si:ch211-181p13.1

Ensembl ID:
ENSDARG00000004789
ZFIN ID:
ZDB-GENE-050208-608
Description:
Novel protein similar to vertebrate low density lipoprotein-related protein 1B (Deleted in tumors) (
Human Orthologue:
LRP1B
Human Description:
low density lipoprotein receptor-related protein 1B [Source:HGNC Symbol;Acc:6693]
Mouse Orthologue:
Lrp1b
Mouse Description:
low density lipoprotein-related protein 1B (deleted in tumors) Gene [Source:MGI Symbol;Acc:MGI:21511

Alleles

There are 21 alleles of this gene:

Allele name Consequence Status Availability Estimate
sa15111 Nonsense Available for shipment Available now
sa24113 Essential Splice Site Available for shipment Available now
sa24112 Essential Splice Site Available for shipment Available now
sa14370 Essential Splice Site Available for shipment Available now
sa43799 Essential Splice Site Mutation detected in F1 DNA During 2017
sa8556 Nonsense Mutation detected in F1 DNA During 2017
sa24111 Essential Splice Site Available for shipment Available now
sa11357 Nonsense Available for shipment Available now
sa12158 Nonsense Available for shipment Available now
sa3167 Nonsense F2 line generated During 2017
sa32392 Nonsense Available for shipment Available now
sa37467 Essential Splice Site Mutation detected in F1 DNA During 2017
sa43798 Nonsense Mutation detected in F1 DNA During 2017
sa753 Essential Splice Site Available for shipment Available now
sa1481 Nonsense Available for shipment Available now
sa13305 Nonsense Available for shipment Available now
sa10588 Nonsense Available for shipment Available now
sa37466 Essential Splice Site Mutation detected in F1 DNA During 2017
sa17465 Essential Splice Site Available for shipment Available now
sa12543 Nonsense Available for shipment Available now
sa19282 Nonsense Mutation detected in F1 DNA During 2017

