Dr Matt Berriman
Matt leads a programme in the genomics of Neglected Tropical Disease parasites, including helminths such as Schistomosomes, tapeworms, roundworms, hookworms, threadworms and whipworms.
Matt graduated in 1994 from the University of Manchester with a degree in biochemistry.
He moved to the London School of Hygiene and Tropical Medicine at the University of Dundee to undertake a PhD with Professor Alan Fairlamb, biochemically characterising a putative drug target from the malaria parasite Plasmodium falciparum. After being awarded a Wellcome Trust Travelling Prize Fellowship, Matt moved to the laboratory of Professor George Cross at Rockefeller University in New York to study Trypanosome telomeres. At the end of 2000, he joined the Wellcome Trust Sanger Institute as a Senior Computer Biologist in the Pathogen Sequencing Unit. There, he analysed and annotated the genomes of Plasmodium falciparum and Trypanosoma brucei. From 2003, Matt took over the leadership of more than 20 eukaryotic pathogen sequencing projects, primarily focused on the medically important Apicomplexan and Kinetoplastid protozoa, which include malaria parasites and trypanosomes, respectively. Matt joined the faculty in 2008 and is leading a programme in the genomics of Neglected Tropical Disease parasites, which include parasitic helminths such as Schistomosomes, tapeworms, roundworms, hookworms, threadworms and whipworms.
Selected Publications
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Plasmodium falciparum var gene expression is modified by host immunity.
Proceedings of the National Academy of Sciences of the United States of America 2009;106;51;21801-6
PUBMED: 20018734; PMC: 2792160; DOI: 10.1073/pnas.0907590106
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Comparative genomics of the fungal pathogens Candida dubliniensis and Candida albicans.
Genome research 2009;19;12;2231-44
PUBMED: 19745113; PMC: 2792176; DOI: 10.1101/gr.097501.109
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The genome of the blood fluke Schistosoma mansoni.
Nature 2009;460;7253;352-8
PUBMED: 19606141; PMC: 2756445; DOI: 10.1038/nature08160
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Artemis and ACT: viewing, annotating and comparing sequences stored in a relational database.
Bioinformatics (Oxford, England) 2008;24;23;2672-6
PUBMED: 18845581; PMC: 2606163; DOI: 10.1093/bioinformatics/btn529
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Genetics of mating and sex determination in the parasitic nematode Haemonchus contortus.
Genetics 2008;180;4;1877-87
PUBMED: 18854587; PMC: 2600929; DOI: 10.1534/genetics.108.094623
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Genomic-scale prioritization of drug targets: the TDR Targets database.
Nature reviews. Drug discovery 2008;7;11;900-7
PUBMED: 18927591; PMC: 3184002; DOI: 10.1038/nrd2684
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The genome of the simian and human malaria parasite Plasmodium knowlesi.
Nature 2008;455;7214;799-803
PUBMED: 18843368; PMC: 2656934; DOI: 10.1038/nature07306
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Genome-wide discovery and verification of novel structured RNAs in Plasmodium falciparum.
Genome research 2008;18;2;281-92
PUBMED: 18096748; PMC: 2203626; DOI: 10.1101/gr.6836108
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Insights into the genome sequence of a free-living Kinetoplastid: Bodo saltans (Kinetoplastida: Euglenozoa).
BMC genomics 2008;9;594
PUBMED: 19068121; PMC: 2621209; DOI: 10.1186/1471-2164-9-594
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Telomeric expression sites are highly conserved in Trypanosoma brucei.
PloS one 2008;3;10;e3527
PUBMED: 18953401; PMC: 2567434; DOI: 10.1371/journal.pone.0003527
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Comparative genomic analysis of three Leishmania species that cause diverse human disease.
Nature genetics 2007;39;7;839-47
PUBMED: 17572675; PMC: 2592530; DOI: 10.1038/ng2053
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Genome variation and evolution of the malaria parasite Plasmodium falciparum.
Nature genetics 2007;39;1;120-5
PUBMED: 17159978; PMC: 2663918; DOI: 10.1038/ng1931
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The genome of the African trypanosome Trypanosoma brucei.
Science (New York, N.Y.) 2005;309;5733;416-22
PUBMED: 16020726; DOI: 10.1126/science.1112642

