Dr Sarah Teichmann

Sarah's research uses genomic approaches to study global regulation of gene expression in the mouse immune system.

Sarah Teichmann has a background in bioinformatics, and a long-standing interest in structural bioinformatics and global regulation of gene expression. She started working on T-cell differentiation, a model to study phenotypic switches in cell state, while a group leader at the MRC (Medical Research Council) Laboratory of Molecular Biology.

Sarah graduated from Trinity College, Cambridge in 1996 with a degree in Natural Science Tripos/Biochemistry. She joined Cyrus Chothia's group at the MRC Laboratory of Molecular Biology to study for a PhD in Computational Genomics, exploring the protein families and domain organisation of proteins in the first completely sequenced genomes. For this work, she was awarded the Max Perutz Prize and a Trinity College Junior Research Fellowship.

In 2000, Sarah went to Janet Thornton's group at University College London as a Beit Memorial Fellow and studied evolution of systems: metabolic pathways and protein interaction networks. From 2001-2012, she was an MRC Programme Leader, initially studying patterns in protein interactions and transcriptional regulatory networks with a purely computational group. Later, in 2010, the programme expanded to deciphering mouse T helper cell differentiation by integrating laboratory-based systems biology, supported by an ERC Grant.

In 2013 Sarah took up a joint position between the Sanger Institute and the EMBL-European Bioinformatics Institute, and her Sanger Institute group is planning to develop high-throughput single-cell genomics approaches to profile cell populations and their dynamics in the immune system.

Sarah is also a teaching fellow and Director of Studies at Trinity College, Cambridge, since 2005, and a Principal Research Associate at the Cavendish Laboratory (Physics Department, University of Cambridge) from 2013.

Sarah's work has been recognized by numerous awards and prizes, including the Colworth Medal (Biochemical Society, 2010), Lister Research Prize (2010), Crick Lecture (Royal Society, 2012) and EMBO membership (2012).

Selected Publications

  • DNA sequence preferences of transcriptional activators correlate more strongly than repressors with nucleosomes.

    Charoensawan V, Janga SC, Bulyk ML, Babu MM and Teichmann SA

    Molecular cell 2012;47;2;183-92

  • EpiChIP: gene-by-gene quantification of epigenetic modification levels.

    Hebenstreit D, Gu M, Haider S, Turner DJ, Liò P and Teichmann SA

    Nucleic acids research 2011;39;5;e27

  • RNA sequencing reveals two major classes of gene expression levels in metazoan cells.

    Hebenstreit D, Fang M, Gu M, Charoensawan V, van Oudenaarden A and Teichmann SA

    Molecular systems biology 2011;7;497

  • The impact of gene expression regulation on evolution of extracellular signaling pathways.

    Charoensawan V, Adryan B, Martin S, Söllner C, Thisse B, Thisse C, Wright GJ and Teichmann SA

    Molecular & cellular proteomics : MCP 2010;9;12;2666-77

  • Assembly reflects evolution of protein complexes.

    Levy ED, Boeri Erba E, Robinson CV and Teichmann SA

    Nature 2008;453;7199;1262-5

  • DBD--taxonomically broad transcription factor predictions: new content and functionality.

    Wilson D, Charoensawan V, Kummerfeld SK and Teichmann SA

    Nucleic acids research 2008;36;Database issue;D88-92

  • Gene regulatory network growth by duplication.

    Teichmann SA and Babu MM

    Nature genetics 2004;36;5;492-6

  • Domain combinations in archaeal, eubacterial and eukaryotic proteomes.

    Apic G, Gough J and Teichmann SA

    Journal of molecular biology 2001;310;2;311-25

  • Advances in structural genomics.

    Teichmann SA, Chothia C and Gerstein M

    Current opinion in structural biology 1999;9;3;390-9

  • Structural assignments to the Mycoplasma genitalium proteins show extensive gene duplications and domain rearrangements.

    Teichmann SA, Park J and Chothia C

    Proceedings of the National Academy of Sciences of the United States of America 1998;95;25;14658-63

* quick link - http://q.sanger.ac.uk/aumrxcf4