Academic Faculty

Our research is built upon our Faculty of almost 40 research leaders. Each develops his or her own hypothesis-driven research, seeking answers to important biomedical questions. The Faculty member leads a team of postdoctoral fellows, PhD students and support staff.

The research projects of each Faculty member must strengthen our overarching areas of Human Genetics, Mouse and Zebrafish Genetics, Pathogen Genetics, Malaria, and Bioinformatics.

Faculty members often lead national or international collaborative programmes. In addition, most are responsible for one or more of our main resources, such as sequencing programmes or database development.

David Aanensen, faculty member.

David Aanensen - Genomic Epidemiology of Infectious Diseases

David's focus is on the global genomic epidemiology of infectious disease and the use and development of translational bioinformatic applications for public health.
David's email and profile

David Adams, faculty member.

David Adams - Experimental cancer genetics

David uses DNA sequencing of patients and genetic screens in human cells and mice to identify cancer genes and genetic interactions.
David's email, profile and project

Carl Anderson, faculty member.

Carl Anderson - Genomics of inflammation and immunity

Carl applies statistical methodology to the analysis of large-scale genetic data sets in a bid to better understand the causes of several common human diseases.
Carl's email, profile and project

Jeffrey Barrett, faculty member.

Jeffrey Barrett - Medical genomics

Jeffrey develops and applies statistical and computational methods for elucidating the genetic factors in complex human diseases, especially those involving autoimmunity.
Jeffrey's email, profile and project

Inês Barroso, faculty member.

Inês Barroso - Metabolic disease group

Inês is Head of Human Genetics and represents Human Genetics on the Board of Management. Inês established the Sanger Institute's Metabolic Disease Group, which uses genetic and genomic approaches to understand the aetiology of common and rare forms of metabolic disease.
Inês' email, profile and project

Matt Berriman, faculty member.

Matt Berriman - Parasite genomics

Matt leads a programme in the genomics of neglected tropical disease parasites, including helminths such as schistosomes, tapeworms, roundworms, hookworms, threadworms and whipworms. He also works closely with the Malaria programme.
Matt's email, profile and project

Oliver Billker, faculty member.

Oliver Billker - Rodent models of malaria

Oliver uses experimental genetics in rodent models to study the basic biology of malaria parasites and their interactions with host and mosquito vectors.
Oliver's email, profile and project

Allan Bradley, faculty member.

Allan Bradley - Mouse genomics

Allan Bradley leads the Sanger Institute's Mouse Genomics Team, which uses the mouse as a model system to investigate the function of individual genes. He is former Director of the Institute, where he holds the title of Director Emeritus.
Allan's email, profile and project

Peter Campbell, faculty member.

Peter Campbell - Cancer genome project

Dr Peter Campbell is Head of the Sanger Institute's Cancer Genome Project. His research focuses on the use of next-generation sequencing technologies for annotating cancer genomes.
Peter's email, profile and project

Gordon Dougan, faculty member.

Gordon Dougan - Microbial pathogenesis

Gordon leads the Microbial pathogenesis group, which investigates the relationship between pathogens and hosts.
Gordon's email, profile and project

Richard Durbin, faculty member.

Richard Durbin - Genome informatics

Richard is Acting Head of Computational Genomics at the Wellcome Trust Sanger Institute. Richard has worked on many areas of biological sequence analysis, and currently focuses on studying human genetic variation by genome-wide resequencing using new sequencing technologies.
Richard's email, profile and project

Daniel Gaffney, faculty member.

Daniel Gaffney - Population and evolutionary genomics of gene regulation

Daniel's group combines computational and statistical methods with high-throughput experimental techniques to understand the role played by changes in gene regulation in disease susceptibility and human evolution.
Daniel's email, profile and project

Mathew Garnett, faculty member.

Mathew Garnett - Translation cancer genomics

Mathew investigates how genetic alterations in cancer contribute to disease and impact on response to therapy.
Mathew's email and profile and project

Martin Hemberg, faculty member.

