Dr James Christopher Wright | Principal Bioinformatician

Wright, James Christopher

I have moved to the Institute of Cancer Research in London (October 2017)

My work is focussed on proteomic bioinformatics, developing new tools, pipelines and methods for quantitative proteomics data analysis, proteogenomic studies, and post translational modification discovery. This has included the continued development of MascotPercolator as a tool for improving spectral identification scoring in proteomics experiments, software to align, quantify and normalise HDMSe dataset for proteomic profiling of tissues, and tools to detect and validate unexpected modifications in proteomics datasets. I am also heavily involved in the development of workflows for proteogenomic data analysis for genome annotation.

Publications

  • Genomic Determinants of Protein Abundance Variation in Colorectal Cancer Cells.

    Roumeliotis TI, Williams SP, Gonçalves E, Alsinet C, Del Castillo Velasco-Herrera M et al.

    Cell reports 2017;20;9;2201-2214

  • Flexible Data Analysis Pipeline for High-Confidence Proteogenomics.

    Weisser H, Wright JC, Mudge JM, Gutenbrunner P and Choudhary JS

    Journal of proteome research 2016;15;12;4686-4695

  • DecoyPyrat: Fast Non-redundant Hybrid Decoy Sequence Generation for Large Scale Proteomics.

    Wright JC and Choudhary JS

    Journal of proteomics & bioinformatics 2016;9;6;176-180

  • Improving GENCODE reference gene annotation using a high-stringency proteogenomics workflow.

    Wright JC, Mudge J, Weisser H, Barzine MP, Gonzalez JM et al.

    Nature communications 2016;7;11778

  • Interferon-driven alterations of the host's amino acid metabolism in the pathogenesis of typhoid fever.

    Blohmke CJ, Darton TC, Jones C, Suarez NM, Waddington CS et al.

    The Journal of experimental medicine 2016;213;6;1061-77

  • Expression Atlas update--an integrated database of gene and protein expression in humans, animals and plants.

    Petryszak R, Keays M, Tang YA, Fonseca NA, Barrera E et al.

    Nucleic acids research 2016;44;D1;D746-52

  • Confident and sensitive phosphoproteomics using combinations of collision induced dissociation and electron transfer dissociation.

    Collins MO, Wright JC, Jones M, Rayner JC and Choudhary JS

    Journal of proteomics 2014;103;1-14

  • The OMSSAPercolator: an automated tool to validate OMSSA results.

    Wen B, Li G, Wright JC, Du C, Feng Q et al.

    Proteomics 2014;14;9;1011-4

  • The PRoteomics IDEntification (PRIDE) Converter 2 framework: an improved suite of tools to facilitate data submission to the PRIDE database and the ProteomeXchange consortium.

    Côté RG, Griss J, Dianes JA, Wang R, Wright JC et al.

    Molecular & cellular proteomics : MCP 2012;11;12;1682-9

  • Enhanced peptide identification by electron transfer dissociation using an improved Mascot Percolator.

    Wright JC, Collins MO, Yu L, Käll L, Brosch M and Choudhary JS

    Molecular & cellular proteomics : MCP 2012;11;8;478-91

  • Shotgun proteomics aids discovery of novel protein-coding genes, alternative splicing, and "resurrected" pseudogenes in the mouse genome.

    Brosch M, Saunders GI, Frankish A, Collins MO, Yu L et al.

    Genome research 2011;21;5;756-67

  • Cross species proteomics.

    Wright JC, Beynon RJ and Hubbard SJ

    Methods in molecular biology (Clifton, N.J.) 2010;604;123-35

  • Recent developments in proteome informatics for mass spectrometry analysis.

    Wright JC and Hubbard SJ

    Combinatorial chemistry & high throughput screening 2009;12;2;194-202

  • Exploiting proteomic data for genome annotation and gene model validation in Aspergillus niger.

    Wright JC, Sugden D, Francis-McIntyre S, Riba-Garcia I, Gaskell SJ et al.

    BMC genomics 2009;10;61

Career/Research Highlights

Wright, James Christopher
James's Timeline
2017

Left Sanger and moved to ICR London

2009

Joined Proteomic Mass Spectrometry Team at Wellcome Trust Sanger Institute

2005

PhD Cross Species Proteomics - University of Liverpool and University of Manchester

2004

MSc Physical Methods for Bioanalysis and Post Genomic Science - University of Manchester

2002

EST Informatics - AstraZeneca

2000

BSc Biological and Computational Science - UMIST