Dr Darren Logan

Darren's laboratory aims to understand the genes that enable animals to detect and respond to social signals with an appropriate behaviour.

In 1999 Darren graduated from the University of Bath with a Master's degree in Biochemistry before moving to the MRC Human Genetics Unit in Edinburgh. He joined Professor Ian Jackson's lab to undertake a PhD studying the evolution and function of genes that control pigmentation.

Having explored the molecular mechanisms through which some species instinctively change colour to facilitate camouflage, Darren next wanted to understand how mammals communicate to initiate more complex social behaviours.

He moved to The Scripps Research Institute to join Lisa Stowers' group, where he was awarded a Skaggs Fellowship to investigate how mice provoke suckling behaviour in their young. During his time in California, Darren also characterized a novel family of protein pheromones that proved to be the first published example of genetically-encoded signals that initiate a range of innate behaviours in mice, including inter-male aggression, dominance, and fear of predators.

In 2010 Darren joined the Wellcome Trust Sanger Institute faculty. Using mouse models of human behavioural and intellectual disorders, his team combines large-scale transcriptional profiling, behavioural testing, and neural activation studies to identify and investigate genes that regulate behaviour and cognition.

Selected Publications

  • The olfactory transcriptomes of mice.

    Ibarra-Soria X, Levitin MO, Saraiva LR and Logan DW

    PLoS genetics 2014;10;9;e1004593

  • Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes.

    White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Sanger Institute Mouse Genetics Project, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A and Steel KP

    Cell 2013;154;2;452-64

  • Learned recognition of maternal signature odors mediates the first suckling episode in mice.

    Logan DW, Brunet LJ, Webb WR, Cutforth T, Ngai J and Stowers L

    Current biology : CB 2012;22;21;1998-2007

  • Disruption of mouse Cenpj, a regulator of centriole biogenesis, phenocopies Seckel syndrome.

    McIntyre RE, Lakshminarasimhan Chavali P, Ismail O, Carragher DM, Sanchez-Andrade G, Forment JV, Fu B, Del Castillo Velasco-Herrera M, Edwards A, van der Weyden L, Yang F, Sanger Mouse Genetics Project, Ramirez-Solis R, Estabel J, Gallagher FA, Logan DW, Arends MJ, Tsang SH, Mahajan VB, Scudamore CL, White JK, Jackson SP, Gergely F and Adams DJ

    PLoS genetics 2012;8;11;e1003022

  • Genomic variation in the vomeronasal receptor gene repertoires of inbred mice.

    Wynn EH, Sánchez-Andrade G, Carss KJ and Logan DW

    BMC genomics 2012;13;415

  • The vomeronasal organ mediates interspecies defensive behaviors through detection of protein pheromone homologs.

    Papes F, Logan DW and Stowers L

    Cell 2010;141;4;692-703

  • Species specificity in major urinary proteins by parallel evolution.

    Logan DW, Marton TF and Stowers L

    PloS one 2008;3;9;e3280

  • Identification of protein pheromones that promote aggressive behaviour.

    Chamero P, Marton TF, Logan DW, Flanagan K, Cruz JR, Saghatelian A, Cravatt BF and Stowers L

    Nature 2007;450;7171;899-902

[Wellcome Library, London]

Darren's Project
Genetics of behaviour
Research Area
Mouse & Zebrafish
Email
dl5@sanger.ac.uk
* quick link - http://q.sanger.ac.uk/npdtuytm