Phil H Jones | Senior Group Leader

Phil studies the earliest steps in cancer development, how specific alterations in the DNA of normal stem cells changes their behaviour to promote tumour formation.

My research focuses on how tumours evolve from individual mutant stem cells in the skin epidermis and oesophagus. 

Our current work  uses genetic lineage tracing, deep sequencing, live imaging and single cell analysis to define how oncogenic mutations alter the behaviour of stem cells during squamous carcinogenesis.  

These lab based studies complement my clinical work at Addenbrooke's Hospital treating patients with non-melanoma skin cancer.  We aim to apply our research to develop rational interventions to reduce cancer risk in carcinogen exposed patients.

 

Publications

  • Human keratinocytes have two interconvertible modes of proliferation.

    Roshan A, Murai K, Fowler J, Simons BD, Nikolaidou-Neokosmidou V and Jones PH

    Nature cell biology 2016;18;2;145-56

  • Tumor evolution. High burden and pervasive positive selection of somatic mutations in normal human skin.

    Martincorena I, Roshan A, Gerstung M, Ellis P, Van Loo P et al.

    Science (New York, N.Y.) 2015;348;6237;880-6

  • Differentiation imbalance in single oesophageal progenitor cells causes clonal immortalization and field change.

    Alcolea MP, Greulich P, Wabik A, Frede J, Simons BD and Jones PH

    Nature cell biology 2014;16;6;615-22

  • A single progenitor population switches behavior to maintain and repair esophageal epithelium.

    Doupé DP, Alcolea MP, Roshan A, Zhang G, Klein AM et al.

    Science (New York, N.Y.) 2012;337;6098;1091-3

  • The ordered architecture of murine ear epidermis is maintained by progenitor cells with random fate.

    Doupé DP, Klein AM, Simons BD and Jones PH

    Developmental cell 2010;18;2;317-23

  • Stochastic fate of p53-mutant epidermal progenitor cells is tilted toward proliferation by UV B during preneoplasia.

    Klein AM, Brash DE, Jones PH and Simons BD

    Proceedings of the National Academy of Sciences of the United States of America 2010;107;1;270-5

  • A single type of progenitor cell maintains normal epidermis.

    Clayton E, Doupé DP, Klein AM, Winton DJ, Simons BD and Jones PH

    Nature 2007;446;7132;185-9

  • Notch signaling regulates the differentiation of post-mitotic intestinal epithelial cells.

    Zecchini V, Domaschenz R, Winton D and Jones P

    Genes & development 2005;19;14;1686-91

  • Hes6 regulates myogenic differentiation.

    Cossins J, Vernon AE, Zhang Y, Philpott A and Jones PH

    Development (Cambridge, England) 2002;129;9;2195-207

  • Stem cell patterning and fate in human epidermis.

    Jones PH, Harper S and Watt FM

    Cell 1995;80;1;83-93

  • Separation of human epidermal stem cells from transit amplifying cells on the basis of differences in integrin function and expression.

    Jones PH and Watt FM

    Cell 1993;73;4;713-24

  • Constrained positive selection on cancer mutations in normal skin.

    Martincorena I, Jones PH and Campbell PJ

    Proceedings of the National Academy of Sciences of the United States of America 2016;113;9;E1128-9

  • Human keratinocytes have two interconvertible modes of proliferation.

    Roshan A, Murai K, Fowler J, Simons BD, Nikolaidou-Neokosmidou V and Jones PH

    Nature cell biology 2016;18;2;145-56

  • Tumor evolution. High burden and pervasive positive selection of somatic mutations in normal human skin.

    Martincorena I, Roshan A, Gerstung M, Ellis P, Van Loo P et al.

    Science (New York, N.Y.) 2015;348;6237;880-6

  • Switching roles: the functional plasticity of adult tissue stem cells.

    Wabik A and Jones PH

    The EMBO journal 2015;34;9;1164-79

  • The human squamous oesophagus has widespread capacity for clonal expansion from cells at diverse stages of differentiation.

