My main interest lie in understanding the different aspects behind the development of immune mediated diseases.
Autoimmune diseases are the result of an imbalance in the immune response that leads to the destruction of normal cells and tissues that may leads, in turn, to posterior multi-organ involvement. The understanding of these diseases through the perspective of human genetics has provided enormous insights over the last few years due to the development of new technologies and new methods of analysis and data integration that have helped to discover genetic factors involved in the presentation and development of these diseases.
In the field of genetic analysis of complex traits, the study of immune mediated diseases has seen examples of all these exciting developments through the inclusion of non-Caucasian populations in the analysis, the large number of newly discovered loci, and the new pathways linked to those loci. My work seeks to contribute in a better understanding of the MHC-HLA region, explore both the common and differing factors that add to the complexity of immune mediated diseases, and into examine how non-Caucasian populations can contribute to the comprehension of the development of this group of traits.