Dr Ultan McDermott

Ultan is a Career Development Fellow (CDF) Group Leader in the Cancer Genome Project and a practising medical oncologist at Addenbrooke's Hospital in Cambridge. He joined the Institute in 2009 to work with Mike Stratton, Andy Futreal and Peter Campbell and establish a high-throughput screen of human cancer cell lines with pre-clinical and clinical compounds.

Ultan qualified in medicine - with distinctions in Medicine and Surgery - in 1994, trained as a medical oncologist and obtained a PhD in cancer biology at Queen's University, Belfast. He was accepted for a post-doctoral research position in Jeff Settleman's lab at Harvard Medical School/Massachusetts General Hospital in 2005.

In Jeff's lab Ultan helped establish a high-throughput platform to screen cancer cell lines with pre-clinical and clinical compounds in order to detect genetic characteristics that could be used in the clinic to stratify patients for treatment. Subsequent publications confirmed the power of this approach in identifying the biological dependence of certain cancer subsets on specific genomic alterations. Ultan's research interests are in the area of predictive biomarkers to cancer therapeutics and in vitro models of drug resistance in human cancers.

Ultan joined the Sanger Institute in 2009 as a clinical research fellow and was appointed to the faculty as a CDF Group Leader in 2010 with the award of a Cancer Research UK Clinician Scientist Fellowship. He is a Fellow of the Royal College of Physicians.

Selected Publications

  • Mobile DNA in cancer. Extensive transduction of nonrepetitive DNA mediated by L1 retrotransposition in cancer genomes.

    Tubio JM, Li Y, Ju YS, Martincorena I, Cooke SL, Tojo M, Gundem G, Pipinikas CP, Zamora J, Raine K, Menzies A, Roman-Garcia P, Fullam A, Gerstung M, Shlien A, Tarpey PS, Papaemmanuil E, Knappskog S, Van Loo P, Ramakrishna M, Davies HR, Marshall J, Wedge DC, Teague JW, Butler AP, Nik-Zainal S, Alexandrov L, Behjati S, Yates LR, Bolli N, Mudie L, Hardy C, Martin S, McLaren S, O'Meara S, Anderson E, Maddison M, Gamble S, ICGC Breast Cancer Group, ICGC Bone Cancer Group, ICGC Prostate Cancer Group, Foster C, Warren AY, Whitaker H, Brewer D, Eeles R, Cooper C, Neal D, Lynch AG, Visakorpi T, Isaacs WB, van't Veer L, Caldas C, Desmedt C, Sotiriou C, Aparicio S, Foekens JA, Eyfjörd JE, Lakhani SR, Thomas G, Myklebost O, Span PN, Børresen-Dale AL, Richardson AL, Van de Vijver M, Vincent-Salomon A, Van den Eynden GG, Flanagan AM, Futreal PA, Janes SM, Bova GS, Stratton MR, McDermott U and Campbell PJ

    Science (New York, N.Y.) 2014;345;6196;1251343

  • Inactivating CUX1 mutations promote tumorigenesis.

    Wong CC, Martincorena I, Rust AG, Rashid M, Alifrangis C, Alexandrov LB, Tiffen JC, Kober C, Chronic Myeloid Disorders Working Group of the International Cancer Genome Consortium, Green AR, Massie CE, Nangalia J, Lempidaki S, Döhner H, Döhner K, Bray SJ, McDermott U, Papaemmanuil E, Campbell PJ and Adams DJ

    Nature genetics 2014;46;1;33-8

  • Processed pseudogenes acquired somatically during cancer development.

    Cooke SL, Shlien A, Marshall J, Pipinikas CP, Martincorena I, Tubio JM, Li Y, Menzies A, Mudie L, Ramakrishna M, Yates L, Davies H, Bolli N, Bignell GR, Tarpey PS, Behjati S, Nik-Zainal S, Papaemmanuil E, Teixeira VH, Raine K, O'Meara S, Dodoran MS, Teague JW, Butler AP, Iacobuzio-Donahue C, Santarius T, Grundy RG, Malkin D, Greaves M, Munshi N, Flanagan AM, Bowtell D, Martin S, Larsimont D, Reis-Filho JS, Boussioutas A, Taylor JA, Hayes ND, Janes SM, Futreal PA, Stratton MR, McDermott U, Campbell PJ and ICGC Breast Cancer Group

    Nature communications 2014;5;3644

  • A genetic progression model of Braf(V600E)-induced intestinal tumorigenesis reveals targets for therapeutic intervention.

