nalcn

Ensembl ID:
ENSDARG00000001835
ZFIN ID:
ZDB-GENE-050410-12
Description:
sodium leak channel non-selective protein [Source:RefSeq peptide;Acc:NP_001017549]
Human Orthologues:
CACNA1B, NALCN
Human Descriptions:
calcium channel, voltage-dependent, N type, alpha 1B subunit [Source:HGNC Symbol;Acc:1389]
sodium leak channel, non-selective [Source:HGNC Symbol;Acc:19082]
Mouse Orthologue:
Nalcn
Mouse Description:
sodium leak channel, non-selective Gene [Source:MGI Symbol;Acc:MGI:2444306]

Alleles

There are 6 alleles of this gene:

Allele name Consequence Status Availability Estimate
sa30919 Nonsense Mutation detected in F1 DNA During 2017
sa41452 Nonsense Mutation detected in F1 DNA During 2017
sa21514 Essential Splice Site Available for shipment Available now
sa11942 Essential Splice Site Available for shipment Available now
sa18947 Essential Splice Site Mutation detected in F1 DNA During 2017
sa6116 Nonsense Mutation detected in F1 DNA During 2017

Mutation Details

Allele Name:
sa30919
Current Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
We currently estimate that this allele will be available during 2017.
Mutation:
T > A
Consequence:
Nonsense
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000048469 Nonsense 10 1742 1 44
ENSDART00000060066   None 384 3 14
ENSDART00000135022   None 1717 None 43
ENSDART00000142289   None 168 None 4
ENSDART00000145204 Nonsense 10 409 3 13
Genomic Location (Zv9):
Chromosome 9 (position 32775660)
Other Location(s):
Assembly Chromosome Position
GRCz10 9 31931606
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
None
Flanking Sequence:
AGGGTATGCCTGATCGCATGTTATGTGCAGTGCTGGAGCAATTTCAGCTT[T/A]ACTTTTCCCGTTGGTATGTGCGCTTTGTTTCAGTGAGTGTGTGATATCCA
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa41452
Current Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
We currently estimate that this allele will be available during 2017.
Mutation:
T > A
Consequence:
Nonsense
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000048469 Nonsense 627 1742 15 44
ENSDART00000060066   None 384 None 14
ENSDART00000135022 Nonsense 602 1717 14 43
ENSDART00000142289   None 168 None 4
ENSDART00000145204   None 409 None 13
Genomic Location (Zv9):
Chromosome 9 (position 32704240)
Other Location(s):
Assembly Chromosome Position
GRCz10 9 31860186
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
None
Flanking Sequence:
CTAGATCCTTCTGAGTCTTTTTGTTGCTGTTATTTTGGACAATCTTGAGT[T/A]GGATGAAGACCTGAAAAAGTTAAAACAGGTAAGTCATTATTCTTTTTATT
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa21514
Current Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Order Allele From EZRC
Mutation:
A > T
Consequence:
Essential Splice Site
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000048469 Essential Splice Site 730 1742 18 44
ENSDART00000060066   None 384 None 14
ENSDART00000135022 Essential Splice Site 705 1717 17 43
ENSDART00000142289   None 168 None 4
ENSDART00000145204   None 409 None 13
Genomic Location (Zv9):
Chromosome 9 (position 32665969)
Other Location(s):
Assembly Chromosome Position
GRCz10 9 31821915
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
None
Flanking Sequence:
TGATCTGTGCATTGATCTGTGTACATATCTGTAAACCTCTTCTTCTTCCC[A/T]GCTACGAAAGTCAGTATTTAGCATCCGGGCTCGCAACCTAATGGAAAAGG
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa11942
Current Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Order Allele From EZRC
Mutation:
G > A
Consequence:
Essential Splice Site
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000048469 Essential Splice Site 1558 1742 40 44
ENSDART00000060066   None 384 None 14
ENSDART00000135022 Essential Splice Site 1533 1717 39 43
ENSDART00000142289 Essential Splice Site 41 168 1 4
ENSDART00000145204   None 409 None 13
ENSDART00000048469 Essential Splice Site 1558 1742 40 44
ENSDART00000060066   None 384 None 14
ENSDART00000135022 Essential Splice Site 1533 1717 39 43
ENSDART00000142289 Essential Splice Site 41 168 1 4
ENSDART00000145204   None 409 None 13
Genomic Location (Zv9):
Chromosome 9 (position 32629202)
Other Location(s):
Assembly Chromosome Position
GRCz10 9 31785148
KASP Assay ID:
2260-2007.1 (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
ATGGAGCGTCTGCACAATGGAGGAGACGTCAYCTTTCATGATGTACTGAG[G/A]TTAGAAAAGAAAAAGCCTGCTATTAATTCTAGCACATAATTTTACCTTTA
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa18947
Current Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
We currently estimate that this allele will be available during 2017.
Mutation:
G > A
Consequence:
Essential Splice Site
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000048469 Essential Splice Site 1558 1742 40 44
ENSDART00000060066   None 384 None 14
ENSDART00000135022 Essential Splice Site 1533 1717 39 43
ENSDART00000142289 Essential Splice Site 41 168 1 4
ENSDART00000145204   None 409 None 13
ENSDART00000048469 Essential Splice Site 1558 1742 40 44
ENSDART00000060066   None 384 None 14
ENSDART00000135022 Essential Splice Site 1533 1717 39 43
ENSDART00000142289 Essential Splice Site 41 168 1 4
ENSDART00000145204   None 409 None 13
Genomic Location (Zv9):
Chromosome 9 (position 32629202)
Other Location(s):
Assembly Chromosome Position
GRCz10 9 31785148
KASP Assay ID:
2260-2007.1 (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
None
Flanking Sequence:
ATGGAGCGTCTGCACAATGGAGGAGACGTCACCTTTCATGATGTACTGAG[G/A]TTAGAAAAGAAAAAGCCTGCTATTAATTCTAGCACATAATTTTACCTTTA
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa6116
Current Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
We currently estimate that this allele will be available during 2017.
Mutation:
C > T
Consequence:
Nonsense
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000048469 Nonsense 1683 1742 43 44
ENSDART00000060066   None 384 None 14
ENSDART00000135022 Nonsense 1658 1717 42 43
ENSDART00000142289 Nonsense 167 168 4 4
ENSDART00000145204   None 409 None 13
Genomic Location (Zv9):
Chromosome 9 (position 32625545)
Other Location(s):
Assembly Chromosome Position
GRCz10 9 31781491
KASP Assay ID:
554-3849.1 (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
TGAGCCCCACTCTGTCAGACCGCAGTGGATACAGACAGGACTCTGCTGAC[C/T]GACCCCAGAGGAAGCTGGGACAGTGGAGACTTCCTGCAGGTCTAAAGCTT
Associated Phenotype:
Not determined

GWAS

This gene's human homologue has been identified in the following GWAS studies:

(GWAS data comes from http://www.genome.gov/gwastudies/.)

Register

If you would like to be informed when the status of this gene changes (for example, a new allele is generated or an allele is made available for distribution) then please enter your details below:

Short-link