Dr Julia Knoeckel | Postdoctoral Fellow

Knoeckel, Julia

Julia is a postdoctoral fellow in the Malaria Programme. In her project she investigates which proteins are important for malaria parasites to invade the mosquito salivary gland. This step is essential for parasite transmission to humans and understanding the underlying mechanisms can help to identify new drug- and vaccine targets.

I joined the labs of Gavin Wright and Julian Rayner in the Sanger Institute Malaria Programme in 2013. In my project I am working with mosquito stages of the malaria parasite Plasmodium falciparum. Plasmodium ookinetes and sporozoites have to travel from the midgut of the mosquito into the salivary gland to be transmitted to a human host. However, our knowledge on how the parasite reaches and invades the salivary gland is quite limited. The aim of my project is to identify novel and essential interactions between parasite and mosquito proteins, which could provide new targets to block transmission of malaria.

Publications

  • Could culicine mosquitoes transmit human malaria?

    Molina-Cruz A, Lehmann T and Knöckel J

    Trends in parasitology 2013;29;11;530-7

  • An impossible journey? The development of Plasmodium falciparum NF54 in Culex quinquefasciatus.

    Knöckel J, Molina-Cruz A, Fischer E, Muratova O, Haile A et al.

    PloS one 2013;8;5;e63387

  • The antioxidative effect of de novo generated vitamin B6 in Plasmodium falciparum validated by protein interference.

    Knöckel J, Müller IB, Butzloff S, Bergmann B, Walter RD and Wrenger C

    The Biochemical journal 2012;443;2;397-405

  • Mobility of the conserved glycine 155 is required for formation of the active plasmodial Pdx1 dodecamer.

    Knöckel J, Jordanova R, Müller IB, Wrenger C and Groves MR

    Biochimica et biophysica acta 2009;1790;5;347-50

  • The assembly of the plasmodial PLP synthase complex follows a defined course.

    Müller IB, Knöckel J, Groves MR, Jordanova R, Ealick SE et al.

    PloS one 2008;3;3;e1815

  • The apicomplexan parasite Toxoplasma gondii generates pyridoxal phosphate de novo.

    Knöckel J, Müller IB, Bergmann B, Walter RD and Wrenger C

    Molecular and biochemical parasitology 2007;152;1;108-11

  • Could culicine mosquitoes transmit human malaria?

    Molina-Cruz A, Lehmann T and Knöckel J

    Trends in parasitology 2013;29;11;530-7

  • An impossible journey? The development of Plasmodium falciparum NF54 in Culex quinquefasciatus.

    Knöckel J, Molina-Cruz A, Fischer E, Muratova O, Haile A et al.

    PloS one 2013;8;5;e63387

  • The antioxidative effect of de novo generated vitamin B6 in Plasmodium falciparum validated by protein interference.

    Knöckel J, Müller IB, Butzloff S, Bergmann B, Walter RD and Wrenger C

    The Biochemical journal 2012;443;2;397-405

  • Secretion of an acid phosphatase provides a possible mechanism to acquire host nutrients by Plasmodium falciparum.

    Müller IB, Knöckel J, Eschbach ML, Bergmann B, Walter RD and Wrenger C

    Cellular microbiology 2010;12;5;677-91

  • Mobility of the conserved glycine 155 is required for formation of the active plasmodial Pdx1 dodecamer.

    Knöckel J, Jordanova R, Müller IB, Wrenger C and Groves MR

    Biochimica et biophysica acta 2009;1790;5;347-50

  • The assembly of the plasmodial PLP synthase complex follows a defined course.

    Müller IB, Knöckel J, Groves MR, Jordanova R, Ealick SE et al.

    PloS one 2008;3;3;e1815

  • Filling the gap of intracellular dephosphorylation in the Plasmodium falciparum vitamin B1 biosynthesis.

    Knöckel J, Bergmann B, Müller IB, Rathaur S, Walter RD and Wrenger C

    Molecular and biochemical parasitology 2008;157;2;241-3

  • Vitamin B1 and B6 in the malaria parasite: requisite or dispensable?

    Wrenger C, Knöckel J, Walter RD and Müller IB

    Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.] 2008;41;2;82-8

  • The apicomplexan parasite Toxoplasma gondii generates pyridoxal phosphate de novo.

    Knöckel J, Müller IB, Bergmann B, Walter RD and Wrenger C

    Molecular and biochemical parasitology 2007;152;1;108-11

Knoeckel, Julia
Julia's Timeline
2013

Postdoctoral Fellow at Wellcome Trust Sanger Institute

2009

Postdoctoral Fellow at National Institutes of Health (NIH), Rockville, MD, USA

Visiting Scientist at Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany

PhD in Zoology, University of Hamburg, Germany

2006

PhD student at Bernhard Nocht Institute for tropical Medicine, Hamburg, Germany

MSc in Biology, University of Bielefeld, Germany