Dr David Adams

David performs forward genetic screens to uncover cancer genes and pathways and leads a programme to decode the genomes of several mouse strains.

He also leads the Mouse Genomes Project and the Mouse Genetics Project. The Mouse Genomes Project is sequencing and assembling mouse strain genomes while the Mouse Genetics Project is part of the International Mouse Phenotyping Consortium and aims to generate phenotyping data for over 200 genetically modified mouse lines per year to gain a better understanding of mammalian gene function.

David graduated from the University of Technology, Sydney with a BSc (Hons) in Biomedical Science in 1996 having specialised in pathology, haematology and molecular genetics. He worked in clinical diagnostic laboratories before moving to the Department of Physiology at the University of Sydney to undertake a PhD with Professor Brian Morris, which was completed in 2001. David then moved to the Wellcome Trust Sanger Institute in late 2001 to start a postdoc with Professor Allan Bradley. In Allan Bradley's lab David developed an interest in cancer genetics, refined technologies for modifying the mouse genome and developed a large number of mouse models to study disease gene function. In 2006 David was awarded a Cancer Research UK Career Development Fellowship and joined the faculty of the Sanger Institute. In 2012 David became a CR-UK Senior fellow. David is adjunct-faculty at the Cambridge Cancer Research Institute and works closely with a number of scientists throughout the Cambridge research community.

Publications

  • High-throughput semiquantitative analysis of insertional mutations in heterogeneous tumors.

    Koudijs MJ, Klijn C, van der Weyden L, Kool J, ten Hoeve J, Sie D, Prasetyanti PR, Schut E, Kas S, Whipp T, Cuppen E, Wessels L, Adams DJ and Jonkers J

    Genome research2011;21;12;2181-9

    PUBMED: 21852388; PMC: 3227106; DOI: 10.1101/gr.112763.110

  • Insertional mutagenesis identifies multiple networks of cooperating genes driving intestinal tumorigenesis.

    March HN, Rust AG, Wright NA, ten Hoeve J, de Ridder J, Eldridge M, van der Weyden L, Berns A, Gadiot J, Uren A, Kemp R, Arends MJ, Wessels LF, Winton DJ and Adams DJ

    Nature genetics2011;43;12;1202-9

    PUBMED: 22057237; PMC: 3233530; DOI: 10.1038/ng.990

  • In vivo identification of tumor- suppressive PTEN ceRNAs in an oncogenic BRAF-induced mouse model of melanoma.

    Karreth FA, Tay Y, Perna D, Ala U, Tan SM, Rust AG, DeNicola G, Webster KA, Weiss D, Perez-Mancera PA, Krauthammer M, Halaban R, Provero P, Adams DJ, Tuveson DA and Pandolfi PP

    Cell2011;147;2;382-95

    PUBMED: 22000016; PMC: 3236086; DOI: 10.1016/j.cell.2011.09.032

  • Exome sequencing identifies a missense mutation in Isl1 associated with low penetrance otitis media in dearisch mice.

    Hilton JM, Lewis MA, Grati M, Ingham N, Pearson S, Laskowski RA, Adams DJ and Steel KP

    Genome biology2011;12;9;R90

    PUBMED: 21936904; DOI: 10.1186/gb-2011-12-9-r90

  • Mouse genomic variation and its effect on phenotypes and gene regulation.

    Keane TM, Goodstadt L, Danecek P, White MA, Wong K, Yalcin B, Heger A, Agam A, Slater G, Goodson M, Furlotte NA, Eskin E, Nellåker C, Whitley H, Cleak J, Janowitz D, Hernandez-Pliego P, Edwards A, Belgard TG, Oliver PL, McIntyre RE, Bhomra A, Nicod J, Gan X, Yuan W, van der Weyden L, Steward CA, Bala S, Stalker J, Mott R, Durbin R, Jackson IJ, Czechanski A, Guerra-Assunção JA, Donahue LR, Reinholdt LG, Payseur BA, Ponting CP, Birney E, Flint J and Adams DJ

    Nature2011;477;7364;289-94

    PUBMED: 21921910; DOI: 10.1038/nature10413

  • Sequence-based characterization of structural variation in the mouse genome.

