Wellcome Trust International Fellow - Dr Abdoulaye Djimdé

Abdoulaye Djimdé is a leading malaria researcher based in Mali, working primarily on the genetic epidemiology of antimalarial drug resistance in West Africa. He is committed to building research capacity in Africa and has been instrumental in the formation of networks and partnerships collaboratively investigating malaria and drug resistance in the region.

Djimdé is an Associate Professor of Microbiology and Immunology and Chief of the Molecular Epidemiology and Drug Resistance Unit at the Malaria Research and Training Centre University of Bamako, Mali. There he leads a dynamic research group whose primary focus is to understand how variations in the genomes of the malaria parasite, the human host, and the mosquito vector relate to disease outcomes like the spread of antimalarial drug resistance. His translational research programme uses molecular and genetic approaches to tackle important problems in malaria control.

After receiving a pharmacy doctorate in 1988 from the University of Bamako, Mali, Djimdé started a private pharmacy and learnt first hand about the huge need for more effective ways of treating and preventing malaria. He began volunteering as a research assistant with Prof. Ogobara Doumbo at the Malaria Research and Training Centre in Bamako, and decided to undertake a graduate PhD training programme under two outstanding malaria researchers from the United States: Prof. Christopher V. Plowe at the University of Maryland and Dr. Thomas E. Wellems at the National Institutes of Health. During this time, Djimdé authored a number of notable papers that were published in the New England Journal of Medicine and the Lancet, describing the first reliable molecular marker for chloroquine-resistant malaria and a model for using molecular markers to monitor drug resistant malaria in the field.

As a strong proponent of capacity building for African research and collaborative research networks, Djimdé is also involved in good citizenship within the African research community. He was instrumental in the formation of the Worldwide Antimalarial Drug Resistance Network, on whose Scientific Advisory Board he serves. He worked to promote enhanced competitiveness, research priority and research capacity for African institutions during his time as Chair of the Multilateral Initiative on Malaria Task Force within the World Health Organization Tropical Disease Research Programme, where he helped to manage the process for awarding research grants in Africa. Currently he serves as coordinator of the West African Network for Clinical Trials of Antimalarial Drugs, with funding from the European and Developing Countries Clinical Trials Partnership to conduct multicentre phase III studies in Mali, Burkina Faso and Guinea.

Djimdé has won a number of prestigious awards during his career, including:

  • Chevalier de l'Ordre National from the Government of Mali, presented by the President of Mali in 2001
  • Fighting Malaria Prize from the Federation of the European Societies for Tropical Medicine and International Health in 2002
  • Senior Fellowship from the European and Developing Countries Clinical Trials Partnership in 2004
  • International Scholar of the Howard Hughes Medical Institute in 2005
  • Prix de la Pharmacie Francophone from the National Academy of Pharmacy of France in 2009

Selected Publications

  • Characterization of within-host Plasmodium falciparum diversity using next-generation sequence data.

    Auburn S, Campino S, Miotto O, Djimde AA, Zongo I, Manske M, Maslen G, Mangano V, Alcock D, MacInnis B, Rockett KA, Clark TG, Doumbo OK, Ouédraogo JB and Kwiatkowski DP

    PloS one 2012;7;2;e32891

  • An effective method to purify Plasmodium falciparum DNA directly from clinical blood samples for whole genome high-throughput sequencing.

    Auburn S, Campino S, Clark TG, Djimde AA, Zongo I, Pinches R, Manske M, Mangano V, Alcock D, Anastasi E, Maslen G, Macinnis B, Rockett K, Modiano D, Newbold CI, Doumbo OK, Ouédraogo JB and Kwiatkowski DP

    PloS one 2011;6;7;e22213

  • Effects of amodiaquine and artesunate on sulphadoxine-pyrimethamine pharmacokinetic parameters in children under five in Mali.

    Tekete MM, Toure S, Fredericks A, Beavogui AH, Sangare CP, Evans A, Smith P, Maiga H, Traore ZI, Doumbo OK, Barnes KI and Djimde AA

    Malaria journal 2011;10;275

  • A research agenda for malaria eradication: basic science and enabling technologies.

    malERA Consultative Group on Basic Science and Enabling Technologies

    PLoS medicine 2011;8;1;e1000399

  • Adaptive differentiation of Plasmodium falciparum populations inferred from single-nucleotide polymorphisms (SNPs) conferring drug resistance and from neutral SNPs.

