Sumana is a PhD student working on developing methods to identify and validate protein interactions between Plasmodium merozoites and human host cells, which are required for the pathogenenis of malaria.
I am interested in understanding the molecular mechanisms behind the invasion of human host erythrocytes by Plasmodium parasites. This process involves many host-parasite protein-protein interactions but very few of these are known to date. Currently, I am developing a CRISPR/Cas9 based cellular screen to identify novel low affinity receptor ligand interactions using highly avid recombinant proteins and the resources developed by Kosuke Yusa for genome-wide recessive screens.
A Library of Plasmodium vivax Recombinant Merozoite Proteins Reveals New Vaccine Candidates and Protein-Protein Interactions.
PLoS neglected tropical diseases 2015;9;12;e0004264
An Antibody Screen of a Plasmodium vivax Antigen Library Identifies Novel Merozoite Proteins Associated with Clinical Protection.
PLoS neglected tropical diseases 2016;10;5;e0004639