
Chromosome 23 (position 9727666)
Other Location(s):
Assembly Chromosome Position
GRCz10 23 9685807
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
ACATGCCTCTGTCATAGAGTAAAAGATGTTNNNTGTTTGGTCTTGTTYAC[A/C]GTTTTGCTATTCGCWGTGTGGAGAAGCCCAATAATATGCGGTGCCTGTGY
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa9446
Current Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Mutation:
T > A
Consequence:
Nonsense
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000045126 Nonsense 2164 3664 49 80
Genomic Location (Zv9):
Chromosome 23 (position 9721582)
Other Location(s):
Assembly Chromosome Position
GRCz10 23 9679723
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
AGCTGTGTGATGGTGCTGCTGGAAGATYTGGACAGGATCMGTCATTTTTA[T/A]GAGTCCGTTGCCAATCAGCTGACCAGCCTCAATGCCAGCACCTTCGCCTG
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa43919
Current Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
We currently estimate that this allele will be available during 2016.
Mutation:
T > C
Consequence:
Essential Splice Site
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000045126 Essential Splice Site 2195 3664 49 80
Genomic Location (Zv9):
Chromosome 23 (position 9721487)
Other Location(s):
Assembly Chromosome Position
GRCz10 23 9679628
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
None
Flanking Sequence:
CGCCTGGACTCAACTAAACCGCCTTAATGCCTCCATTGCGGACATTGCTG[T/C]GAGTCTCTTTCTAACATAAACACTATCAGACTTTTGCCGTTAACTTTCAG
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa16193
Current Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Mutation:
A > T
Consequence:
Essential Splice Site
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000045126 Essential Splice Site 2270 3664 52 80
ENSDART00000045126 Essential Splice Site 2270 3664 52 80
Genomic Location (Zv9):
Chromosome 23 (position 9720373)
Other Location(s):
Assembly Chromosome Position
GRCz10 23 9678514
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
ATTTGAAATRYCACAGACAAAGTCAAGTGATGGCATTTGTGCATCTGCTC[A/T]GACATYATACAGCAGGTGAAYCGGACAGCRCAGAATGAGACGCAGGTGAT
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa16078
Current Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Mutation:
A > T
Consequence:
Essential Splice Site
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000045126 Essential Splice Site 2270 3664 52 80
ENSDART00000045126 Essential Splice Site 2270 3664 52 80
Genomic Location (Zv9):
Chromosome 23 (position 9720373)
Other Location(s):
Assembly Chromosome Position
GRCz10 23 9678514
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
ATTTGAAATRYCACAGACAAAGTCAAGTGATGGCATTTGTGCATCTGCTC[A/T]GACATYATACAGCAGGTGAAYCGGACAGCRCAGAATGAGACGCAGGTGAT
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa37625
Current Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
We currently estimate that this allele will be available during 2016.
Mutation:
T > A
Consequence:
Nonsense
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000045126 Nonsense 2433 3664 55 80
Genomic Location (Zv9):
Chromosome 23 (position 9714961)
Other Location(s):
Assembly Chromosome Position
GRCz10 23 9673102
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
None
Flanking Sequence:
CACTGAGCTCACACTCAGACTCGTGCATGCTCTCGTCTCTGTCAGGATTA[T/A]GAGCATCTGGCCGCTCAGCTGGACGGAGCGAGACAGCCCCTAGCTGAAAA
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa18231
Current Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Mutation:
G > A
Consequence:
Essential Splice Site
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000045126 Essential Splice Site 2563 3664 57 80
Genomic Location (Zv9):
Chromosome 23 (position 9711304)
Other Location(s):
Assembly Chromosome Position
GRCz10 23 9669445
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
GAGCACTGAGCTTTTGAAGTCAGCGGAAGAAYTCAACAACAGCAGTCAGA[G/A]TAAGAAGAGCCAACWCTGGATCTGACTGCCTTATTTTGAATGCTATCATG
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa43918
Current Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
We currently estimate that this allele will be available during 2016.
Mutation:
C > T
Consequence:
Nonsense
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000045126 Nonsense 2700 3664 60 80
Genomic Location (Zv9):