Mutation Details

Allele Name:
sa15111
Current Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
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Mutation:
C > A
Consequence:
Nonsense
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000004416 Nonsense 481 4616 9 91
ENSDART00000133385 Nonsense 491 2895 9 54
Genomic Location (Zv9):
Chromosome 22 (position 14816729)
Other Location(s):
Assembly Chromosome Position
GRCz10 22 14647277
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
GTGTGCCGCTGCCGGACCGGTCACGTCCTTGCCAGCGAYGGGAAGTCCTG[C/A]AAAAGTGAGGGTCCCAAAAACAATTTCTCTTTAAAATCTCCTMTTGTAGA
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa24113
Current Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
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Mutation:
T > A
Consequence:
Essential Splice Site
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000004416 Essential Splice Site 622 4616 11 91
ENSDART00000133385 Essential Splice Site 632 2895 11 54
Genomic Location (Zv9):
Chromosome 22 (position 14810947)
Other Location(s):
Assembly Chromosome Position
GRCz10 22 14641495
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
None
Flanking Sequence:
AAGGCAATATGTCTCATCCCAGGGCCATTGTTGTGGATCCTCTAAATGGG[T/A]AAGCCCATGATACCATTCCTGCTTACAGCAGCATTTAAAAGCTTCTTCTG
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa24112
Current Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Mutation:
T > G
Consequence:
Essential Splice Site
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000004416 Essential Splice Site 695 4616 12 91
ENSDART00000133385 Essential Splice Site 705 2895 12 54
Genomic Location (Zv9):
Chromosome 22 (position 14807602)
Other Location(s):
Assembly Chromosome Position
GRCz10 22 14638150
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
None
Flanking Sequence:
CTACTATGACCACATCGAGAAAATCTACCTCAACGGCAGCCACAGAACGG[T/G]TAGTAAATGAGTGAGTCGGTTCTTCACTTCTCAAACATCTCCATTCCTCC
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa14370
Current Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
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Mutation:
T > C
Consequence:
Essential Splice Site
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000004416 Essential Splice Site 957 4616 18 91
ENSDART00000133385 Essential Splice Site 967 2895 18 54
Genomic Location (Zv9):
Chromosome 22 (position 14774501)
Other Location(s):
Assembly Chromosome Position
GRCz10 22 14605049
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
GGCTGTACTAATGGGAAATGCATCAGTGTGAAATGGCACTGYGATTCCRG[T/C]AAGCTAATGTTACRAAAGAACTTTTCAGACTTTWTCTGCTCCTTGATCTT
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa43799
Current Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
We currently estimate that this allele will be available during 2017.
Mutation:
T > A
Consequence:
Essential Splice Site
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000004416 Essential Splice Site 1411 4616 25 91
ENSDART00000133385 Essential Splice Site 1421 2895 25 54
Genomic Location (Zv9):
Chromosome 22 (position 14751545)
Other Location(s):
Assembly Chromosome Position
GRCz10 22 14582093
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
None
Flanking Sequence:
GACTCACCTTGGACCACATGGAGAGCAGGATAATCTGGACGGATGCCCGG[T/A]AAGAAAGATGCAAGGCTTCTGTTGGGTTTGTGTCAATATTTCATGATTTG
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa8556
Current Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
We currently estimate that this allele will be available during 2017.
Mutation:
C > A
Consequence:
Nonsense
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000004416 Nonsense 1416 4616 26 91
ENSDART00000133385 Nonsense 1426 2895 26 54
Genomic Location (Zv9):
Chromosome 22 (position 14748597)
Other Location(s):
Assembly Chromosome Position
GRCz10 22 14579145
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
GCTGAGTATGAATGTTTTTTTTNCTTCTCTCCTTAGATCTGAYGCTATATA[C/A]TCTGCTCTATATGAYGGCACGGGGGTGATTGAGATTCTCAGAGGCCACGA
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa24111
Current Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Mutation:
G > T
Consequence:
Essential Splice Site
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000004416 Essential Splice Site 1752 4616 31 91
ENSDART00000133385 Essential Splice Site 1762 2895 31 54
Genomic Location (Zv9):
Chromosome 22 (position 14724762)
Other Location(s):
Assembly Chromosome Position
GRCz10 22 14555310
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
None
Flanking Sequence:
TGACAGCATGAAAAGCCAGCTCCGGAAAGCCACAGCATTAGCAGTGATGG[G/T]TGAGTGAAGGCTGTTTTCATCACCATTCATTGACTAAGGTTAATTATAAC
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa11357
Current Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
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Mutation:
C > T
Consequence:
Nonsense
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000004416 Nonsense 2199 4616 40 91
ENSDART00000133385 Nonsense 2209 2895 40 54
Genomic Location (Zv9):
Chromosome 22 (position 14701391)
Other Location(s):
Assembly Chromosome Position
GRCz10 22 14531939
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
AGAACCCAGTTTATTTTAAAAACATCATCGCTTTGGCCTTTGATCATCGA[C/T]AGRACGCACATGGAACTAATCGGATTTTCTTTAGCGACGTTCACTATGGG
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa12158
Current Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
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Mutation:
T > A
Consequence:
Nonsense
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000004416 Nonsense 2526 4616 46 91
ENSDART00000133385 Nonsense 2536 2895 46 54
Genomic Location (Zv9):
Chromosome 22 (position 14656320)
Other Location(s):
Assembly Chromosome Position
GRCz10 22 14486868
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
TTTKTNCATTCCAGAAAACCGGAACWGCAGACACGGCTTTAAATCTTGTTA[T/A]AACCAACGCTGTGTGTCCAACCAACGCTTCTGTAATGGTGTGAATGATTG
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa3167
Current Status:
F2 line generated
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
We currently estimate that this allele will be available during 2017.
Mutation:
C > T
Consequence:
Nonsense
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000004416 Nonsense 2578 4616 47 91
ENSDART00000133385   2583 2895 47 54
Genomic Location (Zv9):
Chromosome 22 (position 14653090)
Other Location(s):
Assembly Chromosome Position
GRCz10 22 14483638
KASP Assay ID:
554-2797.1 (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
AGCACCGCTGTGCCGATGGCTCCTGTATTCCCACATCATCCTGGTGTAAT[C/T]AGATCATCGATTGCGCTGACGCATCGGACGAGAAGAGCTGTAGTAAGATT
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa32392
Current Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Mutation:
A > T
Consequence:
Nonsense
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000004416 Nonsense 2704 4616 50 91
ENSDART00000133385 Nonsense 2681 2895 50 54
Genomic Location (Zv9):
Chromosome 22 (position 14640829)
Other Location(s):
Assembly Chromosome Position
GRCz10 22 14471377
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
None
Flanking Sequence:
CGTCGTGTCTCTGGAATCAGTTCGCCTGCTCCAAGAACAAGTGCATCTCC[A/T]AACAATGGCTGTGTGACGGTGAAGACGACTGCGGCGACGGACTGGACGAA
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa37467
Current Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
We currently estimate that this allele will be available during 2017.
Mutation:
G > T
Consequence:
Essential Splice Site
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000004416 Essential Splice Site 2769 4616 52 91
ENSDART00000133385 Essential Splice Site 2745 2895 52 54
Genomic Location (Zv9):
Chromosome 22 (position 14631517)
Other Location(s):
Assembly Chromosome Position
GRCz10 22 14462065
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
None
Flanking Sequence:
CTGACACACATAACTAACTACGTGCTTCTTCCTTTTCCTGTCTTTAATAA[G/T]CTCCCAACAACACGTGTACCGACAGCACGTTTCAGTGCCGAAACCAGAAC
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa43798
Current Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
We currently estimate that this allele will be available during 2017.
Mutation:
G > T
Consequence:
Nonsense
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000004416 Nonsense 2816 4616 53 91
ENSDART00000133385 Nonsense 2792 2895 53 54
Genomic Location (Zv9):
Chromosome 22 (position 14629677)
Other Location(s):
Assembly Chromosome Position
GRCz10 22 14460225
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
None
Flanking Sequence:
CATTACCTCTTTCATCCTCTCTTTTCTCTCCAGAGTACCGTTTATGCAAA[G/T]AGGAGGAGTTTCGCTGCGCAGATGGGCGGTGTTTGCTGAGAGCCCAATGG
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa753
Current Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
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Mutation:
T > C
Consequence:
Essential Splice Site
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000004416 Essential Splice Site 3178 4616 59 91
ENSDART00000133385   None 2895 None 54