Martin Hemberg - Stochastic and biophysical models of gene expression

Martin develops computer models of gene regulation, with a focus on gene activity levels in single cells and the genomic regions involved.
Martin's email and profile.

Matthew Hurles, faculty member.

Matthew Hurles - Genomic mutation and genetic disease

Matt's group aims to elucidate the genetic architecture of developmental disorders, and characterise mutation processes in mammalian genomes.
Matthew's email, profile and project

Philip Jones, faculty member.

Philip Jones - Pre-cancer

Phil studies clonal evolution in epithelial cancer development, focusing on how mutation of single stem cells alters their dynamics to give them a competitive advantage.
Philip's email, profile and project

Paul Kellam, faculty member.

Paul Kellam - Virus genomics

Paul's laboratory investigates virus genetic variation and virus-host cell interactions. He is a Professor of Viral Pathogenesis at University College London.
Paul's email, profile and project

Dominic Kwiatkowski, faculty member.

Dominic Kwiatkowski - Natural genetic variation

Dominic is Head of the Malaria Programme at the Sanger Institute, which uses genomic and genetic approaches to study natural genetic variation in Plasmodium parasites and Anopheles vectors, as well as human genetic determinants of severe malaria.
Dominic's email, profile and project

Trevor Lawley, faculty member.

Trevor Lawley - Host-microbiota interactions

Trevor studies the mechanisms that underlie how micro-organisms in the gut interact with their host during periods of health and disease. In particular he seeks to develop novel ways to treat diseases that are associated with unwanted imbalances in the micro-organism population.
Trevor's email, profile and project

Mara Lawniczak, faculty member.

Mara Lawniczak - Vector-parasite interactions

Mara studies how genetic variation in mosquitoes influences the development of the human malaria parasites they carry
Mara's email, profile and project

Pentao Liu, faculty member.

Pentao Liu - Mouse cancer genetics

Pentao's laboratory studies cancer and mouse development. He uses a range of genetic, genomic and biochemical approaches in the lab and develops novel technologies to facilitate the lab's studies.
Pentao's email, profile and project

Darren Logan, faculty member.

Darren Logan - Genetics of behaviour

Darren's team aims to understand the genes that enable animals to detect and respond to social signals with an appropriate behaviour
Darren's email, profile and project

Ultan McDermott, faculty member.

Ultan McDermott - Cancer genome project

Ultan's goal is to integrate genomic and drug sensitivity datasets from human cancer cell line models in order to identify biomarkers to use in clinical trials.
Ultan's email, profile and project pages.

Ville Mustonen, faculty member.

Ville Mustonen - Population genomics of adaptation

Ville develops computational methods to discover and understand functionally relevant genetic and phenotypic variation.
Ville's email, profile and project pages.

Serena Nik-Zainal, faculty member.

Serena Nik-Zainal - Signatures of mutagenesis in somatic cells

Serena explores patterns of mutations (or signatures) that arise in human cells to understand how DNA damage and DNA repair processes contribute towards aging and cancer.
Serena's email, profile and project pages.

Julian Parkhill, faculty member.

Julian Parkhill - Pathogen genomics

Julian is the Board of Management representative for the Pathogen Variation Programme at the Sanger Institute. He uses high-throughput sequencing and phenotyping to study pathogen diversity and variation, how they affect virulence and transmission, and what they tell us about the evolution of pathogenicity and host interactions.
Julian's email, profile and project

Leo Parts, faculty member.

Leopold Parts - Genetic screens of cellular traits

Leo studies how to best measure, model, and modulate cellular traits by combining high-throughput single-cell measurements with genetic screens.
Leo's email and profile.

Julian Rayner, faculty member.

Julian Rayner - Erythrocyte-parasite interactions

Julian's lab investigates the molecular details of human-parasite interactions during the P. falciparum blood stages, with a particular focus on genomic and proteomic approaches to understanding erythrocyte invasion and how that process is influenced by natural genetic variation in both host and parasite.
Julian's email, profile and project

Manj Sandhu, faculty member.

