Professor Paul Kellam

Paul's laboratory investigates virus genetic variation and virus-host cell interactions. He is a Professor of Viral Pathogenesis at University College London.

Paul is the Virus Genomics team leader, Senior Investigator at the Wellcome Trust Sanger Institute and Professor of Viral Pathogenesis at University College London.

His research career has spanned pharmaceutical industry Research and Development and academic research, focusing throughout on the complex relationships between the human host and medically important viruses. Paul has a degree in Microbiology from Reading University and a PhD investigating HIV drug resistance from the Wellcome Foundation laboratories and Imperial College, London. In 1996 he joined Professor Weiss' laboratory at the Institute of Cancer Research (ICR) as a CRC research fellow. He moved to UCL in 1999, establishing his own laboratory focusing on how host and pathogen genetic variation and gene expression programs are integrated during disease and host responses to infection. At UCL, the Kellam laboratory investigates how the B-cell transcriptional environment influences the normal and tumour biology of the oncogenic herpesvirus KSHV. At the Sanger Institute the Kellam laboratory continues its host and virus interaction research investigating virus genome variation and the metavirome.

Selected Publications

• Genome-wide innate immune responses in HIV-1-infected macrophages are preserved despite attenuation of the NF-kappa B activation pathway.

  Noursadeghi M, Tsang J, Miller RF, Straschewski S, Kellam P, Chain BM and Katz DR

  Journal of immunology (Baltimore, Md. : 1950) 2009;182;1;319-28

  PUBMED: 19109163; PMC: 2637478

• Computational inference of replication and transcription activator regulator activity in herpesvirus from gene expression data.

  Recchia A, Wit E, Vinciotti V and Kellam P

  IET systems biology 2008;2;6;385-96

  PUBMED: 19045834; DOI: 10.1049/iet-syb:20070053

• X box binding protein XBP-1s transactivates the Kaposi's sarcoma-associated herpesvirus (KSHV) ORF50 promoter, linking plasma cell differentiation to KSHV reactivation from latency.

  Wilson SJ, Tsao EH, Webb BL, Ye H, Dalton-Griffin L, Tsantoulas C, Gale CV, Du MQ, Whitehouse A and Kellam P

  Journal of virology 2007;81;24;13578-86

  PUBMED: 17928342; PMC: 2168861; DOI: 10.1128/JVI.01663-07

• Robust Selection of Predictive Genes via a Simple Classifier.

  Vinciotti V, Tucker A, Kellam P and Liu X

  Applied bioinformatics 2006;5;1;1-11

  PUBMED: 16539532

• A statistical model for HIV-1 sequence classification using the subtype analyser (STAR).

  Myers RE, Gale CV, Harrison A, Takeuchi Y and Kellam P

  Bioinformatics (Oxford, England) 2005;21;17;3535-40

  PUBMED: 16046498; DOI: 10.1093/bioinformatics/bti569

• Consensus clustering and functional interpretation of gene-expression data.

  Swift S, Tucker A, Vinciotti V, Martin N, Orengo C, Liu X and Kellam P

  Genome biology 2004;5;11;R94

  PUBMED: 15535870; PMC: 545785; DOI: 10.1186/gb-2004-5-11-r94

• Kaposi's sarcoma-associated herpesvirus-infected primary effusion lymphoma has a plasma cell gene expression profile.

  Jenner RG, Maillard K, Cattini N, Weiss RA, Boshoff C, Wooster R and Kellam P

  Proceedings of the National Academy of Sciences of the United States of America 2003;100;18;10399-404

  PUBMED: 12925741; PMC: 193573; DOI: 10.1073/pnas.1630810100

Related links

• Global health research