Dr Carl Anderson

Carl applies statistical methodology to the analysis of large-scale genetic data sets in a bid to better understand the causes of several common human diseases. To date, his research has focussed heavily on the design, analysis and interpretation of genome-wide association studies. He has taken a lead a role in the identification of almost 100 risk loci for inflammatory bowel diseases (IBD).

Carl graduated from the University of Sheffield in 2001 with a BSc in Biomedical Sciences and successfully completed an MSc in Genetic Epidemiology in 2002 (also at the University Sheffield), In 2006 he earned his PhD from the University of Edinburgh under the supervision of Professor Peter Visscher (during which time he spent two years based at Queensland Institute of Medical Research, Australia). In 2007 he took up a postdoctoral position at the Wellcome Trust Centre for Human Genetics, Oxford where he worked on the IBD arm of the Wellcome Trust Case Control Consortium (WTCCC) study. In September 2009 Carl started a Career Development Fellowship Group Leader post at the Wellcome Trust Sanger Institute. Carl's group apply statistical and computational techniques to large-scale genetic data sets in an effort to identify genomic regions underlying susceptibility to common human diseases, with a particular focus on autoimmune-related diseases.

Selected Publications

• Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis.

  Liu JZ, Hov JR, Folseraas T, Ellinghaus E, Rushbrook SM, Doncheva NT, Andreassen OA, Weersma RK, Weismüller TJ, Eksteen B, Invernizzi P, Hirschfield GM, Gotthardt DN, Pares A, Ellinghaus D, Shah T, Juran BD, Milkiewicz P, Rust C, Schramm C, Müller T, Srivastava B, Dalekos G, Nöthen MM, Herms S, Winkelmann J, Mitrovic M, Braun F, Ponsioen CY, Croucher PJ, Sterneck M, Teufel A, Mason AL, Saarela J, Leppa V, Dorfman R, Alvaro D, Floreani A, Onengut-Gumuscu S, Rich SS, Thompson WK, Schork AJ, Næss S, Thomsen I, Mayr G, König IR, Hveem K, Cleynen I, Gutierrez-Achury J, Ricaño-Ponce I, van Heel D, Björnsson E, Sandford RN, Durie PR, Melum E, Vatn MH, Silverberg MS, Duerr RH, Padyukov L, Brand S, Sans M, Annese V, Achkar JP, Boberg KM, Marschall HU, Chazouillères O, Bowlus CL, Wijmenga C, Schrumpf E, Vermeire S, Albrecht M, UK-PSCSC Consortium, International IBD Genetics Consortium, Rioux JD, Alexander G, Bergquist A, Cho J, Schreiber S, Manns MP, Färkkilä M, Dale AM, Chapman RW, Lazaridis KN, International PSC Study Group, Franke A, Anderson CA and Karlsen TH

  Nature genetics 2013;45;6;670-5

  PUBMED: 23603763; PMC: 3667736; DOI: 10.1038/ng.2616

• Dense fine-mapping study identifies new susceptibility loci for primary biliary cirrhosis.

  Liu JZ, Almarri MA, Gaffney DJ, Mells GF, Jostins L, Cordell HJ, Ducker SJ, Day DB, Heneghan MA, Neuberger JM, Donaldson PT, Bathgate AJ, Burroughs A, Davies MH, Jones DE, Alexander GJ, Barrett JC, Sandford RN, Anderson CA, UK Primary Biliary Cirrhosis (PBC) Consortium and Wellcome Trust Case Control Consortium 3

  Nature genetics 2012;44;10;1137-41

  PUBMED: 22961000; PMC: 3459817; DOI: 10.1038/ng.2395

• Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis.

  Mells GF, Floyd JA, Morley KI, Cordell HJ, Franklin CS, Shin SY, Heneghan MA, Neuberger JM, Donaldson PT, Day DB, Ducker SJ, Muriithi AW, Wheater EF, Hammond CJ, Dawwas MF, UK PBC Consortium, Wellcome Trust Case Control Consortium 3, Jones DE, Peltonen L, Alexander GJ, Sandford RN and Anderson CA

  Nature genetics 2011;43;4;329-32

  PUBMED: 21399635; PMC: 3071550; DOI: 10.1038/ng.789

• Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.

  Anderson CA, Boucher G, Lees CW, Franke A, D'Amato M, Taylor KD, Lee JC, Goyette P, Imielinski M, Latiano A, Lagacé C, Scott R, Amininejad L, Bumpstead S, Baidoo L, Baldassano RN, Barclay M, Bayless TM, Brand S, Büning C, Colombel JF, Denson LA, De Vos M, Dubinsky M, Edwards C, Ellinghaus D, Fehrmann RS, Floyd JA, Florin T, Franchimont D, Franke L, Georges M, Glas J, Glazer NL, Guthery SL, Haritunians T, Hayward NK, Hugot JP, Jobin G, Laukens D, Lawrance I, Lémann M, Levine A, Libioulle C, Louis E, McGovern DP, Milla M, Montgomery GW, Morley KI, Mowat C, Ng A, Newman W, Ophoff RA, Papi L, Palmieri O, Peyrin-Biroulet L, Panés J, Phillips A, Prescott NJ, Proctor DD, Roberts R, Russell R, Rutgeerts P, Sanderson J, Sans M, Schumm P, Seibold F, Sharma Y, Simms LA, Seielstad M, Steinhart AH, Targan SR, van den Berg LH, Vatn M, Verspaget H, Walters T, Wijmenga C, Wilson DC, Westra HJ, Xavier RJ, Zhao ZZ, Ponsioen CY, Andersen V, Torkvist L, Gazouli M, Anagnou NP, Karlsen TH, Kupcinskas L, Sventoraityte J, Mansfield JC, Kugathasan S, Silverberg MS, Halfvarson J, Rotter JI, Mathew CG, Griffiths AM, Gearry R, Ahmad T, Brant SR, Chamaillard M, Satsangi J, Cho JH, Schreiber S, Daly MJ, Barrett JC, Parkes M, Annese V, Hakonarson H, Radford-Smith G, Duerr RH, Vermeire S, Weersma RK and Rioux JD

  Nature genetics 2011;43;3;246-52

  PUBMED: 21297633; PMC: 3084597; DOI: 10.1038/ng.764

• Genome-wide association study identifies a locus at 7p15.2 associated with endometriosis.

  Painter JN, Anderson CA, Nyholt DR, Macgregor S, Lin J, Lee SH, Lambert A, Zhao ZZ, Roseman F, Guo Q, Gordon SD, Wallace L, Henders AK, Visscher PM, Kraft P, Martin NG, Morris AP, Treloar SA, Kennedy SH, Missmer SA, Montgomery GW and Zondervan KT

  Nature genetics 2011;43;1;51-4

  PUBMED: 21151130; PMC: 3019124; DOI: 10.1038/ng.731

• Synthetic associations are unlikely to account for many common disease genome-wide association signals.

  Anderson CA, Soranzo N, Zeggini E and Barrett JC

  PLoS biology 2011;9;1;e1000580

  PUBMED: 21267062; PMC: 3022527; DOI: 10.1371/journal.pbio.1000580

• Evaluating the effects of imputation on the power, coverage, and cost efficiency of genome-wide SNP platforms.

  Anderson CA, Pettersson FH, Barrett JC, Zhuang JJ, Ragoussis J, Cardon LR and Morris AP

  American journal of human genetics 2008;83;1;112-9

  PUBMED: 18589396; PMC: 2443836; DOI: 10.1016/j.ajhg.2008.06.008