    Yalcin B, Wong K, Agam A, Goodson M, Keane TM, Gan X, Nellåker C, Goodstadt L, Nicod J, Bhomra A, Hernandez-Pliego P, Whitley H, Cleak J, Dutton R, Janowitz D, Mott R, Adams DJ and Flint J

    Nature2011;477;7364;326-9

    PUBMED: 21921916; DOI: 10.1038/nature10432

  • A role for cohesin in T-cell-receptor rearrangement and thymocyte differentiation.

    Seitan VC, Hao B, Tachibana-Konwalski K, Lavagnolli T, Mira-Bontenbal H, Brown KE, Teng G, Carroll T, Terry A, Horan K, Marks H, Adams DJ, Schatz DG, Aragon L, Fisher AG, Krangel MS, Nasmyth K and Merkenschlager M

    Nature2011;476;7361;467-71

    PUBMED: 21832993; PMC: 3179485; DOI: 10.1038/nature10312

  • Computational identification of insertional mutagenesis targets for cancer gene discovery.

    de Jong J, de Ridder J, van der Weyden L, Sun N, van Uitert M, Berns A, van Lohuizen M, Jonkers J, Adams DJ and Wessels LF

    Nucleic acids research2011;39;15;e105

    PUBMED: 21652642; PMC: 3159484; DOI: 10.1093/nar/gkr447

  • Modeling the evolution of ETV6-RUNX1-induced B-cell precursor acute lymphoblastic leukemia in mice.

    van der Weyden L, Giotopoulos G, Rust AG, Matheson LS, van Delft FW, Kong J, Corcoran AE, Greaves MF, Mullighan CG, Huntly BJ and Adams DJ

    Blood2011;118;4;1041-51

    PUBMED: 21628403; DOI: 10.1182/blood-2011-02-338848

  • Acute sensitivity of the oral mucosa to oncogenic K-ras.

    van der Weyden L, Alcolea MP, Jones PH, Rust AG, Arends MJ and Adams DJ

    The Journal of pathology2011;224;1;22-32

    PUBMED: 21381032; DOI: 10.1002/path.2853

  • Shotgun proteomics aids discovery of novel protein-coding genes, alternative splicing, and "resurrected" pseudogenes in the mouse genome.

    Brosch M, Saunders GI, Frankish A, Collins MO, Yu L, Wright J, Verstraten R, Adams DJ, Harrow J, Choudhary JS and Hubbard T

    Genome research2011;21;5;756-67

    PUBMED: 21460061; PMC: 3083093; DOI: 10.1101/gr.114272.110

  • Disruption of mouse Slx4, a regulator of structure-specific nucleases, phenocopies Fanconi anemia.

    Crossan GP, van der Weyden L, Rosado IV, Langevin F, Gaillard PH, McIntyre RE, Sanger Mouse Genetics Project, Gallagher F, Kettunen MI, Lewis DY, Brindle K, Arends MJ, Adams DJ and Patel KJ

    Nature genetics2011;43;2;147-52

    PUBMED: 21240276; DOI: 10.1038/ng.752

  • Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma.

    Varela I, Tarpey P, Raine K, Huang D, Ong CK, Stephens P, Davies H, Jones D, Lin ML, Teague J, Bignell G, Butler A, Cho J, Dalgliesh GL, Galappaththige D, Greenman C, Hardy C, Jia M, Latimer C, Lau KW, Marshall J, McLaren S, Menzies A, Mudie L, Stebbings L, Largaespada DA, Wessels LF, Richard S, Kahnoski RJ, Anema J, Tuveson DA, Perez-Mancera PA, Mustonen V, Fischer A, Adams DJ, Rust A, Chan-on W, Subimerb C, Dykema K, Furge K, Campbell PJ, Teh BT, Stratton MR and Futreal PA

    Nature2011;469;7331;539-42

    PUBMED: 21248752; PMC: 3030920; DOI: 10.1038/nature09639

  • Activation of K-RAS by co-mutation of codons 19 and 20 is transforming.