Manj Sandhu - Genetic epidemiology

Manj's research explores genomic diversity and its impact on infectious and cardiometabolic risk factors among populations.
Manj's email, profile and project

Bill Skarnes, faculty member.

Bill Skarnes - Stem cell engineering

Bill is exploiting new genome-editing technology for the study of gene function and disease modelling in human stem cells.
Bill's email, profile and project

Nicole Soranzo, faculty member.

Nicole Soranzo - Genomics of quantitative variation

Nicole's team works to expand discovery of novel genetic loci for intermediate cardiovascular endpoints through associations of common and rare DNA variation with biochemical and physiologic intermediate phenotypes.
Nicole's email, profile and project

Derek Stemple, faculty member.

Derek Stemple - Vertebrate development and genetics

Derek is Head of Mouse and Zebrafish Genetics. Derek's team works on a range of projects related to growth and development and human disease, using the model organisms X. tropicalis and the zebrafish.
Derek's email, profile and project

Michael Stratton, faculty member.

Michael Stratton - Cancer genome project

Mike Stratton is Director of the Wellcome Trust Sanger Institute, where he initiated the Cancer Genome Project, which conducts systematic genome-wide searches for somatic mutations in human cancer.
Michael's email, profile and project

Sarah Teichmann, faculty member.

Sarah Teichmann - Gene expression genomics

Sarah's group uses genomic approaches to study global regulation of gene expression in the mouse immune system.
Sarah's email, profile and project

Nick Thomson, faculty member.

Nick Thomson - Bacterial genomics and evolution

Nick investigates bacterial evolution and spread with a focus on sexually transmitted and diarrhoeal diseases. He is also Professor of Bacterial Genomics and Evolution at the London School of Hygiene and Tropical Medicine.
Nick's email, profile and project

Gosia Trynka, faculty member.

Gosia Trynka - Immune genomics

Gosia's team studies how genetic variants influence many aspects of the immune system and predispose to autoimmune diseases.
Gosia's email and profile

Chris Tyler-Smith, faculty member.

Chris Tyler-Smith - Human evolution

Chris investigates the genetic variation in human populations and the insights this provides into human evolution.
Chris' email, profile and project

Ludovic Vallier, faculty member.

Ludovic Vallier - Pancreatic genetics

Ludovic's group identifies RNA signalling and regulation networks and the genetic variants that control pancreas development to explore their involvement in metabolic disorders.
Ludovic's email and profile and project

George Vassiliou, faculty member.

George Vassiliou - Haematological cancer genetics

George's research seeks to understand the genetic pathways involved in the pathogenesis of haematological cancers and help develop targeted anti-leukaemic therapies.
George's email and profile and project

Thierry Voet

Thierry Voet - Single-cell genomics

Thierry's group focuses on developing methods that characterise the DNA and RNA in a single cell to enable the exploration of DNA-mutation, the genetic differences between cells in a person's body and the relation of this diversity to disease.
Thierry's email, profile and project

Gavin Wright, faculty member.

Gavin Wright - Cell surface signalling laboratory

Gavin's research focuses on taking large-scale systematic approaches to identify novel receptor-ligand pairs that initiate intercellular signalling.
Gavin's email, profile and project

Kosuke Yusa, faculty member.

Kosuke Yusa - Stem cell genetics

Kosuke's research develops novel genetic engineering technologies in embryonic and induced pluripotent stem cells for genetic screening and healthcare therapies.
Kosuke's email, profile and project

Eleftheria Zeggini, faculty member.

Eleftheria Zeggini - Analytical genomics of complex traits

Ele's work aims to help elucidate the genetic determinants of complex human traits by using next-generation association studies to identify novel disease loci.
Ele's email, profile and project

Associate Faculty

Associate Faculty members spend part of their time at the Institute, bringing complementary insights and expertise of new areas of research to the knowledge and resources of the Sanger Institute and thus broaden our portfolio of scientific inquiry.

Adrian Bird - Associate Faculty.

