Alex manages a number of transposon-based insertional mutagenesis screens in mice. Using mouse lines developed within the Bradley lab he conducts constitutive, tissue-specific, dominant and recessive genetic screens. He also works to validate and further study the genes highlighted by these screens.
CRISPR/Cas9 somatic multiplex-mutagenesis for high-throughput functional cancer genomics in mice.
Proceedings of the National Academy of Sciences of the United States of America 2015;112;45;13982-7
A Synergistic Interaction between Chk1- and MK2 Inhibitors in KRAS-Mutant Cancer.
A conditional piggyBac transposition system for genetic screening in mice identifies oncogenic networks in pancreatic cancer.
Nature genetics 2015;47;1;47-56
A genetic progression model of Braf(V600E)-induced intestinal tumorigenesis reveals targets for therapeutic intervention.
Cancer cell 2013;24;1;15-29
PiggyBac transposon mutagenesis: a tool for cancer gene discovery in mice.
Science (New York, N.Y.) 2010;330;6007;1104-7