Chromosome 23 (position 9708899)
Other Location(s):
Assembly Chromosome Position
GRCz10 23 9667040
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
None
Flanking Sequence:
ACACCACGTTTCAGCCGTCCAACATCTCCGACAGCATCCAGAGGATTCGT[C/T]AACTCATTGAGCAAGCACGCAATGCTGCCAACAAGGTGCCAACTAAGCGT
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa43917
Current Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
We currently estimate that this allele will be available during 2016.
Mutation:
C > T
Consequence:
Nonsense
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000045126 Nonsense 2905 3664 64 80
Genomic Location (Zv9):
Chromosome 23 (position 9699890)
Other Location(s):
Assembly Chromosome Position
GRCz10 23 9658031
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
None
Flanking Sequence:
TGGAGCTGCTCAGTATAAATGAAGAGCTAATCAGCCTCTATAACTTTGAG[C/T]AAACTTTCGACATGAACACCACAACTGATGCACCATGTTCACGGTCAGAG
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa24259
Current Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
We currently estimate that this allele will be available during 2016.
Mutation:
A > T
Consequence:
Nonsense
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000045126 Nonsense 2975 3664 66 80
Genomic Location (Zv9):
Chromosome 23 (position 9697861)
Other Location(s):
Assembly Chromosome Position
GRCz10 23 9656002
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
None
Flanking Sequence:
GATACACGTTATCGTTTATTAATGTCATTTTTTTCTCTGTCTCTTAGGAT[A/T]AATACGTGACCATCGCTGTTCTTGATGGCTTTCTGAGGGTCTTTTATAAC
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa29878
Current Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
We currently estimate that this allele will be available during 2016.
Mutation:
A > G
Consequence:
Essential Splice Site
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000045126 Essential Splice Site 3014 3664 67 80
Genomic Location (Zv9):
Chromosome 23 (position 9697640)
Other Location(s):
Assembly Chromosome Position
GRCz10 23 9655781
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
None
Flanking Sequence:
TTTTAAGTTCAATTGATTTTATGGAATTATTCATTGTGTTTTTTTTTTTC[A/G]GTTGCAAGTCATCCTTCAACTTAACAACATGAAAATGCTTGTGAGGCTGG
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa6725
Current Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
We currently estimate that this allele will be available during 2016.
Mutation:
C > T
Consequence:
Nonsense
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000045126 Nonsense 3019 3664 67 80
Genomic Location (Zv9):
Chromosome 23 (position 9697623)
Other Location(s):
Assembly Chromosome Position
GRCz10 23 9655764
KASP Assay ID:
554-4602.1 (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
TTTATGGAMTTATTCATTGTGTTTTTTTTTTTCAGTTGCAAGTCATCCTT[C/T]AACTTAAYAACATGAAAATGCTTGTGAGGCTGGATCGTGAGACGTTATAT
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa16872
Current Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Mutation:
T > A
Consequence:
Nonsense
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000045126 Nonsense 3100 3664 68 80
Genomic Location (Zv9):
Chromosome 23 (position 9694958)
Other Location(s):
Assembly Chromosome Position
GRCz10 23 9653099
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
AGCTTTGTTCAGATAAAGACCATGAAGAGTTCAGGCATCAGCTTTGGCTG[T/A]CCAGATGACCTGCTGGTGAGAGATTACACTTTNATTCACTTGTGCTGATKC
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa13881
Current Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Mutation:
T > A
Consequence:
Nonsense
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000045126 Nonsense 3200 3664 71 80
Genomic Location (Zv9):
Chromosome 23 (position 9690131)
Other Location(s):
Assembly Chromosome Position
GRCz10 23 9648272
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
TTGTCTKTGAGTTTCTAWACARTTTTGTCTTTGTTTAGGTTGAGCATTTA[T/A]ATAGAYGATGTGCTCGAGAGTTCTGGAGAAACTGGTAATGTAACCACKAG
Associated Phenotype:
Not determined

GWAS

This gene's human homologue has been identified in the following GWAS studies:

  • Colorectal cancer: Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33. (View Study)

(GWAS data comes from http://www.genome.gov/gwastudies/.)

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