    Naguib A, Wilson CH, Adams DJ and Arends MJ

    Journal of molecular signaling2011;6;2

    PUBMED: 21371307; PMC: 3056876; DOI: 10.1186/1750-2187-6-2

  • Sequencing skippy: the genome sequence of an Australian kangaroo, Macropus eugenii.

    Murchison EP and Adams DJ

    Genome biology2011;12;8;123

    PUBMED: 21861852; PMC: 3245606; DOI: 10.1186/gb-2011-12-8-123

  • The mouse genetics toolkit: revealing function and mechanism.

    van der Weyden L, White JK, Adams DJ and Logan DW

    Genome biology2011;12;6;224

    PUBMED: 21722353; PMC: 3218837; DOI: 10.1186/gb-2011-12-6-224

Publications 2010

  • Slingshot: a PiggyBac based transposon system for tamoxifen-inducible 'self-inactivating' insertional mutagenesis.

    Kong J, Wang F, Brenton JD and Adams DJ

    Nucleic acids research2010;38;18;e173

    PUBMED: 20688953; PMC: 2952874; DOI: 10.1093/nar/gkq658

  • PARK2 deletions occur frequently in sporadic colorectal cancer and accelerate adenoma development in Apc mutant mice.

    Poulogiannis G, McIntyre RE, Dimitriadi M, Apps JR, Wilson CH, Ichimura K, Luo F, Cantley LC, Wyllie AH, Adams DJ and Arends MJ

    Proceedings of the National Academy of Sciences of the United States of America2010;107;34;15145-50

    PUBMED: 20696900; PMC: 2930574; DOI: 10.1073/pnas.1009941107

  • The activating mutation R201C in GNAS promotes intestinal tumourigenesis in Apc(Min/+) mice through activation of Wnt and ERK1/2 MAPK pathways.

    Wilson CH, McIntyre RE, Arends MJ and Adams DJ

    Oncogene2010;29;32;4567-75

    PUBMED: 20531296; PMC: 2923080; DOI: 10.1038/onc.2010.202

  • Using next-generation sequencing for high resolution multiplex analysis of copy number variation from nanogram quantities of DNA from formalin-fixed paraffin-embedded specimens.

    Wood HM, Belvedere O, Conway C, Daly C, Chalkley R, Bickerdike M, McKinley C, Egan P, Ross L, Hayward B, Morgan J, Davidson L, MacLennan K, Ong TK, Papagiannopoulos K, Cook I, Adams DJ, Taylor GR and Rabbitts P

    Nucleic acids research2010;38;14;e151

    PUBMED: 20525786; PMC: 2919738; DOI: 10.1093/nar/gkq510

  • CHD7 targets active gene enhancer elements to modulate ES cell-specific gene expression.

    Schnetz MP, Handoko L, Akhtar-Zaidi B, Bartels CF, Pereira CF, Fisher AG, Adams DJ, Flicek P, Crawford GE, Laframboise T, Tesar P, Wei CL and Scacheri PC

    PLoS genetics2010;6;7;e1001023

    PUBMED: 20657823; PMC: 2904778; DOI: 10.1371/journal.pgen.1001023

  • 53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers.

    Bouwman P, Aly A, Escandell JM, Pieterse M, Bartkova J, van der Gulden H, Hiddingh S, Thanasoula M, Kulkarni A, Yang Q, Haffty BG, Tommiska J, Blomqvist C, Drapkin R, Adams DJ, Nevanlinna H, Bartek J, Tarsounas M, Ganesan S and Jonkers J

    Nature structural & molecular biology2010;17;6;688-95

    PUBMED: 20453858; PMC: 2912507; DOI: 10.1038/nsmb.1831

  • Copy number variant detection in inbred strains from short read sequence data.