    Rad R, Cadiñanos J, Rad L, Varela I, Strong A, Kriegl L, Constantino-Casas F, Eser S, Hieber M, Seidler B, Price S, Fraga MF, Calvanese V, Hoffman G, Ponstingl H, Schneider G, Yusa K, Grove C, Schmid RM, Wang W, Vassiliou G, Kirchner T, McDermott U, Liu P, Saur D and Bradley A

    Cancer cell 2013;24;1;15-29

  • MED12 controls the response to multiple cancer drugs through regulation of TGF-β receptor signaling.

    Huang S, Hölzel M, Knijnenburg T, Schlicker A, Roepman P, McDermott U, Garnett M, Grernrum W, Sun C, Prahallad A, Groenendijk FH, Mittempergher L, Nijkamp W, Neefjes J, Salazar R, Ten Dijke P, Uramoto H, Tanaka F, Beijersbergen RL, Wessels LF and Bernards R

    Cell 2012;151;5;937-50

  • Systematic identification of genomic markers of drug sensitivity in cancer cells.

    Garnett MJ, Edelman EJ, Heidorn SJ, Greenman CD, Dastur A, Lau KW, Greninger P, Thompson IR, Luo X, Soares J, Liu Q, Iorio F, Surdez D, Chen L, Milano RJ, Bignell GR, Tam AT, Davies H, Stevenson JA, Barthorpe S, Lutz SR, Kogera F, Lawrence K, McLaren-Douglas A, Mitropoulos X, Mironenko T, Thi H, Richardson L, Zhou W, Jewitt F, Zhang T, O'Brien P, Boisvert JL, Price S, Hur W, Yang W, Deng X, Butler A, Choi HG, Chang JW, Baselga J, Stamenkovic I, Engelman JA, Sharma SV, Delattre O, Saez-Rodriguez J, Gray NS, Settleman J, Futreal PA, Haber DA, Stratton MR, Ramaswamy S, McDermott U and Benes CH

    Nature 2012;483;7391;570-5

  • A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations.

    Sharma SV, Lee DY, Li B, Quinlan MP, Takahashi F, Maheswaran S, McDermott U, Azizian N, Zou L, Fischbach MA, Wong KK, Brandstetter K, Wittner B, Ramaswamy S, Classon M and Settleman J

    Cell 2010;141;1;69-80

  • Acquired resistance of non-small cell lung cancer cells to MET kinase inhibition is mediated by a switch to epidermal growth factor receptor dependency.

    McDermott U, Pusapati RV, Christensen JG, Gray NS and Settleman J

    Cancer research 2010;70;4;1625-34

  • Personalized cancer therapy with selective kinase inhibitors: an emerging paradigm in medical oncology.

    McDermott U and Settleman J

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2009;27;33;5650-9

  • Genomic alterations of anaplastic lymphoma kinase may sensitize tumors to anaplastic lymphoma kinase inhibitors.

    McDermott U, Iafrate AJ, Gray NS, Shioda T, Classon M, Maheswaran S, Zhou W, Choi HG, Smith SL, Dowell L, Ulkus LE, Kuhlmann G, Greninger P, Christensen JG, Haber DA and Settleman J

    Cancer research 2008;68;9;3389-95

  • Identification of genotype-correlated sensitivity to selective kinase inhibitors by using high-throughput tumor cell line profiling.

    McDermott U, Sharma SV, Dowell L, Greninger P, Montagut C, Lamb J, Archibald H, Raudales R, Tam A, Lee D, Rothenberg SM, Supko JG, Sordella R, Ulkus LE, Iafrate AJ, Maheswaran S, Njauw CN, Tsao H, Drew L, Hanke JH, Ma XJ, Erlander MG, Gray NS, Haber DA and Settleman J

    Proceedings of the National Academy of Sciences of the United States of America 2007;104;50;19936-41

[Wellcome Library, London]

Ultan's Project
Cancer genome project
Research Area
Human genetics
Email
um1@sanger.ac.uk
* quick link - http://q.sanger.ac.uk/5goix5h8