    Maïga-Ascofaré O, Le Bras J, Mazmouz R, Renard E, Falcão S, Broussier E, Bustos D, Randrianarivelojosia M, Omar SA, Aubouy A, Lepère JF, Jean-François V, Djimdé AA and Clain J

    The Journal of infectious diseases 2010;202;7;1095-103

  • Sulfadoxine-pyrimethamine impairs Plasmodium falciparum gametocyte infectivity and Anopheles mosquito survival.

    Kone A, van de Vegte-Bolmer M, Siebelink-Stoter R, van Gemert GJ, Dara A, Niangaly H, Luty A, Doumbo OK, Sauerwein R and Djimde AA

    International journal for parasitology 2010;40;10;1221-8

  • A molecular map of chloroquine resistance in Mali.

    Djimde AA, Barger B, Kone A, Beavogui AH, Tekete M, Fofana B, Dara A, Maiga H, Dembele D, Toure S, Dama S, Ouologuem D, Sangare CP, Dolo A, Sogoba N, Nimaga K, Kone Y and Doumbo OK

    FEMS immunology and medical microbiology 2010;58;1;113-8

  • Genome-wide and fine-resolution association analysis of malaria in West Africa.

    Jallow M, Teo YY, Small KS, Rockett KA, Deloukas P, Clark TG, Kivinen K, Bojang KA, Conway DJ, Pinder M, Sirugo G, Sisay-Joof F, Usen S, Auburn S, Bumpstead SJ, Campino S, Coffey A, Dunham A, Fry AE, Green A, Gwilliam R, Hunt SE, Inouye M, Jeffreys AE, Mendy A, Palotie A, Potter S, Ragoussis J, Rogers J, Rowlands K, Somaskantharajah E, Whittaker P, Widden C, Donnelly P, Howie B, Marchini J, Morris A, SanJoaquin M, Achidi EA, Agbenyega T, Allen A, Amodu O, Corran P, Djimde A, Dolo A, Doumbo OK, Drakeley C, Dunstan S, Evans J, Farrar J, Fernando D, Hien TT, Horstmann RD, Ibrahim M, Karunaweera N, Kokwaro G, Koram KA, Lemnge M, Makani J, Marsh K, Michon P, Modiano D, Molyneux ME, Mueller I, Parker M, Peshu N, Plowe CV, Puijalon O, Reeder J, Reyburn H, Riley EM, Sakuntabhai A, Singhasivanon P, Sirima S, Tall A, Taylor TE, Thera M, Troye-Blomberg M, Williams TN, Wilson M, Kwiatkowski DP, Wellcome Trust Case Control Consortium and Malaria Genomic Epidemiology Network

    Nature genetics 2009;41;6;657-65

  • Molecular diagnosis of resistance to antimalarial drugs during epidemics and in war zones.

    Djimdé AA, Dolo A, Ouattara A, Diakité S, Plowe CV and Doumbo OK

    The Journal of infectious diseases 2004;190;4;853-5

  • Clearance of drug-resistant parasites as a model for protective immunity in Plasmodium falciparum malaria.

    Djimdé AA, Doumbo OK, Traore O, Guindo AB, Kayentao K, Diourte Y, Niare-Doumbo S, Coulibaly D, Kone AK, Cissoko Y, Tekete M, Fofana B, Dicko A, Diallo DA, Wellems TE, Kwiatkowski D and Plowe CV

    The American journal of tropical medicine and hygiene 2003;69;5;558-63

  • Application of a molecular marker for surveillance of chloroquine-resistant falciparum malaria.

    Djimdé A, Doumbo OK, Steketee RW and Plowe CV

    Lancet 2001;358;9285;890-1

  • A molecular marker for chloroquine-resistant falciparum malaria.

    Djimdé A, Doumbo OK, Cortese JF, Kayentao K, Doumbo S, Diourté Y, Coulibaly D, Dicko A, Su XZ, Nomura T, Fidock DA, Wellems TE and Plowe CV

    The New England journal of medicine 2001;344;4;257-63

[Genome Research Limited]

Project
Malaria Programme
Email
ad15@sanger.ac.uk

Related links

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