irx6a

Ensembl ID:
ENSDARG00000034420
ZFIN ID:
ZDB-GENE-040712-5
Description:
Iroquois homeobox protein 6aIrx6a protein [Source:UniProtKB/TrEMBL;Acc:Q503Z8]
Human Orthologue:
IRX6
Human Description:
iroquois homeobox 6 [Source:HGNC Symbol;Acc:14675]
Mouse Orthologue:
Irx6
Mouse Description:
Iroquois related homeobox 6 (Drosophila) Gene [Source:MGI Symbol;Acc:MGI:1927642]

Alleles

There are 3 alleles of this gene:

Allele name Consequence Status Availability Estimate
sa21007 Essential Splice Site Available for shipment Available now
sa44671 Nonsense Mutation detected in F1 DNA During 2017
sa1145 Nonsense Available for shipment Available now

Mutation Details

Allele Name:
sa21007
Current Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Mutation:
A > T
Consequence:
Essential Splice Site
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000045628 Essential Splice Site 16 477 2 7
Genomic Location (Zv9):
Chromosome 7 (position 36969797)
Other Location(s):
Assembly Chromosome Position
GRCz10 7 35243640
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
None
Flanking Sequence:
CTTTGAAACGCAAATAAAAAAGTCATGTTTATCCACAATTTTCTTCATGC[A/T]GTTTTTCGTGTCGGCAACCCCCAGTACGACTTGCTGCGATTCGATATCCA
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa44671
Current Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
We currently estimate that this allele will be available during 2017.
Mutation:
G > A
Consequence:
Nonsense
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000045628 Nonsense 214 477 4 7
Genomic Location (Zv9):
Chromosome 7 (position 36968688)
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
None
Flanking Sequence:
CTGGTTTGCCAATGCTAGAAGACGACTAAAAAAAGAAAACAAGATGACTT[G/A]GTCCCCCAAAAACAAAGCAGGCGATGACAGGAAGGAAGACCTCGGTAAGA
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa1145
Current Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Mutation:
A > T
Consequence:
Nonsense
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000045628 Nonsense 225 477 4 7
Genomic Location (Zv9):
Chromosome 7 (position 36968656)
Other Location(s):
Assembly Chromosome Position
GRCz10 7 35242499
KASP Assay ID:
554-1056.1 (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
AAGAAAACAAGATGACTTGGTCCCCCAAAAACAAAGCAGGCGATGACAGG[A/T]AGGAAGACCTCGGTAAGAGTGACCCAGACATTACCAAAGGTACCTCATAA
Associated Phenotype:

Normal

Stage Entity Quality Tag
Larval:Day 5
ZFS:0000037
whole organism
ZFA:0001094
quality
PATO:0000001
normal
PATO:0000461

GWAS

This gene's human homologue has been identified in the following GWAS studies:

  • Visceral fat: Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (View Study)

(GWAS data comes from http://www.genome.gov/gwastudies/.)

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