Sumana Sharma | PhD Student

Sharma, Sumana

Sumana is a PhD student working on developing methods to identify and validate protein interactions between Plasmodium merozoites and human host cells, which are required for the pathogenenis of malaria.

I am interested in understanding the molecular mechanisms behind the invasion of human host erythrocytes by Plasmodium parasites. This process involves many host-parasite protein-protein interactions but very few of these are known to date. Currently, I am developing a CRISPR/Cas9 based cellular screen to identify novel low affinity receptor ligand interactions using highly avid recombinant proteins and the resources developed by Kosuke Yusa for genome-wide recessive screens.

Publications

  • A Library of Plasmodium vivax Recombinant Merozoite Proteins Reveals New Vaccine Candidates and Protein-Protein Interactions.

    Hostetler JB, Sharma S, Bartholdson SJ, Wright GJ, Fairhurst RM and Rayner JC

    PLoS neglected tropical diseases 2015;9;12;e0004264

  • An Antibody Screen of a Plasmodium vivax Antigen Library Identifies Novel Merozoite Proteins Associated with Clinical Protection.

    França CT, Hostetler JB, Sharma S, White MT, Lin E et al.

    PLoS neglected tropical diseases 2016;10;5;e0004639

Sharma, Sumana
Sumana's Timeline
2013

Joined the Wellcome Trust PhD program

Completed M.Sc degree in Molecular Biology from International Max Planck Research School, Goettingen University, Germany

2012

Started an external M.Sc thesis project with Dr. Julian Rayner on identification and characterization of protein interaction in Plasmodium falciparum.

2011

Completed B.Sc degree in Biochemistry and Cell Biology from Jacobs Univeristy Bremen, Germany