    Simpson JT, McIntyre RE, Adams DJ and Durbin R

    Bioinformatics (Oxford, England)2010;26;4;565-7

    PUBMED: 20022973; PMC: 2820678; DOI: 10.1093/bioinformatics/btp693

  • Novel candidate cancer genes identified by a large-scale cross-species comparative oncogenomics approach.

    Mattison J, Kool J, Uren AG, de Ridder J, Wessels L, Jonkers J, Bignell GR, Butler A, Rust AG, Brosch M, Wilson CH, van der Weyden L, Largaespada DA, Stratton MR, Futreal PA, van Lohuizen M, Berns A, Collier LS, Hubbard T and Adams DJ

    Cancer research2010;70;3;883-95

    PUBMED: 20103622; PMC: 2880710; DOI: 10.1158/0008-5472.CAN-09-1737

  • Genome-wide end-sequenced BAC resources for the NOD/MrkTac() and NOD/ShiLtJ() mouse genomes.

    Steward CA, Humphray S, Plumb B, Jones MC, Quail MA, Rice S, Cox T, Davies R, Bonfield J, Keane TM, Nefedov M, de Jong PJ, Lyons P, Wicker L, Todd J, Hayashizaki Y, Gulban O, Danska J, Harrow J, Hubbard T, Rogers J and Adams DJ

    Genomics2010;95;2;105-10

    PUBMED: 19909804; PMC: 2824108; DOI: 10.1016/j.ygeno.2009.10.004

  • Insertional mutagenesis in mice deficient for p15Ink4b, p16Ink4a, p21Cip1, and p27Kip1 reveals cancer gene interactions and correlations with tumor phenotypes.

    Kool J, Uren AG, Martins CP, Sie D, de Ridder J, Turner G, van Uitert M, Matentzoglu K, Lagcher W, Krimpenfort P, Gadiot J, Pritchard C, Lenz J, Lund AH, Jonkers J, Rogers J, Adams DJ, Wessels L, Berns A and van Lohuizen M

    Cancer research2010;70;2;520-31

    PUBMED: 20068150; PMC: 2875110; DOI: 10.1158/0008-5472.CAN-09-2736

  • A high-throughput pharmaceutical screen identifies compounds with specific toxicity against BRCA2-deficient tumors.

    Evers B, Schut E, van der Burg E, Braumuller TM, Egan DA, Holstege H, Edser P, Adams DJ, Wade-Martins R, Bouwman P and Jonkers J

    Clinical cancer research : an official journal of the American Association for Cancer Research2010;16;1;99-108

    PUBMED: 20008842; PMC: 2802735; DOI: 10.1158/1078-0432.CCR-09-2434

  • Identification of networks of co-occurring, tumor-related DNA copy number changes using a genome-wide scoring approach.

    Klijn C, Bot J, Adams DJ, Reinders M, Wessels L and Jonkers J

    PLoS computational biology2010;6;1;e1000631

    PUBMED: 20052266; PMC: 2791203; DOI: 10.1371/journal.pcbi.1000631

  • Ectodomains of the LDL receptor-related proteins LRP1b and LRP4 have anchorage independent functions in vivo.

    Dietrich MF, van der Weyden L, Prosser HM, Bradley A, Herz J and Adams DJ

    PloS one2010;5;4;e9960

    PUBMED: 20383322; PMC: 2850915; DOI: 10.1371/journal.pone.0009960

Publications 2009

  • The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus.

    Brass AL, Huang IC, Benita Y, John SP, Krishnan MN, Feeley EM, Ryan BJ, Weyer JL, van der Weyden L, Fikrig E, Adams DJ, Xavier RJ, Farzan M and Elledge SJ

    Cell2009;139;7;1243-54

    PUBMED: 20064371; PMC: 2824905; DOI: 10.1016/j.cell.2009.12.017

  • Discovery of candidate disease genes in ENU-induced mouse mutants by large-scale sequencing, including a splice-site mutation in nucleoredoxin.

