ttk

Ensembl ID:
ENSDARG00000041361
ZFIN ID:
ZDB-GENE-030123-1
Description:
Dual specificity protein kinase Ttk [Source:UniProtKB/Swiss-Prot;Acc:Q8AYG3]
Human Orthologue:
TTK
Human Description:
TTK protein kinase [Source:HGNC Symbol;Acc:12401]
Mouse Orthologue:
Ttk
Mouse Description:
Ttk protein kinase Gene [Source:MGI Symbol;Acc:MGI:1194921]

Alleles

There are 4 alleles of this gene:

Allele name Consequence Status Availability Estimate
sa11341 Essential Splice Site Available for shipment Available now
sa18112 Nonsense Available for shipment Available now
sa42649 Nonsense Mutation detected in F1 DNA During 2016
sa25000 Nonsense Mutation detected in F1 DNA During 2016

Mutation Details

Allele Name:
sa11341
Current Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Mutation:
G > A
Consequence:
Essential Splice Site
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000060630 Essential Splice Site 29 982 2 25
ENSDART00000131876 Essential Splice Site 29 983 2 25
ENSDART00000138654   None 160 None 5
Genomic Location (Zv9):
Chromosome 16 (position 6375630)
Other Location(s):
Assembly Chromosome Position
GRCz10 16 5241924
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
TGCCATGCTGTGTCAAAAGCTGGCCATGATGAAGCAATTGTTCAATGAAG[G/A]TAATCGATTTATTAATTAGTTTNTTTTCAGRATTCCTAATGTAGGATTCCA
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa18112
Current Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Mutation:
C > T
Consequence:
Nonsense
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000060630 Nonsense 587 982 15 25
ENSDART00000131876 Nonsense 588 983 15 25
ENSDART00000138654   None 160 None 5
Genomic Location (Zv9):
Chromosome 16 (position 6358571)
Other Location(s):
Assembly Chromosome Position
GRCz10 16 5224865
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
CACCTCTTCGATTAAACCCCTCACTCAGCTGTCAGACGCCCAACTACAGA[C/T]AGCCAAATCCTAACAGGTGATGAGARCACAGATAAAYATGTGGATTAGAT
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa42649
Current Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
We currently estimate that this allele will be available during 2016.
Mutation:
T > A
Consequence:
Nonsense
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000060630 Nonsense 615 982 16 25
ENSDART00000131876 Nonsense 616 983 16 25
ENSDART00000138654   None 160 None 5
Genomic Location (Zv9):
Chromosome 16 (position 6358000)
Other Location(s):
Assembly Chromosome Position
GRCz10 16 5224294
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
None
Flanking Sequence:
AAGCAGCGGCCTGTGATTGTGTCTGTTCCAGCGACGGCTCAGAAAATGTG[T/A]CCGACTGCGCTGCCCTGCACGCCTCAGAGCGGTGTGTCCTACATCCAGCC
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa25000
Current Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
We currently estimate that this allele will be available during 2016.
Mutation:
C > A
Consequence:
Nonsense
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000060630 Nonsense 961 982 25 25
ENSDART00000131876 Nonsense 962 983 25 25
ENSDART00000138654 Nonsense 139 160 5 5
Genomic Location (Zv9):
Chromosome 16 (position 6344817)
Other Location(s):
Assembly Chromosome Position
GRCz10 16 5211111
KASP Assay ID:
554-7798.1 (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
None
Flanking Sequence:
GACATCGTTAACCTTTAGCCTCTGTCTCTGCAGAATTTAGCCATGATGTG[C/A]AACAGCGGGAGGAAACTGGATGTTTCTGAATGTGTGAAAAGCTCCAGTCA
Associated Phenotype:
Not determined

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