Honorary Faculty - Dr Andy Futreal

Andy Futreal is Professor of Genomic Medicine at University of Texas MD Anderson Cancer Center. Before accepting this position, from 2002 to 2012, Andy was joint head of the Cancer Genome Project with Professor Mike Stratton, and became head of Cancer Genetics and Genomics at the Sanger Institute in 2011. Andy is collaborating with the Institute to investigate the molecular genetics of cancer and identify of cancer-causing genes.

Before joining the Sanger Institute in 2002, Andy's work was most heavily focused on identification of susceptibility genes for breast and ovarian cancers and on characterising somatic genetic alterations in breast cancer and gynaecologic malignancies. After his arrival, Andy worked closely with Mike Stratton within Cancer Genome Project, and he was instrumental in identifying somatic mutations in human cancer via large-scale genomic approaches. His Institute-based research also encompassed the application of molecular genetics to potential elucidation of therapeutic targets in cancer, the potential role of somatic genetics in patient stratification to conventional cancer therapies and the functional investigation of mutations identified in the Cancer Genome Project.

Selected Publications

• Mutations in ZDHHC9, which encodes a palmitoyltransferase of NRAS and HRAS, cause X-linked mental retardation associated with a Marfanoid habitus.

  Raymond FL, Tarpey PS, Edkins S, Tofts C, O'Meara S, Teague J, Butler A, Stevens C, Barthorpe S, Buck G, Cole J, Dicks E, Gray K, Halliday K, Hills K, Hinton J, Jones D, Menzies A, Perry J, Raine K, Shepherd R, Small A, Varian J, Widaa S, Mallya U, Moon J, Luo Y, Shaw M, Boyle J, Kerr B, Turner G, Quarrell O, Cole T, Easton DF, Wooster R, Bobrow M, Schwartz CE, Gecz J, Stratton MR and Futreal PA

  American journal of human genetics 2007;80;5;982-7

  PUBMED: 17436253; PMC: 1852737; DOI: 10.1086/513609

• Patterns of somatic mutation in human cancer genomes.

  Greenman C, Stephens P, Smith R, Dalgliesh GL, Hunter C, Bignell G, Davies H, Teague J, Butler A, Stevens C, Edkins S, O'Meara S, Vastrik I, Schmidt EE, Avis T, Barthorpe S, Bhamra G, Buck G, Choudhury B, Clements J, Cole J, Dicks E, Forbes S, Gray K, Halliday K, Harrison R, Hills K, Hinton J, Jenkinson A, Jones D, Menzies A, Mironenko T, Perry J, Raine K, Richardson D, Shepherd R, Small A, Tofts C, Varian J, Webb T, West S, Widaa S, Yates A, Cahill DP, Louis DN, Goldstraw P, Nicholson AG, Brasseur F, Looijenga L, Weber BL, Chiew YE, DeFazio A, Greaves MF, Green AR, Campbell P, Birney E, Easton DF, Chenevix-Trench G, Tan MH, Khoo SK, Teh BT, Yuen ST, Leung SY, Wooster R, Futreal PA and Stratton MR

  Nature 2007;446;7132;153-8

  PUBMED: 17344846; PMC: 2712719; DOI: 10.1038/nature05610

• A hypermutation phenotype and somatic MSH6 mutations in recurrent human malignant gliomas after alkylator chemotherapy.

  Hunter C, Smith R, Cahill DP, Stephens P, Stevens C, Teague J, Greenman C, Edkins S, Bignell G, Davies H, O'Meara S, Parker A, Avis T, Barthorpe S, Brackenbury L, Buck G, Butler A, Clements J, Cole J, Dicks E, Forbes S, Gorton M, Gray K, Halliday K, Harrison R, Hills K, Hinton J, Jenkinson A, Jones D, Kosmidou V, Laman R, Lugg R, Menzies A, Perry J, Petty R, Raine K, Richardson D, Shepherd R, Small A, Solomon H, Tofts C, Varian J, West S, Widaa S, Yates A, Easton DF, Riggins G, Roy JE, Levine KK, Mueller W, Batchelor TT, Louis DN, Stratton MR, Futreal PA and Wooster R

  Cancer research 2006;66;8;3987-91

  PUBMED: 16618716; DOI: 10.1158/0008-5472.CAN-06-0127

• Somatic mutations of the protein kinase gene family in human lung cancer.

  Davies H, Hunter C, Smith R, Stephens P, Greenman C, Bignell G, Teague J, Butler A, Edkins S, Stevens C, Parker A, O'Meara S, Avis T, Barthorpe S, Brackenbury L, Buck G, Clements J, Cole J, Dicks E, Edwards K, Forbes S, Gorton M, Gray K, Halliday K, Harrison R, Hills K, Hinton J, Jones D, Kosmidou V, Laman R, Lugg R, Menzies A, Perry J, Petty R, Raine K, Shepherd R, Small A, Solomon H, Stephens Y, Tofts C, Varian J, Webb A, West S, Widaa S, Yates A, Brasseur F, Cooper CS, Flanagan AM, Green A, Knowles M, Leung SY, Looijenga LH, Malkowicz B, Pierotti MA, Teh BT, Yuen ST, Lakhani SR, Easton DF, Weber BL, Goldstraw P, Nicholson AG, Wooster R, Stratton MR and Futreal PA

  Cancer research 2005;65;17;7591-5

  PUBMED: 16140923; DOI: 10.1158/0008-5472.CAN-05-1855

• Mutations of the BRAF gene in human cancer.

  Davies H, Bignell GR, Cox C, Stephens P, Edkins S, Clegg S, Teague J, Woffendin H, Garnett MJ, Bottomley W, Davis N, Dicks E, Ewing R, Floyd Y, Gray K, Hall S, Hawes R, Hughes J, Kosmidou V, Menzies A, Mould C, Parker A, Stevens C, Watt S, Hooper S, Wilson R, Jayatilake H, Gusterson BA, Cooper C, Shipley J, Hargrave D, Pritchard-Jones K, Maitland N, Chenevix-Trench G, Riggins GJ, Bigner DD, Palmieri G, Cossu A, Flanagan A, Nicholson A, Ho JW, Leung SY, Yuen ST, Weber BL, Seigler HF, Darrow TL, Paterson H, Marais R, Marshall CJ, Wooster R, Stratton MR and Futreal PA

  Nature 2002;417;6892;949-54

  PUBMED: 12068308; DOI: 10.1038/nature00766

Related links:

• University of Texas MD Anderson Cancer Center