chrna4

Ensembl ID:
ENSDARG00000058393
ZFIN ID:
ZDB-GENE-090505-3
Description:
cholinergic receptor, nicotinic, alpha 4 [Source:RefSeq peptide;Acc:NP_001041528]
Human Orthologue:
CHRNA4
Human Description:
cholinergic receptor, nicotinic, alpha 4 [Source:HGNC Symbol;Acc:1958]
Mouse Orthologue:
Chrna4
Mouse Description:
cholinergic receptor, nicotinic, alpha polypeptide 4 Gene [Source:MGI Symbol;Acc:MGI:87888]

Alleles

There are 2 alleles of this gene:

Allele name Consequence Status Availability Estimate
sa31820 Essential Splice Site Mutation detected in F1 DNA During 2016
e47 Nonsense Available for shipment Available now

Mutation Details

Allele Name:
sa31820
Current Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
We currently estimate that this allele will be available during 2016.
Mutation:
T > A
Consequence:
Essential Splice Site
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000104115 Essential Splice Site 85 627 3 6
Genomic Location (Zv9):
Chromosome 11 (position 13219127)
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
None
Flanking Sequence:
CCAGGATGAGAAGAATCAGATGATGACCACAAATGTCTGGGTGAAGCAGG[T/A]ATGTTTTCATCAAAAAAAAAAAAAAAAACGCCCATAATTAGACATTAATG
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
e47
Current Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Mutation:
G > A
Consequence:
Nonsense
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000104115 Nonsense 94 627 4 6
Genomic Location (Zv9):
Chromosome 11 (position 13219300)
Other Location(s):
Assembly Chromosome Position
GRCz10 11 12935908
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
None
Flanking Sequence:
GATGAGCGCACATGTTTCCCTGCAGGAGTGGAACGACTACAAGCTGCGCT[G/A]GAACCCAGAGGAGTATGAGAATGTCACCTCCATCAGGATCCCCTCTGAGA
Associated Phenotype:
Not determined

GWAS

This gene's human homologue has been identified in the following GWAS studies:

(GWAS data comes from http://www.genome.gov/gwastudies/.)

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