Dr Carl Anderson

Carl applies statistical methodology to the analysis of large-scale genetic data sets in a bid to better understand the causes of several common human diseases. To date, his research has focussed heavily on the design, analysis and interpretation of genome-wide association studies. He has taken a lead a role in the identification of almost 40 risk loci for inflammatory bowel diseases (IBD).

Carl graduated from the University of Sheffield in 2001 with a BSc in Biomedical Sciences and successfully completed an MSc in Genetic Epidemiology in 2002 (also at the University Sheffield), In 2006 he earned his PhD from the University of Edinburgh under the supervision of Professor Peter Visscher (during which time he spent two years based at Queensland Institute of Medical Research, Australia). In 2007 he took up a postdoctoral position at the Wellcome Trust Centre for Human Genetics, Oxford where he worked on the IBD arm of the Wellcome Trust Case Control Consortium (WTCCC) study. In September 2009 Carl started a Career Development Fellowship Group Leader post at the Wellcome Trust Sanger Institute. Carl’s group apply statistical and computational techniques to large-scale genetic data sets in an effort to identify genomic regions underlying susceptibility to common human diseases.

Selected Publications

• Investigation of Crohn's disease risk loci in ulcerative colitis further defines their molecular relationship.

  Anderson CA, Massey DC, Barrett JC, Prescott NJ, Tremelling M, Fisher SA, Gwilliam R, Jacob J, Nimmo ER, Drummond H, Lees CW, Onnie CM, Hanson C, Blaszczyk K, Ravindrarajah R, Hunt S, Varma D, Hammond N, Lewis G, Attlesey H, Watkins N, Ouwehand W, Strachan D, McArdle W, Lewis CM, Wellcome Trust Case Control Consortium, Lobo A, Sanderson J, Jewell DP, Deloukas P, Mansfield JC, Mathew CG, Satsangi J and Parkes M

  Gastroenterology 2009;136;2;523-9.e3

  PUBMED: 19068216; DOI: 10.1053/j.gastro.2008.10.032; PMC: 2675137

• Evaluating the effects of imputation on the power, coverage, and cost efficiency of genome-wide SNP platforms.

  Anderson CA, Pettersson FH, Barrett JC, Zhuang JJ, Ragoussis J, Cardon LR and Morris AP

  American journal of human genetics 2008;83;1;112-9

  PUBMED: 18589396; DOI: 10.1016/j.ajhg.2008.06.008; PMC: 2443836

• Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.

  Barrett JC, Hansoul S, Nicolae DL, Cho JH, Duerr RH, Rioux JD, Brant SR, Silverberg MS, Taylor KD, Barmada MM, Bitton A, Dassopoulos T, Datta LW, Green T, Griffiths AM, Kistner EO, Murtha MT, Regueiro MD, Rotter JI, Schumm LP, Steinhart AH, Targan SR, Xavier RJ, NIDDK IBD Genetics Consortium, Libioulle C, Sandor C, Lathrop M, Belaiche J, Dewit O, Gut I, Heath S, Laukens D, Mni M, Rutgeerts P, Van Gossum A, Zelenika D, Franchimont D, Hugot JP, de Vos M, Vermeire S, Louis E, Belgian-French IBD Consortium, Wellcome Trust Case Control Consortium, Cardon LR, Anderson CA, Drummond H, Nimmo E, Ahmad T, Prescott NJ, Onnie CM, Fisher SA, Marchini J, Ghori J, Bumpstead S, Gwilliam R, Tremelling M, Deloukas P, Mansfield J, Jewell D, Satsangi J, Mathew CG, Parkes M, Georges M and Daly MJ

  Nature genetics 2008;40;8;955-62

  PUBMED: 18587394; DOI: 10.1038/ng.175; PMC: 2574810

• Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease.

  Fisher SA, Tremelling M, Anderson CA, Gwilliam R, Bumpstead S, Prescott NJ, Nimmo ER, Massey D, Berzuini C, Johnson C, Barrett JC, Cummings FR, Drummond H, Lees CW, Onnie CM, Hanson CE, Blaszczyk K, Inouye M, Ewels P, Ravindrarajah R, Keniry A, Hunt S, Carter M, Watkins N, Ouwehand W, Lewis CM, Cardon L, Wellcome Trust Case Control Consortium, Lobo A, Forbes A, Sanderson J, Jewell DP, Mansfield JC, Deloukas P, Mathew CG, Parkes M and Satsangi J

  Nature genetics 2008;40;6;710-2

  PUBMED: 18438406; DOI: 10.1038/ng.145; PMC: 2719289

• Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility.

  Parkes M, Barrett JC, Prescott NJ, Tremelling M, Anderson CA, Fisher SA, Roberts RG, Nimmo ER, Cummings FR, Soars D, Drummond H, Lees CW, Khawaja SA, Bagnall R, Burke DA, Todhunter CE, Ahmad T, Onnie CM, McArdle W, Strachan D, Bethel G, Bryan C, Lewis CM, Deloukas P, Forbes A, Sanderson J, Jewell DP, Satsangi J, Mansfield JC, Wellcome Trust Case Control Consortium, Cardon L and Mathew CG

  Nature genetics 2007;39;7;830-2

  PUBMED: 17554261; DOI: 10.1038/ng2061; PMC: 2628541