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Ensembl ID:
ENSDARG00000013598
ZFIN ID:
ZDB-GENE-050601-2
Description:
tumor necrosis factor (TNF superfamily, member 2) [Source:RefSeq peptide;Acc:NP_001019618]
Human Orthologues:
LTA, TNF
Human Descriptions:
lymphotoxin alpha (TNF superfamily, member 1) [Source:HGNC Symbol;Acc:6709]
tumor necrosis factor [Source:HGNC Symbol;Acc:11892]
Mouse Orthologues:
Lta, Tnf
Mouse Descriptions:
lymphotoxin A Gene [Source:MGI Symbol;Acc:MGI:104797]
tumor necrosis factor Gene [Source:MGI Symbol;Acc:MGI:104798]

Alleles

There are 2 alleles of this gene:

Allele name Consequence Status Availability Estimate
sa22693 Essential Splice Site Available for shipment Available now
sa22694 Splice Site, Nonsense Available for shipment Available now

Mutation Details

Allele Name:
sa22693
Current Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Mutation:
G > A
Consequence:
Essential Splice Site
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000017569 Essential Splice Site 60 242 1 4
Genomic Location (Zv9):
Chromosome 15 (position 33996070)
Other Location(s):
Assembly Chromosome Position
GRCz10 15 34841846
KASP Assay ID:
2260-8809.1 (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
None
Flanking Sequence:
TTGTTGGCCTCTGCGTTGTGGCTGCATTTTTCTTCACCTGGCATGTGATG[G/A]TAAGACTGAAATTTCATTGAGGGATGATCATTGGAATAATGAAACATTCT
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa22694
Current Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Mutation:
C > A
Consequence:
Splice Site, Nonsense
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000017569 Splice Site, Nonsense 82 242 2 4
Genomic Location (Zv9):
Chromosome 15 (position 33996221)
Other Location(s):
Assembly Chromosome Position
GRCz10 15 34841997
KASP Assay ID:
2260-8810.1 (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
None
Flanking Sequence:
AGGTCAGAAACCCAACAGAGAACATCTAAAACAACAAATCACCACACCTT[C/A]AGGTTAATAACATTCCCAGTATTCCATCTTGTACTTTTGTTTTGCTTTTC
Associated Phenotype:
Not determined

GWAS

This gene's human homologue has been identified in the following GWAS studies:

  • AIDS progression: Genomewide association study of an AIDS-nonprogression cohort emphasizes the role played by HLA genes (ANRS Genomewide Association Study 02). (View Study)
  • Crohn's disease: Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. (View Study)
  • Neonatal lupus: Identification of candidate loci at 6p21 and 21q22 in a genome-wide association study of cardiac manifestations of neonatal lupus. (View Study)

(GWAS data comes from http://www.genome.gov/gwastudies/.)

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