Honorary Faculty - Samuli Ripatti

Dr Samuli Ripatti's research focuses on genetic variation and its relation to human metabolism and cardiovascular diseases. He works closely with the Sanger Institute's Human Genetics Faculty to apply genome-wide analysis to the data from Finnish cohorts. This population has a long tradition of biobanking and registry-based follow-up for clinical events that provides a strong basis for collaborative research.

Samuli graduated from Helsinki University with a MSc in statistics. His doctorate project focused on statistical modelling of correlated data and he received his PhD degree in mathematical statistics from Stockholm University. After post doctorate periods at Karolinska Institute in Stockholm and National Public Health Institute in Helsinki he was appointed to a group leader position at FIMM (Institute for Molecular Medicine Finland).

Samuli's group studies genetic variation and its connection to lipids, metabolites and other risk factors for metabolic diseases. The group also builds statistical and computational models for cardiovascular disease risk estimation.

Selected Publications

• Detailed metabolic and genetic characterization reveals new associations for 30 known lipid loci.

  Tukiainen T, Kettunen J, Kangas AJ, Lyytikäinen LP, Soininen P, Sarin AP, Tikkanen E, O'Reilly PF, Savolainen MJ, Kaski K, Pouta A, Jula A, Lehtimäki T, Kähönen M, Viikari J, Taskinen MR, Jauhiainen M, Eriksson JG, Raitakari O, Salomaa V, Järvelin MR, Perola M, Palotie A, Ala-Korpela M and Ripatti S

  Human molecular genetics 2012;21;6;1444-55

  PUBMED: 22156771; DOI: 10.1093/hmg/ddr581

• Genome-wide association study identifies multiple loci influencing human serum metabolite levels.

  Kettunen J, Tukiainen T, Sarin AP, Ortega-Alonso A, Tikkanen E, Lyytikäinen LP, Kangas AJ, Soininen P, Würtz P, Silander K, Dick DM, Rose RJ, Savolainen MJ, Viikari J, Kähönen M, Lehtimäki T, Pietiläinen KH, Inouye M, McCarthy MI, Jula A, Eriksson J, Raitakari OT, Salomaa V, Kaprio J, Järvelin MR, Peltonen L, Perola M, Freimer NB, Ala-Korpela M, Palotie A and Ripatti S

  Nature genetics 2012;44;3;269-76

  PUBMED: 22286219; PMC: 3605033; DOI: 10.1038/ng.1073

• A genome-wide screen for interactions reveals a new locus on 4p15 modifying the effect of waist-to-hip ratio on total cholesterol.

  Surakka I, Isaacs A, Karssen LC, Laurila PP, Middelberg RP, Tikkanen E, Ried JS, Lamina C, Mangino M, Igl W, Hottenga JJ, Lagou V, van der Harst P, Mateo Leach I, Esko T, Kutalik Z, Wainwright NW, Struchalin MV, Sarin AP, Kangas AJ, Viikari JS, Perola M, Rantanen T, Petersen AK, Soininen P, Johansson A, Soranzo N, Heath AC, Papamarkou T, Prokopenko I, Tönjes A, Kronenberg F, Döring A, Rivadeneira F, Montgomery GW, Whitfield JB, Kähönen M, Lehtimäki T, Freimer NB, Willemsen G, de Geus EJ, Palotie A, Sandhu MS, Waterworth DM, Metspalu A, Stumvoll M, Uitterlinden AG, Jula A, Navis G, Wijmenga C, Wolffenbuttel BH, Taskinen MR, Ala-Korpela M, Kaprio J, Kyvik KO, Boomsma DI, Pedersen NL, Gyllensten U, Wilson JF, Rudan I, Campbell H, Pramstaller PP, Spector TD, Witteman JC, Eriksson JG, Salomaa V, Oostra BA, Raitakari OT, Wichmann HE, Gieger C, Järvelin MR, Martin NG, Hofman A, McCarthy MI, Peltonen L, van Duijn CM, Aulchenko YS, Ripatti S and ENGAGE Consortium

  PLoS genetics 2011;7;10;e1002333

  PUBMED: 22028671; PMC: 3197672; DOI: 10.1371/journal.pgen.1002333

• A multilocus genetic risk score for coronary heart disease: case-control and prospective cohort analyses.

  Ripatti S, Tikkanen E, Orho-Melander M, Havulinna AS, Silander K, Sharma A, Guiducci C, Perola M, Jula A, Sinisalo J, Lokki ML, Nieminen MS, Melander O, Salomaa V, Peltonen L and Kathiresan S

  Lancet 2010;376;9750;1393-400

  PUBMED: 20971364; PMC: 2965351; DOI: 10.1016/S0140-6736(10)61267-6

• Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts.

  Aulchenko YS, Ripatti S, Lindqvist I, Boomsma D, Heid IM, Pramstaller PP, Penninx BW, Janssens AC, Wilson JF, Spector T, Martin NG, Pedersen NL, Kyvik KO, Kaprio J, Hofman A, Freimer NB, Jarvelin MR, Gyllensten U, Campbell H, Rudan I, Johansson A, Marroni F, Hayward C, Vitart V, Jonasson I, Pattaro C, Wright A, Hastie N, Pichler I, Hicks AA, Falchi M, Willemsen G, Hottenga JJ, de Geus EJ, Montgomery GW, Whitfield J, Magnusson P, Saharinen J, Perola M, Silander K, Isaacs A, Sijbrands EJ, Uitterlinden AG, Witteman JC, Oostra BA, Elliott P, Ruokonen A, Sabatti C, Gieger C, Meitinger T, Kronenberg F, Döring A, Wichmann HE, Smit JH, McCarthy MI, van Duijn CM, Peltonen L and ENGAGE Consortium

  Nature genetics 2009;41;1;47-55

  PUBMED: 19060911; PMC: 2687074; DOI: 10.1038/ng.269

• Estimation of multivariate frailty models using penalized partial likelihood.

  Ripatti S and Palmgren J

  Biometrics 2000;56;4;1016-22

  PUBMED: 11129456

Related links:

• Ripatti group