Catalogue of Somatic Mutations in Cancer

Sample Source
Cultured Sample
Tumour Sample

Systematic Screen
From Systematic Screen

Distribution of somatic mutations in RET

Gene: AA to
Sequence Type: cDNA Amino Acid

There are 4 additional mutations not displayed in the above image, as they are without positional information.


Mutation Type	Number	Percentage	Mutation Data
Deletion Frameshift	0	0.0 %	More Details
Deletion Inframe	11	3.1 %	More Details
Insertion Frameshift	0	0.0 %	More Details
Insertion Inframe	0	0.0 %	More Details
Substitution Nonsense	0	0.0 %	More Details
Substitution Missense	308	88.0 %	More Details
Substitution Synonymous	6	1.7 %	More Details
Complex	21	6.0 %	More Details
Other	4	1.1 %	More Details
Total	350	100%	More Details


Sample Source	Number	Percentage	Source Data
Cultured Sample	7	2.0 %	More Details
Tumour Sample	325	93.1 %	More Details
NS	17	4.9 %	More Details
Total	349	100%	More Details

Substitutions
Position	Mutation(n)
145	p.V145G(1)
163	p.R163Q(1)
348	p.R348R(1)
360	p.R360W(1)
373	p.A373A(1)
591	p.V591I(1)
593	p.G593E(1)
609	p.C609Y(1)
618	p.C618R(1) p.C618Y(1)
620	p.C620R(1) p.C620S(1)
630	p.C630G(1) p.C630R(3) p.C630R(1)
631	p.D631G(1)
634	p.C634A(1) p.C634C(1) p.C634R(8) p.C634R(5) p.C634T(1) p.C634W(4) p.C634W(3) p.C634Y(4) p.C634Y(1)
664	p.A664D(2)
748	p.G748C(1)
766	p.P766S(1)
768	p.E768D(4)
778	p.V778V(1)
792	p.G792G(1)
876	p.A876V(1)
883	p.A883F(4) p.A883F(1) p.A883F(1) p.A883P(1) p.A883S(1)
884	p.E884K(1)
901	p.E901K(1)
908	p.R908K(1)
911	p.G911D(1)
918	p.M918T(232) p.M918T(13)
919	p.A919V(1)
921	p.E921K(1)
922	p.S922P(1)
925	p.D925H(1)
930	p.T930M(1)
974	p.D974D(1)
1112	p.F1112Y(1)

Insertions
Position	Mutation(n)
No Insertions in Current Selection

Deletions
Position	Mutation(n)
592	p.G592_G607del(1)
612	p.F612_C620del(1)
632	p.E632_L633del(6) p.E632_L633del(1)
898	p.D898_E901del(1) p.D898_E901del(1)

Complex
Position	Mutation(n)
627	p.D627_L633>E(1)
629	p.L629_D631>H(2)
631	p.D631_L633>E(1)
632	p.E632_A640>VRP(1) p.E632_C634>L(1) p.E632_L633>V(1) p.E632_T636>SS(14)

Fusion Mutations
Mutation(n)
No Fusion Mutations in Current Selection

Other Mutations
Position	Mutation(n)
	p.?(3) p.?(1)

Details for RET
Primary Tissue	Unique Mutated Samples	% Mutated	Total Unique Samples	Mutation Data
NS	0	0%	2	More Details
adrenal gland	19	6%	324	More Details
autonomic ganglia	0	0%	183	More Details
biliary tract	0	0%	6	More Details
bone	0	0%	32	More Details
breast	0	0%	100	More Details
central nervous system	1	1%	177	More Details
cervix	0	0%	13	More Details
endometrium	0	0%	10	More Details
eye	0	0%	1	More Details
gastrointestinal tract (site indeterminate)	0	0%	11	More Details
haematopoietic and lymphoid tissue	0	0%	154	More Details
kidney	0	0%	45	More Details
large intestine	5	4%	142	More Details
liver	0	0%	10	More Details
lung	3	1%	232	More Details
oesophagus	0	0%	23	More Details
ovary	1	2%	47	More Details
pancreas	0	0%	57	More Details
parathyroid	0	0%	182	More Details
pituitary	0	0%	180	More Details
placenta	0	0%	2	More Details
pleura	0	0%	6	More Details
prostate	0	0%	5	More Details
salivary gland	0	0%	10	More Details
skin	0	0%	57	More Details
small intestine	0	0%	1	More Details
soft tissue	0	0%	23	More Details
stomach	0	0%	41	More Details
testis	0	0%	17	More Details
thyroid	319	34%	944	More Details
upper aerodigestive tract	0	0%	39	More Details
urinary tract	1	6%	18	More Details
vulva	0	0%	3	More Details
Totals	349	11%	3097	More Details

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Last Modified Mon Sep 18 17:13:20 2006

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