fto

Ensembl ID:
ENSDARG00000044216
ZFIN ID:
ZDB-GENE-061108-1
Description:
Fto protein [Source:UniProtKB/TrEMBL;Acc:Q568I7]
Human Orthologue:
FTO
Human Description:
fat mass and obesity associated [Source:HGNC Symbol;Acc:24678]
Mouse Orthologue:
Fto
Mouse Description:
fat mass and obesity associated Gene [Source:MGI Symbol;Acc:MGI:1347093]

Alleles

There are 3 alleles of this gene:

Allele name Consequence Status Availability Estimate
sa12749 Nonsense Available for shipment Available now
e37 Nonsense Confirmed mutation in F2 line Unknown
sa34123 Nonsense Mutation detected in F1 DNA During 2016

Mutation Details

Allele Name:
sa12749
Current Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Order Allele From EZRC
Mutation:
T > A
Consequence:
Nonsense
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000064913 Nonsense 119 568 3 9
ENSDART00000130028 Nonsense 131 579 3 10
Genomic Location (Zv9):
Chromosome 7 (position 37641209)
Other Location(s):
Assembly Chromosome Position
GRCz10 7 36042810
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
TACACGTACCGTTATCTGGACACTCGTCTGTTCACCATCCCCTGGCACTG[T/A]GAAGGAGAAGAGGGCCAGAAAGATGAGAAAGGCAAACCTTGCTGTGACTC
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
e37
Current Status:
Confirmed mutation in F2 line
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Unknown
Mutation:
T > A
Consequence:
Nonsense
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000064913 Nonsense 372 568 5 9
ENSDART00000130028 Nonsense 384 579 5 10
Genomic Location (Zv9):
Chromosome 7 (position 37629518)
Other Location(s):
Assembly Chromosome Position
GRCz10 7 36031119
KASP Assay ID:
554-0074.1 (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
None
Flanking Sequence:
GGCTGTTGCGTTGTATGCACAGATGATCTGAACCGGACACATCAGCACTG[T/A]GTACTGGCTGGTGACACAGCTAGATTCAGCTCAACTCACAGAGTCGCACA
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa34123
Current Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
We currently estimate that this allele will be available during 2016.
Mutation:
G > A
Consequence:
Nonsense
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000064913 Nonsense 447 568 7 9
ENSDART00000130028 Nonsense 459 579 7 10
Genomic Location (Zv9):
Chromosome 7 (position 37617163)
Other Location(s):
Assembly Chromosome Position
GRCz10 7 36018764
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
None
Flanking Sequence:
TGACCTGTGCTGCTCTTTTAGGTGGAGTTTGAGTGGCTGAGGCAGTACTG[G/A]TTCCAGGGCCGGCGTTACGCTCGATTCTGCAGCTGGTGGACTAAACCCAT
Associated Phenotype:
Not determined

GWAS

This gene's human homologue has been identified in the following GWAS studies:

  • Adiposity: Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile. (View Study)
  • Body mass in chronic obstructive pulmonary disease: Genome-wide association analysis of body mass in chronic obstructive pulmonary disease. (View Study)
  • Body mass index: A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. (View Study)
  • Body mass index: Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. (View Study)
  • Body mass index: Common variants at CDKAL1 and KLF9 are associated with body mass index in east Asian populations. (View Study)
  • Body mass index: Common variants near MC4R are associated with fat mass, weight and risk of obesity. (View Study)
  • Body mass index: FTO genotype is associated with phenotypic variability of body mass index. (View Study)
  • Body mass index: Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. (View Study)
  • Height: A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits. (View Study)
  • Melanoma: A variant in FTO shows association with melanoma risk not due to BMI. (View Study)
  • Menarche (age at onset): Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. (View Study)
  • Metabolic syndrome: Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits. (View Study)
  • Obesity: A genome-wide association study on obesity and obesity-related traits. (View Study)
  • Obesity: Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations. (View Study)
  • Obesity: Replication of 13 obesity loci among Singaporean Chinese, Malay and Asian-Indian populations. (View Study)
  • Obesity (early onset extreme): Genome wide association (GWA) study for early onset extreme obesity supports the role of fat mass and obesity associated gene (FTO) variants. (View Study)
  • Obesity (extreme): Common body mass index-associated variants confer risk of extreme obesity. (View Study)
  • Obesity (extreme): Two new Loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and german study groups. (View Study)
  • Obesity-related traits: Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. (View Study)
  • Osteoarthritis: Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study. (View Study)
  • Testosterone levels: Genome-wide association study of circulating estradiol, testosterone, and sex hormone-binding globulin in postmenopausal women. (View Study)
  • Type 2 diabetes: A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. (View Study)
  • Type 2 diabetes: Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data. (View Study)
  • Type 2 diabetes: Genome-wide association study for type 2 diabetes in Indians identifies a new susceptibility locus at 2q21. (View Study)
  • Type 2 diabetes: Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. (View Study)
  • Type 2 diabetes: Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. (View Study)
  • Type 2 diabetes: Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. (View Study)
  • Type 2 diabetes: Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases. (View Study)
  • Type 2 diabetes: Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. (View Study)
  • Visceral fat: Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (View Study)
  • Waist circumference: NRXN3 is a novel locus for waist circumference: a genome-wide association study from the CHARGE Consortium. (View Study)
  • Weight: Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. (View Study)

(GWAS data comes from http://www.genome.gov/gwastudies/.)

Register

If you would like to be informed when the status of this gene changes (for example, a new allele is generated or an allele is made available for distribution) then please enter your details below:

Short-link