Honorary Faculty - Dr Ana Cvejic

Dr Ana Cvejic is Cancer Research UK Career Development Fellow at the Department of Haematology, University of Cambridge. Her group focuses on normal and malignant blood cell development by characterising the function of novel genes that have been identified by exome sequencing and genome-wide association studies. Ana works in collaboration with Sanger Institute Faculty Derek Stemple, Nicole Soranzo and Peter Campbell.

During her PhD at the University of Bristol, Ana collaborated with Derek Stemple on searching for the disruptive mutant alleles of the wasp gene. Later she characterised the gene's function carefully and showed its role in the directed migration of neutrophil blood cells to sites of wounding. Following this successful collaboration, Ana has been working closely with Nicole Soranzo's group to verify the functional importance of a number of genes identified by a genome-wide association study in determining platelet size and number. In addition, she has worked with Peter Campbell to validate newly identified myeloid cancer genes and she is continuing her long-lasting collaboration with Derek Stemple.

In 2008 Ana received her PhD in Biochemistry at the University of Bristol. She then moved to University of Cambridge/Wellcome Trust Sanger Institute to start a Postdoctoral Fellowship, with Professor Willem Ouwehand and Dr Derek Stemple. Ana worked on a collaborative project to examine the role of several genes in thrombocyte (the zebrafish equivalent to platelets) development and function in zebrafish. Over the next four years, Ana independently established haematopoiesis research using the zebrafish model at the Sanger Institute. In 2012 Ana was awarded a Cancer Research UK Career Development Fellowship and became a Principal Investigator at the Department of Haematology, University of Cambridge.

Selected Publications

  • SMIM1 underlies the Vel blood group and influences red blood cell traits.

    Cvejic A, Haer-Wigman L, Stephens JC, Kostadima M, Smethurst PA, Frontini M, van den Akker E, Bertone P, Bielczyk-Maczyńska E, Farrow S, Fehrmann RS, Gray A, de Haas M, Haver VG, Jordan G, Karjalainen J, Kerstens HH, Kiddle G, Lloyd-Jones H, Needs M, Poole J, Soussan AA, Rendon A, Rieneck K, Sambrook JG, Schepers H, Silljé HH, Sipos B, Swinkels D, Tamuri AU, Verweij N, Watkins NA, Westra HJ, Stemple D, Franke L, Soranzo N, Stunnenberg HG, Goldman N, van der Harst P, van der Schoot CE, Ouwehand WH and Albers CA

    Nature genetics 2013;45;5;542-5

  • New gene functions in megakaryopoiesis and platelet formation.

    Gieger C, Radhakrishnan A, Cvejic A, Tang W, Porcu E, Pistis G, Serbanovic-Canic J, Elling U, Goodall AH, Labrune Y, Lopez LM, Mägi R, Meacham S, Okada Y, Pirastu N, Sorice R, Teumer A, Voss K, Zhang W, Ramirez-Solis R, Bis JC, Ellinghaus D, Gögele M, Hottenga JJ, Langenberg C, Kovacs P, O'Reilly PF, Shin SY, Esko T, Hartiala J, Kanoni S, Murgia F, Parsa A, Stephens J, van der Harst P, Ellen van der Schoot C, Allayee H, Attwood A, Balkau B, Bastardot F, Basu S, Baumeister SE, Biino G, Bomba L, Bonnefond A, Cambien F, Chambers JC, Cucca F, D'Adamo P, Davies G, de Boer RA, de Geus EJ, Döring A, Elliott P, Erdmann J, Evans DM, Falchi M, Feng W, Folsom AR, Frazer IH, Gibson QD, Glazer NL, Hammond C, Hartikainen AL, Heckbert SR, Hengstenberg C, Hersch M, Illig T, Loos RJ, Jolley J, Khaw KT, Kühnel B, Kyrtsonis MC, Lagou V, Lloyd-Jones H, Lumley T, Mangino M, Maschio A, Mateo Leach I, McKnight B, Memari Y, Mitchell BD, Montgomery GW, Nakamura Y, Nauck M, Navis G, Nöthlings U, Nolte IM, Porteous DJ, Pouta A, Pramstaller PP, Pullat J, Ring SM, Rotter JI, Ruggiero D, Ruokonen A, Sala C, Samani NJ, Sambrook J, Schlessinger D, Schreiber S, Schunkert H, Scott J, Smith NL, Snieder H, Starr JM, Stumvoll M, Takahashi A, Tang WH, Taylor K, Tenesa A, Lay Thein S, Tönjes A, Uda M, Ulivi S, van Veldhuisen DJ, Visscher PM, Völker U, Wichmann HE, Wiggins KL, Willemsen G, Yang TP, Hua Zhao J, Zitting P, Bradley JR, Dedoussis GV, Gasparini P, Hazen SL, Metspalu A, Pirastu M, Shuldiner AR, Joost van Pelt L, Zwaginga JJ, Boomsma DI, Deary IJ, Franke A, Froguel P, Ganesh SK, Jarvelin MR, Martin NG, Meisinger C, Psaty BM, Spector TD, Wareham NJ, Akkerman JW, Ciullo M, Deloukas P, Greinacher A, Jupe S, Kamatani N, Khadake J, Kooner JS, Penninger J, Prokopenko I, Stemple D, Toniolo D, Wernisch L, Sanna S, Hicks AA, Rendon A, Ferreira MA, Ouwehand WH and Soranzo N

    Nature 2011;480;7376;201-8

  • Silencing of RhoA nucleotide exchange factor, ARHGEF3, reveals its unexpected role in iron uptake.

    Serbanovic-Canic J, Cvejic A, Soranzo N, Stemple DL, Ouwehand WH and Freson K

    Blood 2011;118;18;4967-76

  • Exome sequencing identifies NBEAL2 as the causative gene for gray platelet syndrome.

    Albers CA, Cvejic A, Favier R, Bouwmans EE, Alessi MC, Bertone P, Jordan G, Kettleborough RN, Kiddle G, Kostadima M, Read RJ, Sipos B, Sivapalaratnam S, Smethurst PA, Stephens J, Voss K, Nurden A, Rendon A, Nurden P and Ouwehand WH

    Nature genetics 2011;43;8;735-7

  • Genome-wide analysis of simultaneous GATA1/2, RUNX1, FLI1, and SCL binding in megakaryocytes identifies hematopoietic regulators.

    Tijssen MR, Cvejic A, Joshi A, Hannah RL, Ferreira R, Forrai A, Bellissimo DC, Oram SH, Smethurst PA, Wilson NK, Wang X, Ottersbach K, Stemple DL, Green AR, Ouwehand WH and Göttgens B

    Developmental cell 2011;20;5;597-609

* quick link - http://q.sanger.ac.uk/c0vrr8oo