tnfa

Ensembl ID:
ENSDARG00000009511
ZFIN ID:
ZDB-GENE-050317-1
Description:
tumor necrosis factor, alpha [Source:RefSeq peptide;Acc:NP_998024]
Human Orthologues:
LTA, TNF
Human Descriptions:
lymphotoxin alpha (TNF superfamily, member 1) [Source:HGNC Symbol;Acc:6709]
tumor necrosis factor [Source:HGNC Symbol;Acc:11892]
Mouse Orthologues:
Lta, Tnf
Mouse Descriptions:
lymphotoxin A Gene [Source:MGI Symbol;Acc:MGI:104797]
tumor necrosis factor Gene [Source:MGI Symbol;Acc:MGI:104798]

Alleles

There are 3 alleles of this gene:

Allele name Consequence Status Availability Estimate
sa16250 Essential Splice Site Available for shipment Available now
sa3045 Essential Splice Site F2 line generated During 2017
sa43296 Nonsense Mutation detected in F1 DNA During 2017

Mutation Details

Allele Name:
sa16250
Current Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
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Mutation:
G > T
Consequence:
Essential Splice Site
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000025847 Essential Splice Site 68 234 2 4
Genomic Location (Zv9):
Chromosome 19 (position 27505511)
Other Location(s):
Assembly Chromosome Position
GRCz10 19 27435623
KASP Assay ID:
2261-3380.1 (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
AWGKCTCTGTTTCTCTCTCTAGACCCAGGGCAATCAACAAGATGGAAGTG[G/T]WGAGTTTCAAATCTTCTTTGTCAGAGTTAAATCAGGTTATTTTGTTTTTT
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa3045
Current Status:
F2 line generated
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
We currently estimate that this allele will be available during 2017.
Mutation:
T > A
Consequence:
Essential Splice Site
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000025847 Essential Splice Site 69 234 2 4
Genomic Location (Zv9):
Chromosome 19 (position 27505512)
Other Location(s):
Assembly Chromosome Position
GRCz10 19 27435624
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
TGKCTCTGTTTCTCTCTCTAGACCCAGGGCAATCAACAAGATGGAAGTGG[T/A]GAGTTTCAAATCTTCTTTGTCAGAGTTAAATCAGGTTATTTTGTTTTTTG
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa43296
Current Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
We currently estimate that this allele will be available during 2017.
Mutation:
T > A
Consequence:
Nonsense
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000025847 Nonsense 140 234 4 4
Genomic Location (Zv9):
Chromosome 19 (position 27509152)
Other Location(s):
Assembly Chromosome Position
GRCz10 19 27439264
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
None
Flanking Sequence:
GATTATCATTCCCGATGATGGCATTTATTTTGTCTACAGCCAGGTGTCTT[T/A]GCACATCAGCTGCACGTCTGAACTGACTGAGGAACAAGTGCTTATGAGCC
Associated Phenotype:
Not determined

GWAS

This gene's human homologue has been identified in the following GWAS studies:

  • AIDS progression: Genomewide association study of an AIDS-nonprogression cohort emphasizes the role played by HLA genes (ANRS Genomewide Association Study 02). (View Study)
  • Crohn's disease: Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. (View Study)
  • Neonatal lupus: Identification of candidate loci at 6p21 and 21q22 in a genome-wide association study of cardiac manifestations of neonatal lupus. (View Study)

(GWAS data comes from http://www.genome.gov/gwastudies/.)

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