Single-cell RNA-seq identifies a PD-1(hi) ILC progenitor and defines its development pathway.
The transcription factor Bcl11b is specifically expressed in group 2 innate lymphoid cells and is essential for their development.
The Journal of experimental medicine 2015;212;6;865-74
Single-cell transcriptomic reconstruction reveals cell cycle and multi-lineage differentiation defects in Bcl11a-deficient hematopoietic stem cells.
Genome biology 2015;16;178
Bcl11a is essential for lymphoid development and negatively regulates p53.
The Journal of experimental medicine 2012;209;13;2467-83