    Boles MK, Wilkinson BM, Wilming LG, Liu B, Probst FJ, Harrow J, Grafham D, Hentges KE, Woodward LP, Maxwell A, Mitchell K, Risley MD, Johnson R, Hirschi K, Lupski JR, Funato Y, Miki H, Marin-Garcia P, Matthews L, Coffey AJ, Parker A, Hubbard TJ, Rogers J, Bradley A, Adams DJ and Justice MJ

    PLoS genetics2009;5;12;e1000759

    PUBMED: 20011118; PMC: 2782131; DOI: 10.1371/journal.pgen.1000759

  • Whole-body sleeping beauty mutagenesis can cause penetrant leukemia/lymphoma and rare high-grade glioma without associated embryonic lethality.

    Collier LS, Adams DJ, Hackett CS, Bendzick LE, Akagi K, Davies MN, Diers MD, Rodriguez FJ, Bender AM, Tieu C, Matise I, Dupuy AJ, Copeland NG, Jenkins NA, Hodgson JG, Weiss WA, Jenkins RB and Largaespada DA

    Cancer research2009;69;21;8429-37

    PUBMED: 19843846; PMC: 2771123; DOI: 10.1158/0008-5472.CAN-09-1760

  • Next-generation sequencing of vertebrate experimental organisms.

    Turner DJ, Keane TM, Sudbery I and Adams DJ

    Mammalian genome : official journal of the International Mammalian Genome Society2009;20;6;327-38

    PUBMED: 19452216; PMC: 2714443; DOI: 10.1007/s00335-009-9187-4

  • Megaoesophagus in Rassf1a-null mice.

    van der Weyden L, Happerfield L, Arends MJ and Adams DJ

    International journal of experimental pathology2009;90;2;101-8

    PUBMED: 19335548; PMC: 2676702; DOI: 10.1111/j.1365-2613.2008.00635.x

  • A high-throughput splinkerette-PCR method for the isolation and sequencing of retroviral insertion sites.

    Uren AG, Mikkers H, Kool J, van der Weyden L, Lund AH, Wilson CH, Rance R, Jonkers J, van Lohuizen M, Berns A and Adams DJ

    Nature protocols2009;4;5;789-98

    PUBMED: 19528954; DOI: 10.1038/nprot.2009.64

  • Deep short-read sequencing of chromosome 17 from the mouse strains A/J and CAST/Ei identifies significant germline variation and candidate genes that regulate liver triglyceride levels.

    Sudbery I, Stalker J, Simpson JT, Keane T, Rust AG, Hurles ME, Walter K, Lynch D, Teboul L, Brown SD, Li H, Ning Z, Nadeau JH, Croniger CM, Durbin R and Adams DJ

    Genome biology2009;10;10;R112

    PUBMED: 19825173; PMC: 2784327; DOI: 10.1186/gb-2009-10-10-r112

Older publications

  • Normal germ line establishment in mice carrying a deletion of the Ifitm/Fragilis gene family cluster.

    Lange UC, Adams DJ, Lee C, Barton S, Schneider R, Bradley A and Surani MA

    Molecular and cellular biology2008;28;15;4688-96

    PUBMED: 18505827; PMC: 2493357; DOI: 10.1128/MCB.00272-08

  • Loss of Rassf1a cooperates with Apc(Min) to accelerate intestinal tumourigenesis.

    van der Weyden L, Arends MJ, Dovey OM, Harrison HL, Lefebvre G, Conte N, Gergely FV, Bradley A and Adams DJ

    Oncogene 2008;27;32;4503-8

    PUBMED: 18391979; DOI: 10.1038/onc.2008.94

  • Large-scale mutagenesis in p19(ARF)- and p53-deficient mice identifies cancer genes and their collaborative networks.

    Uren AG, Kool J, Matentzoglu K, de Ridder J, Mattison J, van Uitert M, Lagcher W, Sie D, Tanger E, Cox T, Reinders M, Hubbard TJ, Rogers J, Jonkers J, Wessels L, Adams DJ, van Lohuizen M and Berns A

    Cell2008;133;4;727-41

    PUBMED: 18485879; PMC: 2405818; DOI: 10.1016/j.cell.2008.03.021

  • The Ras-association domain family (RASSF) members and their role in human tumourigenesis.

    van der Weyden L and Adams DJ

    Biochimica et biophysica acta2007;1776;1;58-85

    PUBMED: 17692468; PMC: 2586335; DOI: 10.1016/j.bbcan.2007.06.003

  • Renin enhancer is critical for control of renin gene expression and cardiovascular function.