Adrian Bird - Epigenetic mechanisms in health and disease

Adrian's group studies the way chemical marking of chromosomes affects the activity of the genome in normal and diseased cells.
Adrian's email, profile and project

Ewan Birney - Associate Faculty.

Ewan Birney - Using outbred genetic variation to understand basic biology

Ewan's group is using genomic data to study changes in skeleton shape and form, the development of heart problems, and basic biological processes in human in whole organisms and individual cells.
Ewan's email, profile and project

John Danesh - Associate Faculty.

John Danesh

John will be working with the Institute to further understand cardiometabolic traits through combining cardiovascular epidemiology with genomic research techniques.
John's email.

Bob Hancock - Associate Faculty.

Bob Hancock - Systems biology of host-pathogen interactions

Bob's research group is involved in the development of novel treatments for antibiotic resistant infections.
Bob's email, profile and project

Steve Jackson - Associate Faculty.

Steve Jackson - Maintenance of genome stability

Steve's group focuses on understanding how cells detect and repair DNA damage.
Steve's email, profile and project

John Marioni - Associate Faculty.

John Marioni - Modeling and understanding cell-to-cell heterogeneity in gene expression

John develops computational and statistical tools to exploit high-throughput genomics data to understand the regulation of gene expression and to model developmental and evolutionary processes.
John's email and profile

Erik Miska, honorary faculty member.

Eric Miska - Molecular Genetics

Eric Miska is the Herchel Smith Professor of Molecular Genetics at the University of Cambridge. Eric has strong and diverse interests in genomic biology, including in small RNA biology, epigenetic chromatin regulation and molecular evolution. He has joined the Computational Genomics Programme and will also be working closely with the Mouse and Zebrafish, Human Genetics and Cellular Genetics Programmes.
Eric's profile.

Duncan Odom - Associate Faculty.

Duncan Odom - Regulatory evolution in mammalian tissues

Duncan Odom's research group compares how transcription and transcriptional regulation vary during evolution, and the implications this regulatory plasticity has for diseases such as cancer.
Duncan's home institute email, Sanger Institute email, profile and project

Chris Ponting - Associate Faculty.

Chris Ponting - Computational genome biology

Chris' group analyses next-generation sequencing data to better understand basic biological and disease processes.
Chris' email, profile and project

Fiona Powrie - Associate Faculty.

Fiona Powrie

Fiona will work with the Institute towards further understanding of intestinal microbiota host interactions and of how these influence infectious and chronic inflammatory diseases.
Fiona's email

Stephen O'Rahilly - Associate Faculty.

Stephen O'Rahilly

Stephen will be working with the Institute towards further understanding the molecular mechanisms in metabolic disease.
Stephen's email

Wolf Reik - Associate Faculty.

Wolf Reik - Epigenetic reprogramming

Wolf's team investigates the way additional information can be added to DNA sequence in the genome through a process called epigenetics.
Wolf's email, profile and project

Toni Vidal-Puig - Associate Faculty.

Toni Vidal-Puig

Toni will be working with the Institute using mouse models to understand genes that affect energy balance and mechanisms responsible for the secondary complications of obesity.
Toni's email

International Fellow

Abdoulaye Djimdé - International Fellow.

Dr Abdoulaye Djimdé

Abdoulaye Djimdé is a leading malaria researcher based in Mali, working primarily on the genetic epidemiology of antimalarial drug resistance in West Africa.
Abdoulaye's email and profile

Samuel Kariuki - International Fellow.

Dr Samuel Kariuki

Sam utilises molecular tools to investigate the field epidemiology of key enteric infections and antimicrobial resistance transmission and ecology in the community in Kenya and the region.
Samuel's email and profile

Honorary Faculty

Honorary FacultyThe Sanger Institute has an Honorary Faculty of researchers from other research centres. Our Honorary Faculty collaborate closely with teams at the Sanger Institute to answer a range of research questions.


Previous Faculty

Previous FacultyPrevious members of our Faculty have developed their research in other centres around the globe. Access information and email addresses for previous Faculty.


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