    Barbera M, di Pietro M, Walker E, Brierley C, MacRae S et al.

    Gut 2015;64;1;11-9

  • Cell competition: winning out by losing notch.

    Alcolea MP and Jones PH

    Cell cycle (Georgetown, Tex.) 2015;14;1;9-17

  • Mutation, clonal fitness and field change in epithelial carcinogenesis.

    Frede J, Adams DJ and Jones PH

    The Journal of pathology 2014;234;3;296-301

  • Exact, time-independent estimation of clone size distributions in normal and mutated cells.

    Roshan A, Jones PH and Greenman CD

    Journal of the Royal Society, Interface / the Royal Society 2014;11;99

  • Esophageal stem cells and genetics/epigenetics in esophageal cancer.

    Croagh D, Frede J, Jones PH, Kaur P, Partensky C and Phillips WA

    Annals of the New York Academy of Sciences 2014;1325;8-14

  • Differentiation imbalance in single oesophageal progenitor cells causes clonal immortalization and field change.

    Alcolea MP, Greulich P, Wabik A, Frede J, Simons BD and Jones PH

    Nature cell biology 2014;16;6;615-22

  • Lineage analysis of epidermal stem cells.

    Alcolea MP and Jones PH

    Cold Spring Harbor perspectives in medicine 2014;4;1;a015206

  • Development. Permission to proliferate.

    Frede J and Jones PH

    Science (New York, N.Y.) 2013;342;6163;1183-4

  • Tracking cells in their native habitat: lineage tracing in epithelial neoplasia.

    Alcolea MP and Jones PH

    Nature reviews. Cancer 2013;13;3;161-71

  • HES6 enhances the motility of alveolar rhabdomyosarcoma cells.

    Wickramasinghe CM, Domaschenz R, Amagase Y, Williamson D, Missiaglia E et al.

    Experimental cell research 2013;319;1;103-12

  • Act your age: tuning cell behavior to tissue requirements in interfollicular epidermis.

    Roshan A and Jones PH

    Seminars in cell & developmental biology 2012;23;8;884-9

  • Chronic low dose UV exposure and p53 mutation: tilting the odds in early epidermal preneoplasia?

    Roshan A and Jones PH

    International journal of radiation biology 2012;88;10;682-7

  • A single progenitor population switches behavior to maintain and repair esophageal epithelium.

    Doupé DP, Alcolea MP, Roshan A, Zhang G, Klein AM et al.

    Science (New York, N.Y.) 2012;337;6098;1091-3

  • Interfollicular epidermal homeostasis: dicing with differentiation.

    Doupé DP and Jones PH

    Experimental dermatology 2012;21;4;249-53

  • Patterning as a signature of human epidermal stem cell regulation.

    Klein AM, Nikolaidou-Neokosmidou V, Doupé DP, Jones PH and Simons BD

    Journal of the Royal Society, Interface / the Royal Society 2011;8;65;1815-24

  • Hes6 is required for actin cytoskeletal organization in differentiating C2C12 myoblasts.

    Malone CM, Domaschenz R, Amagase Y, Dunham I, Murai K and Jones PH

    Experimental cell research 2011;317;11;1590-602

  • Acute sensitivity of the oral mucosa to oncogenic K-ras.

    van der Weyden L, Alcolea MP, Jones PH, Rust AG, Arends MJ and Adams DJ

    The Journal of pathology 2011;224;1;22-32

  • Hes6 is required for the neurogenic activity of neurogenin and NeuroD.

    Murai K, Philpott A and Jones PH

    PloS one 2011;6;11;e27880

  • Intestinal activation of Notch signaling induces rapid onset hepatic steatosis and insulin resistance.

    Fowler JC, Zecchini VR and Jones PH

    PloS one 2011;6;6;e20767

  • Stem cell fate in proliferating tissues: equal odds in a game of chance.

    Jones PH

    Developmental cell 2010;19;4;489-90

  • The ordered architecture of murine ear epidermis is maintained by progenitor cells with random fate.

