Professor Dominic Kwiatkowski

Dominic leads the Sanger Institute Malaria Programme, which uses genomic and genetic approaches to discover molecular mechanisms of host-parasite interactions.

Dominic is a clinical researcher working on malaria and other childhood diseases of the developing world.

He joined the Wellcome Trust Sanger Institute in 2006 to lead the Malaria Programme, as a part of the Institute's programme in Pathogen Genetics. He also maintains a joint appointment - and a busy laboratory - at the University of Oxford, where he is a Medical Research Council (MRC) Clinical Research Professor in the Department of Paediatrics.

Although separated by geography, Dominic's team works together to bridge the complementary strengths of the Sanger Institute, where they are the Malaria Programme: Kwiatkowski Group, and the University of Oxford, by combining high-throughput genomic approaches with large-scale clinical epidemiology studies to investigate biological mechanisms of disease.

One of the team's major tasks across both sites is to coordinate MalariaGEN, a network of malaria researchers in 20 countries, which aims to accelerate vaccine development by discovering natural mechanisms of protective immunity to malaria.

Selected Publications

Characterization of within-host Plasmodium falciparum diversity using next-generation sequence data.

Auburn S, Campino S, Miotto O, Djimde AA, Zongo I, Manske M, Maslen G, Mangano V, Alcock D, MacInnis B, Rockett KA, Clark TG, Doumbo OK, Ouédraogo JB and Kwiatkowski DP

PloS one 2012;7;2;e32891

PUBMED: 22393456; PMC: 3290604; DOI: 10.1371/journal.pone.0032891
Optimizing Illumina next-generation sequencing library preparation for extremely AT-biased genomes.

Oyola SO, Otto TD, Gu Y, Maslen G, Manske M, Campino S, Turner DJ, Macinnis B, Kwiatkowski DP, Swerdlow HP and Quail MA

BMC genomics 2012;13;1

PUBMED: 22214261; PMC: 3312816; DOI: 10.1186/1471-2164-13-1
An effective method to purify Plasmodium falciparum DNA directly from clinical blood samples for whole genome high-throughput sequencing.

Auburn S, Campino S, Clark TG, Djimde AA, Zongo I, Pinches R, Manske M, Mangano V, Alcock D, Anastasi E, Maslen G, Macinnis B, Rockett K, Modiano D, Newbold CI, Doumbo OK, Ouédraogo JB and Kwiatkowski DP

PloS one 2011;6;7;e22213

PUBMED: 21789235; PMC: 3138765; DOI: 10.1371/journal.pone.0022213
Ethical issues in human genomics research in developing countries.

de Vries J, Bull SJ, Doumbo O, Ibrahim M, Mercereau-Puijalon O, Kwiatkowski D and Parker M

BMC medical ethics 2011;12;5

PUBMED: 21418562; PMC: 3076260; DOI: 10.1186/1472-6939-12-5
Population genetic analysis of Plasmodium falciparum parasites using a customized Illumina GoldenGate genotyping assay.

Campino S, Auburn S, Kivinen K, Zongo I, Ouedraogo JB, Mangano V, Djimde A, Doumbo OK, Kiara SM, Nzila A, Borrmann S, Marsh K, Michon P, Mueller I, Siba P, Jiang H, Su XZ, Amaratunga C, Socheat D, Fairhurst RM, Imwong M, Anderson T, Nosten F, White NJ, Gwilliam R, Deloukas P, MacInnis B, Newbold CI, Rockett K, Clark TG and Kwiatkowski DP

PloS one 2011;6;6;e20251

PUBMED: 21673999; PMC: 3108946; DOI: 10.1371/journal.pone.0020251
Methodological challenges of genome-wide association analysis in Africa.

Teo YY, Small KS and Kwiatkowski DP

Nature reviews. Genetics 2010;11;2;149-60

PUBMED: 20084087; PMC: 3769612; DOI: 10.1038/nrg2731
Ethical data release in genome-wide association studies in developing countries.

Parker M, Bull SJ, de Vries J, Agbenyega T, Doumbo OK and Kwiatkowski DP

PLoS medicine 2009;6;11;e1000143

PUBMED: 19956792; PMC: 2771895; DOI: 10.1371/journal.pmed.1000143
LookSeq: a browser-based viewer for deep sequencing data.

Manske HM and Kwiatkowski DP

Genome research 2009;19;11;2125-32

PUBMED: 19679872; PMC: 2775587; DOI: 10.1101/gr.093443.109
SNP-o-matic.

Manske HM and Kwiatkowski DP

Bioinformatics (Oxford, England) 2009;25;18;2434-5

PUBMED: 19574284; PMC: 2735664; DOI: 10.1093/bioinformatics/btp403
Genome-wide and fine-resolution association analysis of malaria in West Africa.