    Adams DJ, Head GA, Markus MA, Lovicu FJ, van der Weyden L, Köntgen F, Arends MJ, Thiru S, Mayorov DN and Morris BJ

    The Journal of biological chemistry2006;281;42;31753-61

    PUBMED: 16895910; DOI: 10.1074/jbc.M605720200

  • Functional knockout of the matrilin-3 gene causes premature chondrocyte maturation to hypertrophy and increases bone mineral density and osteoarthritis.

    van der Weyden L, Wei L, Luo J, Yang X, Birk DE, Adams DJ, Bradley A and Chen Q

    The American journal of pathology2006;169;2;515-27

    PUBMED: 16877353; PMC: 1698783; DOI: 10.2353/ajpath.2006.050981

  • TranscriptSNPView: a genome-wide catalog of mouse coding variation.

    Cunningham F, Rios D, Griffiths M, Smith J, Ning Z, Cox T, Flicek P, Marin-Garcin P, Herrero J, Rogers J, van der Weyden L, Bradley A, Birney E and Adams DJ

    Nature genetics2006;38;8;853

    PUBMED: 16874317; PMC: 2610433; DOI: 10.1038/ng0806-853a

  • Geminin is essential to prevent endoreduplication and to form pluripotent cells during mammalian development.

    Gonzalez MA, Tachibana KE, Adams DJ, van der Weyden L, Hemberger M, Coleman N, Bradley A and Laskey RA

    Genes & development2006;20;14;1880-4

    PUBMED: 16847348; PMC: 1522086; DOI: 10.1101/gad.379706

  • Loss of TSLC1 causes male infertility due to a defect at the spermatid stage of spermatogenesis.

    van der Weyden L, Arends MJ, Chausiaux OE, Ellis PJ, Lange UC, Surani MA, Affara N, Murakami Y, Adams DJ and Bradley A

    Molecular and cellular biology2006;26;9;3595-609

    PUBMED: 16611999; PMC: 1447413; DOI: 10.1128/MCB.26.9.3595-3609.2006

  • DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

    Zody MC, Garber M, Adams DJ, Sharpe T, Harrow J, Lupski JR, Nicholson C, Searle SM, Wilming L, Young SK, Abouelleil A, Allen NR, Bi W, Bloom T, Borowsky ML, Bugalter BE, Butler J, Chang JL, Chen CK, Cook A, Corum B, Cuomo CA, de Jong PJ, DeCaprio D, Dewar K, FitzGerald M, Gilbert J, Gibson R, Gnerre S, Goldstein S, Grafham DV, Grocock R, Hafez N, Hagopian DS, Hart E, Norman CH, Humphray S, Jaffe DB, Jones M, Kamal M, Khodiyar VK, LaButti K, Laird G, Lehoczky J, Liu X, Lokyitsang T, Loveland J, Lui A, Macdonald P, Major JE, Matthews L, Mauceli E, McCarroll SA, Mihalev AH, Mudge J, Nguyen C, Nicol R, O'Leary SB, Osoegawa K, Schwartz DC, Shaw-Smith C, Stankiewicz P, Steward C, Swarbreck D, Venkataraman V, Whittaker CA, Yang X, Zimmer AR, Bradley A, Hubbard T, Birren BW, Rogers J, Lander ES and Nusbaum C

    Nature2006;440;7087;1045-9

    PUBMED: 16625196; PMC: 2610434; DOI: 10.1038/nature04689

[Wellcome Library, London]

David's Project
Experimental Cancer Genetics
Research Area
Mouse & Zebrafish
Email
da1@sanger.ac.uk
* quick link - http://q.sanger.ac.uk/cpn9kmhe