    Doupé DP, Klein AM, Simons BD and Jones PH

    Developmental cell 2010;18;2;317-23

  • Stochastic fate of p53-mutant epidermal progenitor cells is tilted toward proliferation by UV B during preneoplasia.

    Klein AM, Brash DE, Jones PH and Simons BD

    Proceedings of the National Academy of Sciences of the United States of America 2010;107;1;270-5

  • Mechanism of murine epidermal maintenance: cell division and the voter model.

    Klein AM, Doupé DP, Jones PH and Simons BD

    Physical review. E, Statistical, nonlinear, and soft matter physics 2008;77;3 Pt 1;031907

  • Hypoxia-selective targeting by the bioreductive prodrug AQ4N in patients with solid tumors: results of a phase I study.

    Albertella MR, Loadman PM, Jones PH, Phillips RM, Rampling R et al.

    Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14;4;1096-104

  • High grade glioma: imaging combined with pathological grade defines management and predicts prognosis.

    Burnet NG, Lynch AG, Jefferies SJ, Price SJ, Jones PH et al.

    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2007;85;3;371-8

  • Sic transit gloria: farewell to the epidermal transit amplifying cell?

    Jones PH, Simons BD and Watt FM

    Cell stem cell 2007;1;4;371-81

  • Kinetics of cell division in epidermal maintenance.

    Klein AM, Doupé DP, Jones PH and Simons BD

    Physical review. E, Statistical, nonlinear, and soft matter physics 2007;76;2 Pt 1;021910

  • A single type of progenitor cell maintains normal epidermis.

    Clayton E, Doupé DP, Klein AM, Winton DJ, Simons BD and Jones PH

    Nature 2007;446;7132;185-9

  • Notch signaling regulates the differentiation of post-mitotic intestinal epithelial cells.

    Zecchini V, Domaschenz R, Winton D and Jones P

    Genes & development 2005;19;14;1686-91

  • Phase II trial of the antiangiogenic agent IM862 in metastatic renal cell carcinoma.

    Deplanque G, Madhusudan S, Jones PH, Wellmann S, Christodoulos K et al.

    British journal of cancer 2004;91;9;1645-50

  • Combination antiangiogenesis therapy with marimastat, captopril and fragmin in patients with advanced cancer.

    Jones PH, Christodoulos K, Dobbs N, Thavasu P, Balkwill F et al.

    British journal of cancer 2004;91;1;30-6

  • A phase 1 study of tazarotene in adults with advanced cancer.

    Jones PH, Burnett RD, Fainaru I, Nadolny P, Walker P et al.

    British journal of cancer 2003;89;5;808-15

  • Hes6 regulates myogenic differentiation.

    Cossins J, Vernon AE, Zhang Y, Philpott A and Jones PH

    Development (Cambridge, England) 2002;129;9;2195-207

  • Stromal expression of Jagged 1 promotes colony formation by fetal hematopoietic progenitor cells.

    Jones P, May G, Healy L, Brown J, Hoyne G et al.

    Blood 1998;92;5;1505-11

  • Epithelial stem cells.

    Jones PH

    BioEssays : news and reviews in molecular, cellular and developmental biology 1997;19;8;683-90

  • Functional significance of CD9 association with beta 1 integrins in human epidermal keratinocytes.

    Jones PH, Bishop LA and Watt FM

    Cell adhesion and communication 1996;4;4-5;297-305

  • Isolation and characterization of human epidermal stem cells.

    Jones PH

    Clinical science (London, England : 1979) 1996;91;2;141-6

Career/Research Highlights

Jones, Phil
Follow Phil Online
Phil's Timeline
2015

Publication: Mutations in normal skin

Joined Wellcome Trust Sanger Institute

2014

Fellow of the Academy of Medical Sciences

2012

Publication: Oesophageal stem cells

2011

Programme Leader, MRC Cancer Unit

2007

Publication: Basis of epidermal homeostasis

1995

PhD, London University