si:dkey-194n13.2

Ensembl ID:
ENSDARG00000057273
ZFIN ID:
ZDB-GENE-090311-47
Description:
Novel protein similar to vertebrate arachidonate 5-lipoxygenase (ALOX5) [Source:UniProtKB/TrEMBL;Acc
Human Orthologue:
ALOX5
Human Description:
arachidonate 5-lipoxygenase [Source:HGNC Symbol;Acc:435]
Mouse Orthologue:
Alox5
Mouse Description:
arachidonate 5-lipoxygenase Gene [Source:MGI Symbol;Acc:MGI:87999]

Alleles

There are 7 alleles of this gene:

Allele name Consequence Status Availability Estimate
sa22263 Nonsense Available for shipment Available now
sa12277 Essential Splice Site Available for shipment Available now
sa42170 Nonsense Mutation detected in F1 DNA During 2017
sa1464 Nonsense Available for shipment Available now
sa35451 Nonsense Mutation detected in F1 DNA During 2017
sa17538 Essential Splice Site Available for shipment Available now
sa6291 Nonsense Mutation detected in F1 DNA During 2017

Mutation Details

Allele Name:
sa22263
Current Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Mutation:
C > A
Consequence:
Nonsense
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000079884 Nonsense 53 674 2 14

The following transcripts of ENSDARG00000057273 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 13 (position 18216870)
Other Location(s):
Assembly Chromosome Position
GRCz10 13 18036905
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
None
Flanking Sequence:
GTAAAATTGAATTTTAAAAGCATTTGGCATTTTGTGATTCAAGGTGGACT[C/A]ATATGACATCAGCGTAGGAGAGGATCTTGGTGAAATTCAGCTGGTTAAAA
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa12277
Current Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Order Allele From EZRC
Mutation:
G > A
Consequence:
Essential Splice Site
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000079884 Essential Splice Site 117 674 3 14

The following transcripts of ENSDARG00000057273 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 13 (position 18216598)
Other Location(s):
Assembly Chromosome Position
GRCz10 13 18036633
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
TARTACAGCATTCAATTTTAGTATAACATTTGGATGCTTGTTGKGTTTCA[G/A]CTCGATTGCCACAGCACGACAAGACCGGAGTGGCGAAACAGCACAGGCGC
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa42170
Current Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
We currently estimate that this allele will be available during 2017.
Mutation:
C > T
Consequence:
Nonsense
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000079884 Nonsense 140 674 3 14

The following transcripts of ENSDARG00000057273 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 13 (position 18216529)
Other Location(s):
Assembly Chromosome Position
GRCz10 13 18036564
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
None
Flanking Sequence:
ACAAGACCGGAGTGGCGAAACAGCACAGGCGCAAAGAACTGGAACAGAGA[C/T]AGAAGACATACAGGTTTGATGCAACTTTTAAAATAAGGTCAACCACTGCA
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa1464
Current Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Mutation:
C > A
Consequence:
Nonsense
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000079884 Nonsense 201 674 5 14

The following transcripts of ENSDARG00000057273 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 13 (position 18196746)
Other Location(s):
Assembly Chromosome Position
GRCz10 13 18016781
KASP Assay ID:
554-1389.1 (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
TAGGATCGAGAATCTGTATGTGAACCAGTTCATGCACATGTTCCAGTCCT[C/A]ATGGGGAGATTTCGCAGACTTTGAGCGGATATTTGTGAGAATTAAGAACA
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa35451
Current Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
We currently estimate that this allele will be available during 2017.
Mutation:
T > G
Consequence:
Nonsense
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000079884 Nonsense 235 674 6 14

The following transcripts of ENSDARG00000057273 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 13 (position 18194250)
Other Location(s):
Assembly Chromosome Position
GRCz10 13 18014285
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
None
Flanking Sequence:
TTTTCAGAATATGTGATGGAGCACTGGAAAGAAGACTTCATGTTTGGATA[T/G]CAATACTTAAACGGCTGTAATCCAGTGGTCATCAAAAAATGCACTGAAAT
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa17538
Current Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Order Allele From EZRC
Mutation:
A > G
Consequence:
Essential Splice Site
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000079884 Essential Splice Site 328 674 8 14

The following transcripts of ENSDARG00000057273 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 13 (position 18191124)
Other Location(s):
Assembly Chromosome Position
GRCz10 13 18011159
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
ATAAAATTATTACTGATGAGTTCTGAAAATGATCRTGATTTCTTTTACRT[A/G]GCTGCATCAGWAACCAGGAGAGGACAATCCCATCTTCCTTCCCAGTGACG
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa6291
Current Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
We currently estimate that this allele will be available during 2017.
Mutation:
A > T
Consequence:
Nonsense
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000079884 Nonsense 331 674 8 14

The following transcripts of ENSDARG00000057273 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 13 (position 18191113)
Other Location(s):
Assembly Chromosome Position
GRCz10 13 18011148
KASP Assay ID:
554-5407.1 (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
ACTGATGAGTTCTGAAAATGATCRTGATTTCTTTTACATAGCTGCATCAG[A/T]AACCAGGAGAGGACAATCCCATCTTCCTTCCCAGTGACGATGAGTAYGAC
Associated Phenotype:
Not determined

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