The following genes are also affected by this mutation:

Genomic Location (Zv9):
Chromosome 22 (position 14604112)
Other Location(s):
Assembly Chromosome Position
GRCz10 22 14435019
KASP Assay ID:
554-0660.1 (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
GAGAACCATATCTTATTTGCAAATATAGACGGTACCAAAAGACACAAAGG[T/C]AAGTGCTTTCTTATCTCAAATCTAAGTCTTGATTAAAATTGACATTAACA
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa1481
Current Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
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Mutation:
T > G
Consequence:
Nonsense
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000004416 Nonsense 3363 4616 64 91
ENSDART00000133385   None 2895 None 54

The following genes are also affected by this mutation:

Genomic Location (Zv9):
Chromosome 22 (position 14598984)
Other Location(s):
Assembly Chromosome Position
GRCz10 22 14429891
KASP Assay ID:
554-1406.1 (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
TGATATATAGTGCAGTGATGTCCTTGTTTGCATTTGCTTTCAGACTCATA[T/G]ATCTGCCTGTCGGGTCAGTTTAAGTGCACACACCGGCAGAAGTGCATCCC
Associated Phenotype:

Normal

Stage Entity Quality Tag
Larval:Day 5
ZFS:0000037
whole organism
ZFA:0001094
quality
PATO:0000001
normal
PATO:0000461

Mutation Details

Allele Name:
sa13305
Current Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
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Mutation:
C > A
Consequence:
Nonsense
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000004416 Nonsense 3595 4616 69 91
ENSDART00000133385   None 2895 None 54

The following genes are also affected by this mutation:

