Honorary Faculty - Dr Martin Donnelly

Martin Donnelly is Reader of Vector Biology at the Liverpool School of Tropical Medicine. He works in collaboration with the Sanger Institute Malaria Programme and focuses on insecticide resistance in the malaria mosquito Anopheles gambiae.

Martin's group studies the evolutionary genetics of insect disease vectors. A major area of interest is the evolution of insecticide resistance in the malaria mosquito Anopheles gambiae. Working in collaboration with Dominic Kwiatkowski and the Sanger Institute Malaria Programme, Martin's group leverages the power of next-generation sequencing technologies to address aspects of the biology of Anopheles gambiae that impact upon the sustainable control of malaria. This includes genome wide association studies (GWAS) to identify genetic loci associated with insecticide resistance and population genetic studies to describe population sub-structuring.

Martin Donnelly trained at Girton College, Cambridge University (MA) and the Liverpool School of Tropical Medicine (MSc, PhD). He was then awarded an American Society of Microbiology Fellowship and spent two years in the laboratory of Dr Tovi Lehmann at the Centers for Disease Control and Prevention (CDC) in Atlanta, USA (1999-2001). He rejoined the Vector Group at the Liverpool School of Tropical Medicine in 2001.

Selected Publications

  • A cis-regulatory sequence driving metabolic insecticide resistance in mosquitoes: functional characterisation and signatures of selection.

    Wilding CS, Smith I, Lynd A, Yawson AE, Weetman D, Paine MJ and Donnelly MJ

    Insect biochemistry and molecular biology 2012;42;9;699-707

  • Footprints of positive selection associated with a mutation (N1575Y) in the voltage-gated sodium channel of Anopheles gambiae.

    Jones CM, Liyanapathirana M, Agossa FR, Weetman D, Ranson H, Donnelly MJ and Wilding CS

    Proceedings of the National Academy of Sciences of the United States of America 2012;109;17;6614-9

  • Identification and validation of a gene causing cross-resistance between insecticide classes in Anopheles gambiae from Ghana.

    Mitchell SN, Stevenson BJ, Müller P, Wilding CS, Egyir-Yawson A, Field SG, Hemingway J, Paine MJ, Ranson H and Donnelly MJ

    Proceedings of the National Academy of Sciences of the United States of America 2012;109;16;6147-52

  • Malaria in Uganda: challenges to control on the long road to elimination: I. Epidemiology and current control efforts.

    Yeka A, Gasasira A, Mpimbaza A, Achan J, Nankabirwa J, Nsobya S, Staedke SG, Donnelly MJ, Wabwire-Mangen F, Talisuna A, Dorsey G, Kamya MR and Rosenthal PJ

    Acta tropica 2012;121;3;184-95

  • Comparative genomics of the anopheline glutathione S-transferase epsilon cluster.

    Ayres CF, Ayres C, Müller P, Dyer N, Wilding CS, Wilding C, Rigden DJ, Rigden D, Donnelly MJ and Donnelly M

    PloS one 2011;6;12;e29237

* quick link - http://q.sanger.ac.uk/b2mrdncd