Dr David Adams

David performs forward genetic screens to uncover cancer genes and pathways and leads a programme to decode the genomes of several mouse strains.

David graduated from the University of Technology, Sydney with a BSc (Hons) in Biomedical Science in 1996 having specialised in pathology, haematology and molecular genetics.

He worked in clinical diagnostic laboratories before moving to the Department of Physiology at the University of Sydney to undertake a PhD with Professor Brian Morris, which was completed in 2001. David then moved to the Wellcome Trust Sanger Institute in late 2001 to start a postdoc with Professor Allan Bradley. In Allan Bradley's lab David developed an interest in cancer genetics, refined technologies for modifying the mouse genome and developed a large number of mouse models to study disease gene function. In 2006 David was awarded a Cancer Research UK Career Development Fellowship and joined the faculty of the Sanger Institute. As a faculty member David is performing forward genetic screens to uncover cancer genes and cancer pathways and is also leading a programme to use new-technology sequencing to decode the genomes of several mouse strains which form the basis of mouse experimental genetics. In addition to being a faculty member at the Sanger Institute David is also adjunct-faculty at the Cambridge Cancer Research Institute and works closely with a number of scientists throughout the Cambridge research community.

Selected Publications

• Loss of Rassf1a cooperates with Apc(Min) to accelerate intestinal tumourigenesis.

  van der Weyden L, Arends MJ, Dovey OM, Harrison HL, Lefebvre G, Conte N, Gergely FV, Bradley A and Adams DJ

  Oncogene 2008;27;32;4503-8

  PUBMED: 18391979; DOI: 10.1038/onc.2008.94

• Large-scale mutagenesis in p19(ARF)- and p53-deficient mice identifies cancer genes and their collaborative networks.

  Uren AG, Kool J, Matentzoglu K, de Ridder J, Mattison J, van Uitert M, Lagcher W, Sie D, Tanger E, Cox T, Reinders M, Hubbard TJ, Rogers J, Jonkers J, Wessels L, Adams DJ, van Lohuizen M and Berns A

  Cell 2008;133;4;727-41

  PUBMED: 18485879; DOI: 10.1016/j.cell.2008.03.021; PMC: 2405818

• Normal germ line establishment in mice carrying a deletion of the Ifitm/Fragilis gene family cluster.

  Lange UC, Adams DJ, Lee C, Barton S, Schneider R, Bradley A and Surani MA

  Molecular and cellular biology 2008;28;15;4688-96

  PUBMED: 18505827; DOI: 10.1128/MCB.00272-08; PMC: 2493357

• The Ras-association domain family (RASSF) members and their role in human tumourigenesis.

  van der Weyden L and Adams DJ

  Biochimica et biophysica acta 2007;1776;1;58-85

  PUBMED: 17692468; DOI: 10.1016/j.bbcan.2007.06.003; PMC: 2586335

• Renin enhancer is critical for control of renin gene expression and cardiovascular function.

  Adams DJ, Head GA, Markus MA, Lovicu FJ, van der Weyden L, Köntgen F, Arends MJ, Thiru S, Mayorov DN and Morris BJ

  The Journal of biological chemistry 2006;281;42;31753-61

  PUBMED: 16895910; DOI: 10.1074/jbc.M605720200

• Functional knockout of the matrilin-3 gene causes premature chondrocyte maturation to hypertrophy and increases bone mineral density and osteoarthritis.

  van der Weyden L, Wei L, Luo J, Yang X, Birk DE, Adams DJ, Bradley A and Chen Q

  The American journal of pathology 2006;169;2;515-27

  PUBMED: 16877353; PMC: 1698783

• TranscriptSNPView: a genome-wide catalog of mouse coding variation.

  Cunningham F, Rios D, Griffiths M, Smith J, Ning Z, Cox T, Flicek P, Marin-Garcin P, Herrero J, Rogers J, van der Weyden L, Bradley A, Birney E and Adams DJ

  Nature genetics 2006;38;8;853

  PUBMED: 16874317; DOI: 10.1038/ng0806-853a; PMC: 2610433

• Geminin is essential to prevent endoreduplication and to form pluripotent cells during mammalian development.

  Gonzalez MA, Tachibana KE, Adams DJ, van der Weyden L, Hemberger M, Coleman N, Bradley A and Laskey RA

  Genes & development 2006;20;14;1880-4

  PUBMED: 16847348; DOI: 10.1101/gad.379706; PMC: 1522086

• DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

  Zody MC, Garber M, Adams DJ, Sharpe T, Harrow J, Lupski JR, Nicholson C, Searle SM, Wilming L, Young SK, Abouelleil A, Allen NR, Bi W, Bloom T, Borowsky ML, Bugalter BE, Butler J, Chang JL, Chen CK, Cook A, Corum B, Cuomo CA, de Jong PJ, DeCaprio D, Dewar K, FitzGerald M, Gilbert J, Gibson R, Gnerre S, Goldstein S, Grafham DV, Grocock R, Hafez N, Hagopian DS, Hart E, Norman CH, Humphray S, Jaffe DB, Jones M, Kamal M, Khodiyar VK, LaButti K, Laird G, Lehoczky J, Liu X, Lokyitsang T, Loveland J, Lui A, Macdonald P, Major JE, Matthews L, Mauceli E, McCarroll SA, Mihalev AH, Mudge J, Nguyen C, Nicol R, O'Leary SB, Osoegawa K, Schwartz DC, Shaw-Smith C, Stankiewicz P, Steward C, Swarbreck D, Venkataraman V, Whittaker CA, Yang X, Zimmer AR, Bradley A, Hubbard T, Birren BW, Rogers J, Lander ES and Nusbaum C

  Nature 2006;440;7087;1045-9

  PUBMED: 16625196; DOI: 10.1038/nature04689; PMC: 2610434

• Loss of TSLC1 causes male infertility due to a defect at the spermatid stage of spermatogenesis.

  van der Weyden L, Arends MJ, Chausiaux OE, Ellis PJ, Lange UC, Surani MA, Affara N, Murakami Y, Adams DJ and Bradley A

  Molecular and cellular biology 2006;26;9;3595-609

  PUBMED: 16611999; DOI: 10.1128/MCB.26.9.3595-3609.2006; PMC: 1447413