Jallow M, Teo YY, Small KS, Rockett KA, Deloukas P, Clark TG, Kivinen K, Bojang KA, Conway DJ, Pinder M, Sirugo G, Sisay-Joof F, Usen S, Auburn S, Bumpstead SJ, Campino S, Coffey A, Dunham A, Fry AE, Green A, Gwilliam R, Hunt SE, Inouye M, Jeffreys AE, Mendy A, Palotie A, Potter S, Ragoussis J, Rogers J, Rowlands K, Somaskantharajah E, Whittaker P, Widden C, Donnelly P, Howie B, Marchini J, Morris A, SanJoaquin M, Achidi EA, Agbenyega T, Allen A, Amodu O, Corran P, Djimde A, Dolo A, Doumbo OK, Drakeley C, Dunstan S, Evans J, Farrar J, Fernando D, Hien TT, Horstmann RD, Ibrahim M, Karunaweera N, Kokwaro G, Koram KA, Lemnge M, Makani J, Marsh K, Michon P, Modiano D, Molyneux ME, Mueller I, Parker M, Peshu N, Plowe CV, Puijalon O, Reeder J, Reyburn H, Riley EM, Sakuntabhai A, Singhasivanon P, Sirima S, Tall A, Taylor TE, Thera M, Troye-Blomberg M, Williams TN, Wilson M, Kwiatkowski DP, Wellcome Trust Case Control Consortium and Malaria Genomic Epidemiology Network

Nature genetics 2009;41;6;657-65

PUBMED: 19465909; PMC: 2889040; DOI: 10.1038/ng.388
Tumor necrosis factor and lymphotoxin-alpha polymorphisms and severe malaria in African populations.

Clark TG, Diakite M, Auburn S, Campino S, Fry AE, Green A, Richardson A, Small K, Teo YY, Wilson J, Jallow M, Sisay-Joof F, Pinder M, Griffiths MJ, Peshu N, Williams TN, Marsh K, Molyneux ME, Taylor TE, Rockett KA and Kwiatkowski DP

The Journal of infectious diseases 2009;199;4;569-75

PUBMED: 19281305; PMC: 2742199; DOI: 10.1086/596320
TLR9 polymorphisms in African populations: no association with severe malaria, but evidence of cis-variants acting on gene expression.

Campino S, Forton J, Auburn S, Fry A, Diakite M, Richardson A, Hull J, Jallow M, Sisay-Joof F, Pinder M, Molyneux ME, Taylor TE, Rockett K, Clark TG and Kwiatkowski DP

Malaria journal 2009;8;44

PUBMED: 19284650; PMC: 2660361; DOI: 10.1186/1475-2875-8-44
A global network for investigating the genomic epidemiology of malaria.

Malaria Genomic Epidemiology Network

Nature 2008;456;7223;732-7

PUBMED: 19079050; PMC: 3758999; DOI: 10.1038/nature07632
Host genetic factors in resistance and susceptibility to malaria.

Kwiatkowski DP and Luoni G

Parassitologia 2006;48;4;450-67

PUBMED: 17688174
Data sharing and intellectual property in a genomic epidemiology network: policies for large-scale research collaboration.

Chokshi DA, Parker M and Kwiatkowski DP

Bulletin of the World Health Organization 2006;84;5;382-7

PUBMED: 16710548; PMC: 2627357; DOI: /S0042-96862006000500018
How malaria has affected the human genome and what human genetics can teach us about malaria.

Kwiatkowski DP

American journal of human genetics 2005;77;2;171-92

PUBMED: 16001361; PMC: 1224522; DOI: 10.1086/432519

Professor Dominic Kwiatkowski

Selected Publications

Characterization of within-host Plasmodium falciparum diversity using next-generation sequence data.

Optimizing Illumina next-generation sequencing library preparation for extremely AT-biased genomes.

An effective method to purify Plasmodium falciparum DNA directly from clinical blood samples for whole genome high-throughput sequencing.

Ethical issues in human genomics research in developing countries.

Population genetic analysis of Plasmodium falciparum parasites using a customized Illumina GoldenGate genotyping assay.

Methodological challenges of genome-wide association analysis in Africa.

Ethical data release in genome-wide association studies in developing countries.

LookSeq: a browser-based viewer for deep sequencing data.

SNP-o-matic.

Genome-wide and fine-resolution association analysis of malaria in West Africa.

Tumor necrosis factor and lymphotoxin-alpha polymorphisms and severe malaria in African populations.

TLR9 polymorphisms in African populations: no association with severe malaria, but evidence of cis-variants acting on gene expression.

A global network for investigating the genomic epidemiology of malaria.

Host genetic factors in resistance and susceptibility to malaria.

Data sharing and intellectual property in a genomic epidemiology network: policies for large-scale research collaboration.

How malaria has affected the human genome and what human genetics can teach us about malaria.

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