Honorary Faculty - Dr Ian Humphreys

Ian Humphreys is a Wellcome Trust Senior Research Fellow in Basic Biomedical Science at Cardiff University. His laboratory studies the immunological mechanisms that influence host control of herpesvirus infections. Ian collaborates with Paul Kellam's and Gordon Dougan's research groups to understand the influence of host genetics on antiviral immunity.

Ian graduated from the University of Warwick in 2000 with a BSc in Biological Sciences with Virology. He received a PhD in Biochemistry in 2004 from Imperial College London after studying T-cell costimulatory signalling in respiratory viral infections, in the laboratories of Tracy Hussell and Gordon Dougan.

Ian performed his postdoctoral training first with Douglas Young at Imperial College, and then in the laboratories of Carl Ware and Mick Croft at the La Jolla Institute for Allergy and Immunology where he investigated the role of TNF receptor family members in cytomegalovirus infection. In 2007, Ian was awarded a Wellcome Trust Research Career Development Fellowship to establish his own group in Cardiff University. In 2012, Ian was awarded a Wellcome Trust Senior Research Fellowship in Basic Biomedical Science. The primary focus of his group is to understand the role that cytokines play in immune regulation and antiviral control during acute and chronic cytomegalovirus infection.

Selected Publications

  • Neutrophils recruited by IL-22 in peripheral tissues function as TRAIL-dependent antiviral effectors against MCMV.

    Stacey MA, Marsden M, Pham N TA, Clare S, Dolton G, Stack G, Jones E, Klenerman P, Gallimore AM, Taylor PR, Snelgrove RJ, Lawley TD, Dougan G, Benedict CA, Jones SA, Wilkinson GW and Humphreys IR

    Cell host & microbe 2014;15;4;471-83

  • Interleukin-6 signaling drives fibrosis in unresolved inflammation.

    Fielding CA, Jones GW, McLoughlin RM, McLeod L, Hammond VJ, Uceda J, Williams AS, Lambie M, Foster TL, Liao CT, Rice CM, Greenhill CJ, Colmont CS, Hams E, Coles B, Kift-Morgan A, Newton Z, Craig KJ, Williams JD, Williams GT, Davies SJ, Humphreys IR, O'Donnell VB, Taylor PR, Jenkins BJ, Topley N and Jones SA

    Immunity 2014;40;1;40-50

  • The death receptor 3/TL1A pathway is essential for efficient development of antiviral CD4⁺ and CD8⁺ T-cell immunity.

    Twohig JP, Marsden M, Cuff SM, Ferdinand JR, Gallimore AM, Perks WV, Al-Shamkhani A, Humphreys IR and Wang EC

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012;26;8;3575-86

  • IL-10 restricts activation-induced death of NK cells during acute murine cytomegalovirus infection.

    Stacey MA, Marsden M, Wang EC, Wilkinson GW and Humphreys IR

    Journal of immunology (Baltimore, Md. : 1950) 2011;187;6;2944-52

  • IL-10 restricts memory T cell inflation during cytomegalovirus infection.

    Jones M, Ladell K, Wynn KK, Stacey MA, Quigley MF, Gostick E, Price DA and Humphreys IR

    Journal of immunology (Baltimore, Md. : 1950) 2010;185;6;3583-92

  • Cytomegalovirus exploits IL-10-mediated immune regulation in the salivary glands.

    Humphreys IR, de Trez C, Kinkade A, Benedict CA, Croft M and Ware CF

    The Journal of experimental medicine 2007;204;5;1217-25

  • Evolutionarily divergent herpesviruses modulate T cell activation by targeting the herpesvirus entry mediator cosignaling pathway.

    Cheung TC, Humphreys IR, Potter KG, Norris PS, Shumway HM, Tran BR, Patterson G, Jean-Jacques R, Yoon M, Spear PG, Murphy KM, Lurain NS, Benedict CA and Ware CF

    Proceedings of the National Academy of Sciences of the United States of America 2005;102;37;13218-23

* quick link - http://q.sanger.ac.uk/zbwbj1m0