Genomic Location (Zv9):
Chromosome 22 (position 14566981)
Other Location(s):
Assembly Chromosome Position
GRCz10 22 14397888
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
GGAGGAGGCTGTGTTTTGGCTGCTCAGCGCTGCGATGGACAGAACGACTG[C/A]GCAGATGGGTCAGATGAGGTCAGTTYAGTTCATAMACACTGAAWAATACM
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa10588
Current Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
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Mutation:
C > T
Consequence:
Nonsense
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000004416 Nonsense 3815 4616 74 91
ENSDART00000133385   None 2895 None 54

The following genes are also affected by this mutation:

Genomic Location (Zv9):
Chromosome 22 (position 14552620)
Other Location(s):
Assembly Chromosome Position
GRCz10 22 14383527
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
CCTCCGTCTGCCAGTGCAAAGAAGGCTTTCAGAGGAACCAKAAGAACAGG[C/T]AATGTGAAGGTGGGAAACTGTATATTACTGCAATATAAAGTTGCACTCAT
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa37466
Current Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
We currently estimate that this allele will be available during 2017.
Mutation:
G > A
Consequence:
Essential Splice Site
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000004416 Essential Splice Site 4048 4616 78 91
ENSDART00000133385   None 2895 None 54

The following genes are also affected by this mutation:

Genomic Location (Zv9):
Chromosome 22 (position 14546528)
Other Location(s):
Assembly Chromosome Position
GRCz10 22 14377435
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
None
Flanking Sequence:
CGGGTCGATGCGTCGTGTTTTGATCACAAGGAATTTGCGGAGACCGACAG[G/A]TGAAGATGTGACACTCCACTGTGTTTTTCTGACATAAAATATGTAACTAG
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa17465
Current Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
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Mutation:
A > T
Consequence:
Essential Splice Site
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000004416 Essential Splice Site 4088 4616 None 91
ENSDART00000133385   None 2895 None 54

The following genes are also affected by this mutation:

Genomic Location (Zv9):
Chromosome 22 (position 14543229)
Other Location(s):
Assembly Chromosome Position
GRCz10 22 14374136
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
GCRAATGAACGACGGAAAMAGTTTAGTCTGGGTCTGGTTTGCTTTCTTTC[A/T]GGCATCTCTCAGCCCTTCCGYATCGACCTGTTTGAGGACTACATYTACGG
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa12543
Current Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
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Mutation:
C > T
Consequence:
Nonsense
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000004416 Nonsense 4206 4616 82 91
ENSDART00000133385   None 2895 None 54
ENSDART00000004416 Nonsense 4206 4616 82 91
ENSDART00000133385   None 2895 None 54

The following genes are also affected by this mutation:

Genomic Location (Zv9):
Chromosome 22 (position 14534644)
Other Location(s):
Assembly Chromosome Position
GRCz10 22 14365551
KASP Assay ID:
2261-6565.1 (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
ATCTGTGTCGTCCTGCCTGTGAGAMTGGAGGTCGRTGTATCACTAATGAA[C/T]GAGGGGAATCCCGCTGTTTTTGTTGGCCAAATTACTCTGGTGAACGCTGT
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa19282
Current Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
We currently estimate that this allele will be available during 2017.
Mutation:
C > T
Consequence:
Nonsense
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000004416 Nonsense 4206 4616 82 91
ENSDART00000133385   None 2895 None 54
ENSDART00000004416 Nonsense 4206 4616 82 91
ENSDART00000133385   None 2895 None 54

The following genes are also affected by this mutation:

Genomic Location (Zv9):
Chromosome 22 (position 14534644)
Other Location(s):
Assembly Chromosome Position
GRCz10 22 14365551
KASP Assay ID:
2261-6565.1 (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
None
Flanking Sequence:
ATCTGTGTCGTCCTGCCTGTGAGAATGGAGGTCGGTGTATCACTAATGAA[C/T]GAGGGGAATCCCGCTGTTTTTGTTGGCCAAATTACTCTGGTGAACGCTGT
Associated Phenotype:
Not determined

GWAS

This gene's human homologue has been identified in the following GWAS studies:

(GWAS data comes from http://www.genome.gov/gwastudies/.)

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