Honorary Faculty - Professor Chris Newbold

Professor Chris Newbold has collaborated with teams from the Sanger Institute since 1995, initially on the malaria genome project and latterly on comparative genomics, genome variation and functional genomics. He works most closely with the Parasite Genomics team under Matt Berriman and Dominic Kwiatkowski's group of the Malaria Programme.

Chris graduated with an MA and PhD from Cambridge University in 1978. After a postdoctoral fellowship in rodent malaria at The National Institute for Medical Research, Mill Hill, he moved to Oxford in 1984. Here he continued to work on rodent malaria with a particular interest in antigenic variation and soon moved to working on the same area in human malaria. He helped to establish the Wellcome Trust unit in Kilifi, Kenya and has worked closely with colleagues there ever since. He became a Professor in 1997 and leads the Molecular Parasitology Group at the Weatherall Institute of Molecular Medicine where he continues to work on mechanisms of disease and immune evasion in malaria.

Selected Publications

  • The genome of the simian and human malaria parasite Plasmodium knowlesi.

    Pain A, Böhme U, Berry AE, Mungall K, Finn RD, Jackson AP, Mourier T, Mistry J, Pasini EM, Aslett MA, Balasubrammaniam S, Borgwardt K, Brooks K, Carret C, Carver TJ, Cherevach I, Chillingworth T, Clark TG, Galinski MR, Hall N, Harper D, Harris D, Hauser H, Ivens A, Janssen CS, Keane T, Larke N, Lapp S, Marti M, Moule S, Meyer IM, Ormond D, Peters N, Sanders M, Sanders S, Sargeant TJ, Simmonds M, Smith F, Squares R, Thurston S, Tivey AR, Walker D, White B, Zuiderwijk E, Churcher C, Quail MA, Cowman AF, Turner CM, Rajandream MA, Kocken CH, Thomas AW, Newbold CI, Barrell BG and Berriman M

    Nature 2008;455;7214;799-803

    PUBMED: 18843368; PMC: 2656934; DOI: 10.1038/nature07306

  • Plasmodium falciparum variant surface antigen expression patterns during malaria.

    Bull PC, Berriman M, Kyes S, Quail MA, Hall N, Kortok MM, Marsh K and Newbold CI

    PLoS pathogens 2005;1;3;e26

    PUBMED: 16304608; PMC: 1287908; DOI: 10.1371/journal.ppat.0010026

  • Variable var transition rates underlie antigenic variation in malaria.

    Horrocks P, Pinches R, Christodoulou Z, Kyes SA and Newbold CI

    Proceedings of the National Academy of Sciences of the United States of America 2004;101;30;11129-34

    PUBMED: 15256597; PMC: 503751; DOI: 10.1073/pnas.0402347101

  • Genome sequence of the human malaria parasite Plasmodium falciparum.

    Gardner MJ, Hall N, Fung E, White O, Berriman M, Hyman RW, Carlton JM, Pain A, Nelson KE, Bowman S, Paulsen IT, James K, Eisen JA, Rutherford K, Salzberg SL, Craig A, Kyes S, Chan MS, Nene V, Shallom SJ, Suh B, Peterson J, Angiuoli S, Pertea M, Allen J, Selengut J, Haft D, Mather MW, Vaidya AB, Martin DM, Fairlamb AH, Fraunholz MJ, Roos DS, Ralph SA, McFadden GI, Cummings LM, Subramanian GM, Mungall C, Venter JC, Carucci DJ, Hoffman SL, Newbold C, Davis RW, Fraser CM and Barrell B

    Nature 2002;419;6906;498-511

    PUBMED: 12368864; DOI: 10.1038/nature01097

  • Immunity to non-cerebral severe malaria is acquired after one or two infections.

    Gupta S, Snow RW, Donnelly CA, Marsh K and Newbold C

    Nature medicine 1999;5;3;340-3

    PUBMED: 10086393; DOI: 10.1038/6560

  • Rapid switching to multiple antigenic and adhesive phenotypes in malaria.

    Roberts DJ, Craig AG, Berendt AR, Pinches R, Nash G, Marsh K and Newbold CI

    Nature 1992;357;6380;689-92

    PUBMED: 1614515; DOI: 10.1038/357689a0

* quick link - http://q.sanger.ac.uk/fd6umpwh