fen1

Ensembl ID:
ENSDARG00000011404
ZFIN ID:
ZDB-GENE-031112-11
Description:
Fen1 proteinFlap structure-specific endonuclease 1 [Source:UniProtKB/TrEMBL;Acc:Q6TNU4]
Human Orthologue:
FEN1
Human Description:
flap structure-specific endonuclease 1 [Source:HGNC Symbol;Acc:3650]
Mouse Orthologue:
Fen1
Mouse Description:
flap structure specific endonuclease 1 Gene [Source:MGI Symbol;Acc:MGI:102779]

Alleles

There are 4 alleles of this gene:

Allele name Consequence Status Availability Estimate
sa37839 Nonsense Mutation detected in F1 DNA During 2016
sa15638 Essential Splice Site Available for shipment Available now
sa24456 Nonsense Available for shipment Available now
sa32479 Nonsense Available for shipment Available now

Mutation Details

Allele Name:
sa37839
Current Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
We currently estimate that this allele will be available during 2016.
Mutation:
C > T
Consequence:
Nonsense
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000024224 Nonsense 104 380 5 12
Genomic Location (Zv9):
Chromosome 24 (position 11685843)
Other Location(s):
Assembly Chromosome Position
GRCz10 24 11773156
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
None
Flanking Sequence:
TGTGACAATTGCAAACACTTATATTGCAGCTTGAGAAGAGAGTTGAGAGA[C/T]GAGCAGAGGCTGAGAAACTTCTAGCTCAGGCACAAGAAGCAGGTACAGAC
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa15638
Current Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Order Allele From EZRC
Mutation:
T > C
Consequence:
Essential Splice Site
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000024224 Essential Splice Site 118 380 5 12
Genomic Location (Zv9):
Chromosome 24 (position 11685887)
Other Location(s):
Assembly Chromosome Position
GRCz10 24 11773200
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
GAGAGACGAGCAGAGGCTGAGAAACTTCTAGCTCAGGCACAAGAAGCAGG[T/C]ACAGACACCATCAAAAATGTACTTTTTCATAAAAAAAATATAATTTTCTT
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa24456
Current Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Mutation:
C > T
Consequence:
Nonsense
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000024224 Nonsense 214 380 8 12
Genomic Location (Zv9):
Chromosome 24 (position 11686467)
Other Location(s):
Assembly Chromosome Position
GRCz10 24 11773780
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
None
Flanking Sequence:
TTCATTTTAGAAAGCTCCCCATCCAAGAGTTTCACTTCAGTCGTATTCTG[C/T]AGGATATGGAGCTGACGCATCAACAGGTGAGTAATATATCAACATGTCTA
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa32479
Current Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Mutation:
C > T
Consequence:
Nonsense
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000024224 Nonsense 339 380 11 12
Genomic Location (Zv9):
Chromosome 24 (position 11691426)
Other Location(s):
Assembly Chromosome Position
GRCz10 24 11778739
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
None
Flanking Sequence:
GTAACGGCTGTAAGAAGATCACAAAGAGCAGACAAGGCAGCACCCAGGGC[C/T]GACTGGACACATTCTTTACTGTAACCGGATCAATCTCTTCTAAGCGTAAG
Associated Phenotype:
Not determined

GWAS

This gene's human homologue has been identified in the following GWAS studies:

  • Metabolite levels: Genetic variants associated with glycine metabolism and their role in insulin sensitivity and type 2 diabetes. (View Study)
  • Phospholipid levels (plasma): Genetic loci associated with plasma phospholipid n-3 fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium. (View Study)
  • Platelet counts: New gene functions in megakaryopoiesis and platelet formation. (View Study)
  • Stearic acid (18:0) plasma levels: Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. (View Study)

(GWAS data comes from http://www.genome.gov/gwastudies/.)

Register

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